Combine radiation therapy and chemotherapy for treating cancer
A method of treating a tumor of a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of alpha particles and a chemotherapeutic agent, wherein the alpha particles are administered by positioning a non-stable alpha-emitting radionuclide in proximity to and/or within the tumor, so as to administer a dose of alpha particles into the tumor, wherein the method does not comprise administration of an inhibitor of DNA repair, thereby treating the tumor of the subject.
1 . A method of treating a tumor of a subject, the method comprising administering to the subject a therapeutically effective amount of alpha particles and a chemotherapeutic agent, wherein said alpha particles are administered by positioning a non-stable alpha-emitting radionuclide in proximity to and/or within the tumor, so as to administer a dose of alpha particles into the tumor, wherein the method does not comprise administration of an inhibitor of DNA repair, thereby treating the tumor of the subject.
2 . The method of claim 1 , wherein the tumor is a solid tumor.
3 . The method of claim 1 , wherein said non-stable alpha-emitting radionuclide is selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220.
4 . The method of claim 1 , wherein said positioning of said non-stable alpha-emitting radionuclide is effected by at least one radiotherapy device having a surface whereby said alpha-emitting radionuclide is on or beneath said surface.
5 . The method of claim 4 , wherein said at least one radiotherapy device comprises a wire.
6 . The method of claim 1 , wherein said non-stable alpha-emitting radionuclide is comprised in a solution.
7 . The method of claim 1 , wherein said positioning is effected at the base of the tumor.
8 . The method of claim 4 , wherein said at least one radiotherapy device comprises two radiotherapy devices.
9 . The method of claim 1 , wherein said tumor is selected from the group consisting of a squamous cell carcinoma tumor (SCC tumor), a pancreatic carcinoma tumor and a colon carcinoma tumor.
10 . The method of claim 1 , wherein said chemotherapeutic agent is selected from the group consisting of cisplatin, gemcitabine, is 5-fluorouracil (5FU), taxol and doxorubicin.
11 . The method of claim 1 , wherein when said tumor is a SCC tumor, said chemotherapeutic agent is cisplatin.
12 . The method of claim 1 , wherein when said tumor is a pancreatic carcinoma tumor, said chemotherapeutic agent is gemcitabine.
13 . The method of claim 1 , wherein when said tumor is a colon carcinoma tumor, said chemotherapeutic agent is 5-fluorouracil (5FU).
14 . A method of treating a tumor of a subject, the method comprising administering to the subject a therapeutically effective amount of alpha particles and a chemotherapeutic agent, wherein said chemotherapeutic agent is administered systemically, wherein said alpha particles are administered by positioning a non-stable alpha-emitting radionuclide in proximity to and/or within the tumor, so as to administer a dose of alpha particles into the tumor and wherein said chemotherapeutic agent is selected from the group consisting of cisplatin, gemcitabine, 5-fluorouracil (5FU), taxol and doxorubicin, thereby treating the tumor of the subject.
15 . The method of claim 14 , wherein the tumor is a solid tumor.
16 . The method of claim 1 , wherein said chemotherapeutic agent is a single chemotherapeutic agent.
17 . The method of claim 14 , wherein said non-stable alpha-emitting radionuclide is selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220.
18 . The method of claim 14 , wherein said positioning of said non-stable alpha-emitting radionuclide is effected by at least one radiotherapy device having a surface whereby said alpha-emitting radionuclide is on or beneath said surface.
19 . The method of claim 18 , wherein said at least one radiotherapy device comprises a wire.
20 . The method of claim 14 , wherein said non-stable alpha-emitting radionuclide is comprised in a solution.
21 . The method of claim 14 , wherein said positioning is effected at the base of the tumor.
22 . The method of claim 18 , wherein said at least one radiotherapy device comprises two radiotherapy devices.
23 . The method of claim 14 , wherein said tumor is selected from the group consisting of a squamous cell carcinoma tumor (SCC tumor), a pancreatic carcinoma tumor and a colon carcinoma tumor.