Compositions and methods for reversing rebound hyperemia
The invention generally relates to compositions and methods for inducing vasoconstriction with low incidence of rebound hyperemia. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.
1. A method of reversing rebound hyperemia comprising topically administering to a patient in need thereof a composition consisting essentially of brimonidine, wherein said brimonidine concentration is from between about 0.001% to about 0.025% weight by volume, wherein pH of said composition is between about 5.5 and about 6.5, and wherein said composition is formulated as an ocular drop.
2. The method of claim 1 , wherein said brimonidine is present at a concentration from between about 0.001% to about 0.035% weight by volume.
3. The method of claim 1 wherein said method further decreases ischemia, inflammation, and rebound hyperemia associated with α-1 agonist use.