IP Library › Granted Patent US 8,481,801
Granted Patent B2
US 8,481,801 · App. 12/470,620 · Granted Jul 9, 2013

Fluid wound dressing comprising partially cured polyurethane

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Quick Facts
Patent No.
US 8,481,801
App. No.
12/470,620
Filed
May 22, 2009
Granted
Jul 9, 2013
Kind
B2
Examiner
LEWIS, KIM M
Art Unit
3772
USPC
602/46
Abstract

A wound dressing composition comprising a partially cured polyurethane fluid. The composition can be injected directly into a wound, where it cures to form a wound filling dressing. Also provided is a wound dressing comprising such a composition. Also provided is a kit for the preparation of such wound dressings, the kit comprising (a) a polyurethane prepolymer; and (b) a curing agent for the polyurethane prepolymer. Preferably, the polyurethane components comprise reaction products of a diisocyanate with castor oil or a related ester of ricinoleic acid or its derivatives.

Claims (13)

1. A wound dressing kit, comprising:

(a) a polyurethane prepolymer, comprising an isocyanate capped prepolymer and a compound selected from the group consisting of castor oil, other esters of ricinoleic acid, and derivatives thereof, wherein the polyurethane prepolymer is prepared by reacting a disocyanate with the compound selected from the group consisting of castor oil, glycerol mono- or diester of ricinoleic acid and other ricinoleic acid derivatives thereof; and

(b) a curing agent for the polyurethane prepolymer;

wherein components (a) and (b) are stored separately in a single package for mixing immediately before use to form a combined preparation; and

wherein a portion of the isocyanate capped prepolymer remains uncured resulting in a soft and flexible polyurethane having a dry tensile strength of at least 5N/cm 2 .

2. The wound dressing kit according to claim 1 , wherein the package comprises a barrier between the components that can be opened to allow the components to mix inside the package immediately before use.

3. The wound dressing kit according to claim 1 , wherein the package comprises a mixing chamber for sterile mixing of the components immediately before use.

4. The wound dressing kit of claim 3 further comprising a secondary dressing.

5. The wound dressing kit of claim 4 wherein the combined preparation is suitable for application directly from the mixing chamber onto a wound.

6. The wound dressing kit according to claim 1 , further comprising one or more of the group consisting of reinforcing elements, drainage elements, and a secondary dressing.

7. The wound dressing kit according to claim 1 , wherein component (a) and component (b) are both liquids at temperatures above 5° C.

8. The wound dressing kit according to claim 1 , wherein component (b) comprises a wound therapeutic material selected from the group consisting of antiseptics such as molecular silver, silver sulfadiazine or chlorhexidine; pain relieving agents such as lignocaine; anti-scarring agents such as mannose-6-phosphate, and agents for promoting wound healing such as growth factors, and mixtures thereof.

9. The wound dressing kit of claim 1 wherein component (b) further comprises a blowing agent.

Assignments (9)
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 7, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KCI USA, INC.; KCI LICENSING, INC.
Reel/Frame 050966/0547 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 6, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; TECHNIMOTION, LLC
Reel/Frame 050945/0278 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2019
From: BANK OF AMERICA, N.A.
To: KCI USA, INC.
Reel/Frame 050710/0955 →
RELEASE OF SECURITY INTEREST REEL/FRAME 040098/0268 Recorded Feb 8, 2017
From: WILMINGTON TRUST
To: KCI USA, INC.
Reel/Frame 041666/0320 →
SECURITY AGREEMENT Recorded Feb 7, 2017
From: KCI USA, INC., AS GRANTOR
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 041650/0013 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Feb 6, 2017
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: KCI LICENSING, INC., AS GRANTOR; TECHNIMOTION, LLC, A DELAWARE LIMITED LIABILITY COMPANY, AS GRANTOR; SYSTAGENIX WOUND MANAGEMENT (US), INC., A DELAWARE CORPORATION, AS GRANTOR
Reel/Frame 041395/0044 →
LIMITED THIRD LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Oct 7, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040291/0237 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 21, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040098/0268 →
SECURITY INTEREST Recorded Feb 17, 2016
From: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; LIFECELL CORPORATION; TECHNIMOTION, LLC
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 037845/0497 →