SILICONE SCAR TREATMENT PREPARATION
Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
1 ) A spreadable preparation for aiding in the healing of wounds, as well as improving the characteristics of the post-epithelialially developed tissue at the wound site, said preparation comprising:
a) a volatile component;
b) siloxane matrix precursors; wherein said precursors are capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component;
c) an active component having low miscibility and low solubility in said siloxane matrix precursors;
d) a volatile coagent;
wherein said volatile coagent is capable of forming a complex with said active component to form a solubilized active component; wherein the complex is miscible in said siloxane matrix precursors; and wherein all or a portion of said volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.
2 ) The spreadable preparation as in claim 1 wherein the volatile coagent is an ester of a linear acid having a carbon chain length in the range of from about 6 to 13 carbon atoms and methanol, ethanol, or a secondary alcohol having a total carbon content in the range of from about 3 to about 8 carbon atoms.
3 ) The spreadable preparation as in claim 1 wherein the volatile coagent is a glycol comprised of a linear chain of three or more carbons and one or more hydroxyl groups; and wherein all hydroxyl groups are on adjacent carbons including an end carbon.
4 ) The spreadable preparation as in claim 1 wherein the volatile coagent is a substituted or unsubstituted isosorbide.
5 ) The spreadable preparation as in claim 1 wherein the active component comprises an agent having sun screening activity.
6 ) The spreadable preparation as in claim 1 wherein the active component comprises an agent having antihistamine or pain relieving activity.
7 ) The spreadable preparation as in claim 5 wherein the active component comprises one or more of the following: Octocrylene (ISP Escalol 597), Octinoxate (ISP Escalol 557), Octisalate (ISP Escalol 587), or Oxybenzone (ISP Escalol 567).
8 ) The spreadable preparation as in claim 6 wherein the active component comprises Hydrocortisone Acetate USP.
9 ) The spreadable preparation as in claim 1 wherein the volatile coagent comprises Dimethyl isosorbide
10 ) The spreadable preparation as in claim 1 wherein the volatile coagent comprises isopropyl myristate.
11 ) The spreadable preparation as in claim 1 wherein the volatile coagent comprises pentylene glycol.
12 ) The spreadable preparation as in claim 6 wherein the volatile coagent comprises isopropyl myristate.
13 ) The spreadable preparation as in claim 8 wherein the volatile coagent comprises Dimethyl isosorbide
14 ) The spreadable preparation as in claim 13 wherein the volatile coagent comprises pentylene glycol.
15 ) The spreadable preparation as in claim 1 wherein the siloxane matrix precursors comprise dimethicone crosspolymer, fumed silica, and dimethicone.
16 ) A method as in claim 1 wherein the volatile component is cyclopentasiloxane.
17 ) A method for the preparation of a spreadable preparation for aiding in the healing of wounds and the development of scar tissue, said preparation comprising:
a) a volatile component;
b) siloxane matrix precursors; wherein said precursors are capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component;
c) an active component having low miscibility and low solubility in said siloxane matrix precursors;
d) a volatile coagent;
wherein said volatile coagent is capable of forming a complex with said active component to form a solubilized active component; wherein the complex is miscible in said siloxane matrix precursors; and wherein all or a portion of said volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.
said method comprising the steps of:
a) providing said active component
b) providing said volatile coagent
c) providing siloxane matrix precursors
d) forming a complex between the volatile coagent and said active component which is miscible.
18 ) The method of claim 17 wherein the siloxane matrix precursors comprise dimethicone crosspolymer, fumed silica, and dimethicone and the volatile component comprises cyclopentasiloxane.
19 ) The method of claim 17 wherein the volatile coagent comprises isopropyl myristate and the active component comprises one or more of the following: Octocrylene (ISP Escalol 597), Octinoxate (ISP Escalol 557), Octisalate (ISP Escalol 587), or Oxybenzone (ISP Escalol 567).
20 ) The method of claim 17 wherein the volatile coagent comprises pentylene glycol and/or dimethyl isosorbide and the active component comprises Hydrocortisone Acetate.