Transcription factor modulating compounds and methods of use thereof

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Quick Facts

Patent No.: US 8,436,031
App. No.: 12/462,405
Granted: May 7, 2013
Kind: B2

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Abstract

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Claims (4)

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a transcription factor modulating compound, or a pharmaceutically acceptable salt thereof, wherein said compound is of the following formula

2. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

3. The pharmaceutical composition of claim 1 , further comprising an antibiotic.

Assignments (5)

TERMINATION OF LIEN ON PATENTS Recorded Dec 23, 2014

From: MCCARTER & ENGLISH, LLP

To: PARATEK PHARMACEUTICALS, INC.

Reel/Frame 034695/0958 →

RELEASE OF SECURITY INTEREST Recorded Oct 31, 2014

From: HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD., AS COLLATERAL AGENT

To: PARATEK PHARMACEUTICALS, INC.

Reel/Frame 034113/0910 →