Spirocyclic heterocyclic derivatives and methods of their use
View Patent ↗Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
1. A compound of the following formula:
or a pharmaceutically acceptable salt or N-oxide thereof.
2. A compound according to claim 1 which is in the form of a pharmaceutically acceptable salt.
3. A compound according to claim 2 wherein the salt is a hydrochloride salt.
4. A pharmaceutical composition comprising the compound according to claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.