Tanaproget derivatives, metabolites, and uses thereof
View Patent ↗A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
1. A kit for monitoring therapy with tanaproget, said kit comprising a standard comprising a synthetic S-glucuronide of tanaproget of the following structure:
2. A kit for detecting metabolites of tanaproget, said kit comprising packaging and a standard comprising a composition comprising an enzymatically derived tananroget S-glucuronide of the following structure:
3. A composition comprising a pharmaceutically acceptable carrier and a synthetic N-glucuronide of tanaproget of the following structure:
4. A kit for monitoring therapy with tanaproget, said kit comprising a standard comprising a synthetic N-glucuronide of tanaproget of the following structure:
5. A composition useful in an assay for monitoring tanaproget therapy in a subject, said composition comprising a tanaproget metabolite selected from the group consisting of:
(a) tanaproget having a sulfate moiety located on the thiocarbonyl group;
(b) tanaproget having a hydroxy group located on the pyrrole ring;
(c) tanaproget having a hydroxy group located on the phenylpyrrole ring; and
(d) tanaproget having a carbamate located on the thiocarbonyl group.
6. A kit for detecting metabolites of tanaproget, said kit comprising packaging and a standard comprising a composition according to claim 5 .