Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use
View Patent ↗Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use.
1. A crystalline hydrate of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol.
2. A crystalline anhydrite of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol.
3. A pharmaceutical composition comprising the crystalline hydrate of claim 1 .
4. A pharmaceutical composition comprising the crystalline anhydrate of claim 2 .
5. A method of reducing the number of circulating lymphocytes in a patient, which comprises administering to the patient an effective amount of the crystalline hydrate of claim 1 .
6. A method of reducing the number of circulating lymphocytes in a patient, which comprises administering to the patient an effective amount of the crystalline anhydrate of claim 2 .
7. A method of treating or managing rheumatoid arthritis, which comprises administering to a patient in need thereof a therapeutically effective amount of the crystalline hydrate of claim 1 .
8. A method of treating or managing rheumatoid arthritis, which comprises administering to a patient in need thereof a therapeutically effective amount of the crystalline anhydrate of claim 2 .