Granted Patent B2

US 8,895,047 · App. 12/451,773 · Granted Nov 25, 2014

Abstract

Claims (16)

1. An implantable catheter comprising, in combination, an antimicrobial agent that comprises chlorhexidine incorporated in a coating or bulk distributed combined with urokinase incorporated in a top coating, wherein the chlorhexidine does not decrease the fibrinolytic activity of the urokinase, and wherein the ratio of chlorhexidine/urokinase is 20/1 (weight/weight).

2. The implantable catheter of claim 1 , wherein at least a portion of the catheter is impregnated with the antimicrobial agent.

3. The implantable catheter of claim 1 , wherein at least a portion of the catheter is coated with the antimicrobial agent.

4. The implantable catheter of claim 1 , wherein the antimicrobial agent further comprises gentian violet, minocycline, rifampin, minocycline-rifampin, or a salt thereof.

5. The implantable catheter of claim 4 , wherein the antimicrobial agent further comprises minocycline.

6. The implantable catheter of claim 4 , wherein the antimicrobial agent further comprises rifampin.

7. The implantable catheter of claim 4 , wherein the antimicrobial agent further comprises minocycline-rifampin.

8. The implantable catheter of claim 1 , wherein the antimicrobial agent is present in the catheter in an amount effective to permit absorption of the antimicrobial agent from the catheter.

9. The implantable catheter of claim 1 , wherein the antimicrobial agent is present in a concentration of 0.01%-20% by weight of the catheter.

10. The implantable catheter of claim 1 , wherein the antimicrobial agent has a concentration of about 200 micrograms per cm length of catheter.

11. The implantable catheter of claim 1 , wherein the urokinase is present in the catheter in an amount effective to permit absorption of the urokinase from the catheter.

12. The implantable catheter of claim 1 , wherein the urokinase is present in the catheter from 1 U-1000 U per cm length of catheter or wherein the urokinase is present in the catheter from 10 U-500 U per cm length of catheter.

13. The implantable catheter of claim 1 , wherein the catheter is a transcutaneous catheter, a catheter for implantation in a blood vessel or a body cavity, a venous catheter, an arterial catheter or a dialysis catheter.

14. The implantable catheter of claim 1 , wherein the wherein the antimicrobial agent is present in a concentration of 0.1%-10% by weight of the catheter.

15. The implantable catheter of claim 1 , wherein the urokinase is present in the catheter from 10 U-500 U per cm length of catheter.

16. The implantable catheter of claim 1 , further comprising gentian violet, wherein the ratio of gentian violet/urokinase is 20/1.

Assignments (6)