Pharmaceutical formulation
View Patent ↗The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.
1. A pharmaceutical composition comprising:
(a) from 1% to 20% by weight of a cholesterol absorption inhibitor;
(b) from 1% to 80% by weight of at least one HMG-CoA reductase inhibitor;
(c) from 0.005% to 10% by weight of ascorbic acid;
(d) croscarmellose sodium; and
(e) povidone.
2. The pharmaceutical composition according to claim 1 , wherein the cholesterol absorption inhibitor is ezetimibe.
3. The pharmaceutical composition according to claim 1 , wherein the HMG-Co-A reductase inhibitor is simvastatin or atorvastatin.