Biocompatible and biodegradable elastomeric polymers

1. A biocompatible polymer comprising:

a) one or more ECM-mimetic peptides having the sequence amino acid sequence VPGVG as set forth in SEQ ID NO: 1; and

b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 Da.

2. A biocompatible polymer comprising:

a) one or more ECM-mimetic peptides; and

b) one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof;

wherein the polymer has a weight-average molecular weight of from about 1,000 Da to about 2,000,000 and has the formula:

wherein:

Mim is the ECM-mimetic peptide and has the formula:

-[X aa -X bb -X cc -X dd -X ee] x -

wherein Xaa, Xbb, Xcc, Xdd, and Xee are each independently an amino acid residue chosen from:

i) glycine or a conservative substitution thereof;

ii) valine or a conservative substitution thereof; and

iii) proline or a conservative substitution thereof;

wherein BioDeg is the non-amino acid or residue thereof containing one or more biodegradable moieties;

the index x is an integer from 1 to 30;

the index y is an integer from 1 to 10; and

the index z is an integer from 1 to 2000;

and wherein the polymer further comprises a biodegradable or non-biodegradable linker that links the one or more ECM-mimetic peptides to the one or more biodegradable moieties.

3. The polymer according to claim 2 , wherein the ECM-mimetic peptide comprises residues of amino acids chosen from alanine, γ-aminobutyric acid, 2-aminohexanoic acid, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, homoserine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, phenylglycine, proline, serine, threonine, tryptophan, tyrosine, and valine.

4. The polymer according to claim 2 , wherein the one or more ECM-mimetic peptides are chosen from:

i) Val-Pro-Gly-Val-Gly (SEQ ID NO: 1);

ii) Val-Pro-Gly-Gly-Val (SEQ ID NO: 2);

iii) Val-Pro-Val-Gly-Gly (SEQ ID NO: 3);

iv) Gly-Pro-Gly-Val-Val (SEQ ID NO: 4);

v) Gly-Pro-Val-Gly-Val (SEQ ID NO: 5);

vi) Gly-Pro-Val-Val-Gly (SEQ ID NO: 6);

vii) Pro-Val-Gly-Val-Gly (SEQ ID NO: 7);

viii) Pro-Val-Gly-Gly-Val (SEQ ID NO: 8);

ix) Pro-Val-Val-Gly-Gly (SEQ ID NO: 9);

x) Pro-Gly-Gly-Val-Val (SEQ ID NO: 10);

xi) Pro-Gly-Val-Gly-Val (SEQ ID NO: 11);

xii) Pro-Gly-Val-Val-Gly (SEQ ID NO: 12);

xiii) Val-Gly-Pro-Val-Gly (SEQ ID NO: 13);

xiv) Val-Gly-Pro-Gly-Val (SEQ ID NO: 14);

xv) Val-Val-Pro-Gly-Gly (SEQ ID NO: 15);

xvi) Gly-Gly-Pro-Val-Val (SEQ ID NO: 16);

xvii) Gly-Val-Pro-Gly-Val (SEQ ID NO: 17);

xviii) Gly-Val-Pro-Val-Gly (SEQ ID NO: 18);

xix) Val-Gly-Val-Pro-Gly (SEQ ID NO: 19);

xx) Val-Gly-Gly-Pro-Val (SEQ ID NO: 20);

xxi) Val-Val-Gly-Pro-Gly (SEQ ID NO: 21);

xxii) Gly-Gly-Val-Pro-Val (SEQ ID NO: 22);

xxiii) Gly-Val-Gly-Pro-Val (SEQ ID NO: 23);

xxiv) Gly-Val-Val-Pro-Gly (SEQ ID NO: 24);

xxv) Val-Gly-Val-Gly-Pro (SEQ ID NO: 25);

xxvi) Val-Gly-Gly-Val-Pro (SEQ ID NO: 26);

xxvii) Val-Val-Gly-Gly-Pro (SEQ ID NO: 27);

xxviii) Gly-Gly-Val-Val-Pro (SEQ ID NO: 28);

xxix) Gly-Val-Gly-Val-Pro (SEQ ID NO: 29); and

xxx) Gly-Val-Val-Gly-Pro (SEQ ID NO: 30).

5. The polymer according to claim 2 , having the formula:

wherein BioDeg is a residue of:

i) lactic acid;

ii) glycolic acid;

iii) lactide;

iv) glycolide;

v) caprolactone;

vi) hydroxybutyrate;

vii) valerolactone;

viii) a hydroxy acid;

ix) a hydroxy fatty acid;

x) lactide-co-glycolide;

xi) lactide-co-caprolactone;

xii) lactide-co-valerolactone;

xiii) glycolide-co-caprolactone;

xiv) glycolide-co-valerolactone;

xv) lactide-co-glycolide-co-caprolactone; or

xvi) lactide-co-glycolide-co-valerolactone;

the index t is an integer from 1 to 10;

the index y is an integer from 1 to 10; and

the index z is an integer from 1 to 2000.

6. The polymer according to claim 2 , having the formula:

wherein L is the biodegradable or non-biodegradable linker;

BioDeg comprises one or more residues of lactide, glycolide, valerolactone, caprolactone, hydroxybutyrate, or copolymers thereof;

y is an integer from 1 to 10; and

z is an integer from 1 to 2000 when the formula is i) or vi) and z is an integer from 2 to 2000 when the formula is ii) or iii).

7. The polymer according to claim 6 , wherein the linker L is formed by the reaction of Mim and BioDeg with a linking reagent and wherein the linker L comprises one or more chemical groups chosen from:

i) an alkyl;

ii) an alkoxy;

iii) a carbonyl;

iv) a halogen comprising leaving group;

v) an ester;

vi) an orthoester;

vii) an anhydride;

viii) a phosphate;

ix) a phosphazene;

x) a phosphoester;

xi) a dioxanone;

xii) a carbonate;

xiii) an orthocarbonate;

xiv) an amide;

xv) an amine;

xvi) an ester amide;

xvii) an isocyanate;

xviii) a urethane;

xix) an etherester;

xx) a pyrrolidone; or

xxi) a unit comprising a combination of two or more units (i) to (xx).

8. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is an integer from 1 to 10.

9. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

10. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

11. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

12. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

13. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

14. The polymer according to claim 6 , wherein the linker has the formula:

and the index t is from 1 to 10.

15. The polymer according to claim 2 , wherein the one or more ECM mimetic peptides comprises an elastin-mimetic, a fibrinogen-mimetic, a fibroin-mimetic, a silk-mimetic, a collagen-mimetic, a keratin-mimetic, or a mixture thereof.

16. An article comprising the biocompatible polymer of claim 2 .

17. The article of claim 16 , wherein the article is a stent, implant, film, foam, sponge, patch, matrix, fabric, mesh, membrane, or felt.

18. The article of claim 16 , wherein the article is a stent that is coated with the biocompatible polymer.

19. The article of claim 18 , further comprising a bioactive agent.