Compositions and methods of use of ORF1358 from beta-hemolytic streptococcal strains
View Patent ↗The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.
1. An isolated polypeptide that comprises an amino acid sequence that is at least 98% identical to the amino acid sequence set forth in SEQ ID NO: 26.
2. An immunogenic composition comprising an isolated polypeptide that comprises:
a) an amino acid sequence that is at least 98% identical to the amino acid sequence set forth in SEQ ID NO: 26; or
b) the amino acid sequence of SEQ ID NO: 26.
3. A kit comprising an isolated polypeptide that comprises an amino acid sequence that is at least 98% identical to the amino acid sequence set forth in SEQ ID NO: 26.