IP Library › Granted Patent US 8,404,194
Granted Patent B2
US 8,404,194 · App. 12/491,891 · Granted Mar 26, 2013

Blood separation media

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Quick Facts
Patent No.
US 8,404,194
App. No.
12/491,891
Granted
Mar 26, 2013
Kind
B2
Abstract

Disclosed is a separation media, comprising an upstream layer, comprising fibers, wherein the upstream layer has a mean flow pore size of 8 microns or less; and a downstream layer, comprising fibers. The separation media is designed to separate red blood cells from liquid specimens such as blood and allow a filtrate, such as blood plasma, to flow from said downstream layer. Also provided is a diagnostic test device incorporating the separation media. Further disclosed is a method for separating red blood cells from a liquid specimen.

Claims (13)

1. A blood separation media for separating blood into red blood cells and a remaining portion, comprising:

a planar upstream layer, comprising fibers, wherein said upstream layer has a mean flow pore size of 8 microns or less, wherein the upstream layer is configured to prevent passage of the red blood cells so as to separate the red blood cells via capillary action from the remaining portion; and

a planar downstream layer, comprising fibers, wherein said downstream layer is designed to allow for flow of fluids therethrough,

wherein said upstream layer and said downstream layer overlap each other.

2. The separation media of claim 1 , wherein one or both of said upstream layer and said downstream layer comprise microglass fibers.

3. The separation media of claim 1 , wherein one or both of said upstream layer and said downstream layer is substantially free of binder.

4. The separation media of claim 1 , wherein said media is capable of removing red blood cells from a specimen.

5. The separation media of claim 4 , wherein said specimen is blood.

6. The separation media of claim 1 , wherein if a liquid specimen containing red blood cells is applied to said upstream layer, substantially all of said red blood cells will be prevented from flowing into said downstream layer.

7. The separation media of claim 6 , wherein after substantially all of said red blood cells are prevented from flowing into said downstream layer, a filtrate of said liquid specimen flows at a predetermined rate and volume into and through said downstream layer.

8. The separation media of claim 6 , wherein said liquid specimen comprises blood.

9. The separation media of claim 7 , wherein said liquid specimen comprises blood and said filtrate comprises blood plasma.

10. The separation media of claim 6 , wherein said red blood cells are not ruptured by said media.

Assignments (14)
RELEASE OF FIRST LIEN SECURITY INTEREST IN PATENT COLLATERAL AT REEL/FRAME NO. 57683/0044 Recorded Oct 2, 2024
From: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
To: LYDALL, INC.
Reel/Frame 069103/0619 →
SECOND LIEN TRADEMARK SECURITY AGREEMENT Recorded Oct 2, 2024
From: LYDALL PERFORMANCE MATERIALS (US), INC.; LYDALL INC.; REFRACTORY SPECIALTIES, INCORPORATED; SOUTHERN FELT COMPANY, INC.; UNIFRAX I LLC; STELLAR MATERIALS
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS SECOND LIEN NOTES COLLATERAL AGENT
Reel/Frame 069091/0923 →
FIRST LIEN PATENT SECURITY AGREEMENT Recorded Oct 2, 2024
From: LYDALL PERFORMANCE MATERIALS (US), INC.; LYDALL INC.; REFRACTORY SPECIALTIES, INCORPORATED; SOUTHERN FELT COMPANY, INC.; UNIFRAX I LLC; STELLAR MATERIALS
To: WILMINGTON SAVINGS FUND SOCIETY, FSB, AS COLLATERAL AGENT
Reel/Frame 069091/0735 →
SECURITY INTEREST Recorded Oct 15, 2021
From: LYDALL, INC.; SOUTHERN FELT COMPANY, INC.; LYDALL PERFORMANCE MATERIALS (US), INC.
To: WILMINGTON TRUST
Reel/Frame 057826/0962 →
RELEASE OF SECURITY INTEREST Recorded Oct 12, 2021
From: BANK OF AMERICA, N.A.
To: LYDALL, INC.
Reel/Frame 057761/0580 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2021
From: BANK OF AMERICA, N.A.
To: LYDALL, INC.
Reel/Frame 057753/0123 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2021
From: BANK OF AMERICA, N.A.
To: LYDALL, INC.
Reel/Frame 057751/0905 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2021
From: BANK OF AMERICA, N.A.
To: LYDALL, INC.
Reel/Frame 057752/0321 →
FIRST LIEN PATENT SECURITY AGREEMENT Recorded Oct 1, 2021
From: LYDALL, INC.
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 057683/0044 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Apr 26, 2021
From: LYDALL, INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 056107/0341 →
SECOND AMENDED AND RESTATED PATENT COLLATERAL ASSIGNMENT AND SECURITY AGREEMENT Recorded Aug 31, 2018
From: LYDALL, INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 047570/0702 →
AMENDED AND RESTATED PATENT COLLATERAL ASSIGNMENT AND SECURITY AGREEMENT Recorded Feb 20, 2014
From: LYDALL, INC.
To: BANK OF AMERICA, N.A., ON BEHALF OF ITSELF AND AS AGENT, SUCCESSOR IN INTEREST TO BANK OF AMERICA, N.A.
Reel/Frame 032298/0178 →
PATENT COLLATERAL ASSIGNMENT AND SECURITY AGREEMENT Recorded Jun 21, 2011
From: LYDALL, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 026467/0017 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2009
From: SAXENA, ABHISHEK D.; RAMSAY, JOHN C.
To: LYDALL, INC.
Reel/Frame 023204/0629 →