Hemostatic agent
View Patent ↗A generally non-acidic hemostatic agent, having a relatively neutral pH comprising a magnesium compound, such as a magnesium chloride, a magnesium sulfate and/or a magnesium acetate based compound. The resultant agent is generally less caustic than previous agents, when using a similar amount of active material.
1. An aqueous dental hemostatic agent comprising:
at least one water-soluble magnesium salt selected from the group consisting of magnesium chloride, magnesium sulfate, magnesium acetate, magnesium citrate and combinations thereof, said at least one magnesium salt at between 40-60 weight percent of the agent;
an acidic compound;
a pH balancing compound between 2-15 weight percent of the agent;
and
KELTROL® T-630 xanthan gum at between 0.5-10.0 weight percent of the agent,
said agent having a pH value between about 3.0-8.0.
2. The hemostatic agent according to claim 1 wherein said at least one water-soluble magnesium salt comprises a first water-soluble magnesium salt and a second water-soluble magnesium salt, and wherein said first water-soluble magnesium salt comprises magnesium chloride.
3. The hemostatic agent according to claim 2 wherein said second water-soluble magnesium salt comprises magnesium sulfate or magnesium acetate.
4. The hemostatic agent according to claim 2 , wherein said first water-soluble magnesium salt comprises between about 1.0-50.0 weight percent of the hemostatic agent.
5. The hemostatic agent according to claim 3 wherein said second water-soluble magnesium salt comprises between about 0.5-40.0 weight percent of the hemostatic agent.
6. An aqueous, clear dental hemostatic agent comprising:
a first water-soluble magnesium compound comprising between 1.0-50.0 weight percent of the agent, and a second water-soluble magnesium compound comprising between 0.5-40.0 weight percent of the agent, the first and second water-soluble magnesium compounds selected from the group consisting of magnesium chloride, magnesium sulfate, magnesium acetate, and magnesium citrate, the combination of said first and second water-soluble magnesium compounds comprising between 40.0-60.0 weight percent of the agent;
a first acidic compound; and
a xanthan gum comprising between 0.5-10.0 weight percent,
said agent having a pH value between about 3.0-8.0;
wherein said dental hemostatic agent is a uniform composition with no suspended solids.
7. The agent according to claim 6 further comprising a polyol.
8. The agent according to claim 6 further comprising a second acidic compound.
9. The agent according to claim 1 , wherein said acidic compound is a dicarboxylic acid compound.
10. The agent according to claim 9 , wherein said dicarboxylic acid compound is selected from malonic acid and oxalic acid.
11. The agent according to claim 1 , wherein the pH balancing compound comprises triethanolamine at between 2.0-20 weight percent of the hemostatic agent.
12. The agent according to claim 6 , wherein said first acidic compound is a dicarboxylic acid compound.
13. The agent according to claim 12 , wherein said dicarboxylic acid compound is selected from malonic acid and oxalic acid.
14. The agent according to claim 6 , further comprising triethanolamine at between 2.0-20 weight percent of the hemostatic agent.
15. The agent according to claim 6 , wherein said first water-soluble magnesium compound is magnesium chloride and wherein said second water-soluble magnesium compound is magnesium sulfate.
16. A hemostatic agent obtained in a process comprising the steps of:
(a) dissolving at least one magnesium salt in a volume of water;
(b) combining at least one acidic compound with the mixture of step (a);
(c) adding a pH balancing compound to the mixture of step (b) and agitating to provide a clear solution;
(d) adding a polyol to the clear solution of step (c);
(e) adding KELTROL® T-630 xanthan gum to the mixture of step (d);
(f) agitating the mixture of step (e) to completely hydrate the xanthan gum, thereby forming a uniform clear gel with no suspended solids and a pH between about 3.0 and about 8.0, the uniform gel comprising:
about 40 weight percent to about 60 weight percent of the at least one magnesium salt;
about 0.1 weight percent to about 20 weight percent of the at least one acidic compound;
about 1 weight percent to about 20 weight percent of a sweetener;
up to about 20 weight percent of the pH balancing compound;
about 5 weight percent to about 25 weight percent of the polyol; and
about 0.5 weight percent to about 10.0 weight percent of the xanthan gum.
17. The hemostatic agent of claim 16 , wherein a first water-soluble magnesium salt is magnesium chloride and wherein a second water-soluble magnesium salt is magnesium sulfate.
18. The hemostatic agent of claim 16 , wherein said acidic compound is a dicarboxylic acid compound selected from malonic acid and oxalic acid.
19. The hemostatic agent of claim 16 , wherein the pH balancing compound is triethanolamine.
20. The hemostatic agent of claim 16 , wherein the said polyol is polyethylene oxide 400.