Laidlomycin compositions and methods
View Patent ↗An animal feed additive composition comprises an effective amount of a laidlomycin, a carrier, magnesium sulfate, and silicon dioxide. Other embodiments include methods of making the animal feed additive compositions, and the use of a laidlomycin in the manufacture of an animal feed additive for increasing the efficiency of feed utilization and rate of weight gain in domestic animals.
1. An animal feed additive composition comprising:
5 wt % to 20 wt % of laidlomycin,
73 wt % to 94 wt % of calcium sulfate,
0.5 wt % to 5.0 wt % of magnesium stearate, and
0.5 wt % to 2.0 wt % of silicon dioxide
wherein all amounts are based on the total weight of the animal feed additive composition and wherein the laidlomycin, calcium sulfate, magnesium stearate and silicon dioxide are formed into a mixture.
2. The animal feed additive composition of claim 1 in the form of a granulate.
3. The animal feed additive composition of claim 1 wherein the laidlomycin is at least 80% laidlomycin A.
4. The animal feed additive composition of claim 3 wherein the composition has a pH of 7.0 to 8.0.
5. The animal feed additive composition of claim 3 wherein the composition has a stability such that after exposure to 60° C. and 75% relative humidity carrier for 8 weeks, less than 20 wt % of the laidlomycin in the composition is degraded.
6. The animal feed additive composition of claim 5 wherein the degradation of laidlomycin is measured by HPLC.
7. An animal feed additive composition comprising:
about 11 wt % laidlomycin,
about 87 wt % calcium sulfate,
about 0.5 wt % magnesium stearate, and
about 0.5 wt % silicon dioxide
wherein all amounts are based on the total weight of the animal feed additive composition and wherein the laidlomycin, calcium sulfate, magnesium stearate and silicon dioxide are formed into a mixture.
8. The animal feed additive composition of claim 7 wherein the laidlomycin is at least 80% laidlomycin A.
9. The animal feed additive composition of claim 7 wherein the composition has a pH of 7.0 to 8.0.
10. The animal feed additive composition of claim 7 wherein the composition has a stability such that after exposure to 60° C. and 75% relative humidity carrier for 8 weeks, less than 20 wt % of the laidlomycin in the composition is degraded.
11. The animal feed additive composition of claim 10 wherein the degradation of laidlomycin is measured by HPLC.
12. An animal feed additive composition comprising:
An animal foodstuff and
11 wt % to 11.5 wt % of laidlomycin,
73 wt % to 94 wt % of calcium sulfate,
0.5 wt % to 5.0 wt % of magnesium stearate, and
0.5 wt % to 2.0 wt % of silicon dioxide
wherein all amounts are based on the total weight of the animal feed additive composition and wherein the laidlomycin, calcium sulfate, magnesium stearate and silicon dioxide are formed into a mixture.
13. The animal feed composition of claim 12 wherein the animal foodstuff is suitable for cattle.
14. The animal feed composition of claim 12 wherein the laidlomycin is at least 80% laidlomycin A.
15. The animal feed composition of claim 12 wherein the composition has a pH of 7.0 to 8.0.
16. A method of making an animal feed additive composition comprising forming a mixture comprising:
5 wt % to 20 wt % of laidlomycin,
73 wt % to 94 wt % of calcium sulfate,
0.5 wt % to 5.0 wt % of magnesium stearate, and
0.5 wt % to 2.0 wt % of silicon dioxide
wherein all amounts are based on the total weight of the animal feed additive; and granulating the mixture to form a granulate.
17. The method of claim 16 wherein the laidlomycin is at least 80% laidlomycin A.
18. The method of claim 16 wherein the composition has a pH of 7.0 to 8.0.
19. The composition of claim 7 wherein the laidlomycin is in the form of laidlomycin propionate potassium.
20. A method of making multiparticulates of an animal feed additive comprising:
(a) forming a solid mixture comprising about 11% laidlomycin, 73 wt % to 94 wt % of calcium sulfate, about 0.5% magnesium stearate, and about 0.5% silicon dioxide; and
(b) granulating the solid mixture to form multiparticulates.
21. The method of claim 20 wherein the granulation step is performed by roller compaction.
22. The animal feed additive composition of claim 1 further comprising an active substance selected from the group consisting of anti-coccidial agents, growth promoting agents, antiparasitic agents, antibiotics or combinations thereof.
23. The animal feed additive composition of claim 1 further comprising one or more growth promoting agents.
24. The animal feed additive composition of claim 1 further comprising one or more antibiotics.
25. The animal feed additive composition of claim 1 further comprising one or more anti-coccidial agents.
26. The animal feed additive composition of claim 1 further comprising one or more antiparasitic agents.