Functionalized inclusion complexes as crosslinkers
View Patent ↗The present disclosure relates to crosslinked polymer compositions comprising an inclusion complex functionalized with one or more reactive groups and a polymer functionalized with one or more complimentary reactive groups.
1. A composition comprising:
an inclusion complex functionalized with one or more reactive groups, and a polymer functionalized with one or more complimentary reactive groups capable of covalently bonding with the reactive groups present on the inclusion complex, wherein the inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.
2. The composition of claim 1 wherein the one or more cyclic oligosaccharides is a cyclodextrin.
3. The composition of claim 1 wherein the one or more multi-armed polymer chain is a multi-arm polyethylene glycol.
4. The composition of claim 1 wherein the functionalized inclusion complex comprises one or more reactive groups selected from the group consisting of electrophilic groups, nucleophilic groups and combinations thereof.
5. The composition of claim 1 wherein the functionalized polymer comprises one or more complimentary reactive groups selected from the group consisting of electrophilic groups, nucleophilic groups and combinations thereof.
6. The composition of claim 1 wherein the functionalized inclusion complex further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.
7. The composition of claim 1 wherein the functionalized polymer further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.
8. A composition comprising:
an inclusion complex functionalized with one or more electrophilic groups, and a polymer functionalized with one or more nucleophilic groups, wherein the inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains and wherein the one or more nucleophilic groups is capable of covalently bonding with the one or more electrophilic groups.
9. The composition of claim 8 wherein the one or more cyclic oligosaccharide is a cyclodextrin.
10. The composition of claim 8 wherein the one or more multi-armed polymer chain is a multi-arm polyethylene glycol.
11. The composition of claim 8 wherein the functionalized inclusion complex comprises electrophilic groups selected from the group consisting of —CO 2 N(COCH 2 ) 2 , —CO 2 H, —CHO, —CHOCH 2 , —N═C═O, —SO 2 CH═CH 2 , —N(COCH) 2 , —S—S—(C 5 H 4 N), and combinations thereof.
12. The composition of claim 8 wherein the functionalized polymer comprises one or more nucleophilic groups selected from the group consisting of —NH 2 , —SH, —OH, —PH 2 , —CO—NH—NH 2 and combinations thereof.
13. The composition of claim 8 wherein the functionalized inclusion complex further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.
14. The composition of claim 8 wherein the functionalized polymer further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.
15. A composition comprising:
an inclusion complex functionalized with one or more nucleophilic groups, and a polymer functionalized with one or more electrophilic groups, wherein the inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains and wherein the one or more nucleophilic groups is capable of covalently bonding with the one or more electrophilic groups.
16. The composition of claim 15 wherein the one or more cyclic oligosaccharide is a cyclodextrin.
17. The composition of claim 15 wherein the one or more multi-armed polymer chain is a multi-arm polyethylene glycol.
18. The composition of claim 15 wherein the functionalized inclusion complex comprises electrophilic groups selected from the group consisting of —CO 2 N(COCH 2 ) 2 , —CO 2 H, —CHO, —CHOCH 2 , —N═C═O, —SO 2 CH═CH 2 , —N(COCH) 2 , —S—S—(C 5 H 4 N), and combinations thereof.
19. The composition of claim 15 wherein the functionalized polymer comprises one or more nucleophilic groups selected from the group consisting of —NH 2 , —SH, —OH, —PH 2 , —CO—NH—NH 2 and combinations thereof.
20. A composition comprising:
a first inclusion complex functionalized with one or more nucleophilic groups, and a second inclusion complex functionalized with one or more electrophilic groups, wherein at least one of the first inclusion complex and the second inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains and wherein the one or more nucleophilic groups is capable of covalently bonding with the one or more electrophilic groups.
21. A method for preparing a composition comprising the steps of:
providing an inclusion complex functionalized with one or more electrophilic groups and a polymer functionalized with one or more nucleophilic groups;
forming a mixture by mixing the functionalized inclusion complex with the functionalized polymer to initiate crosslinking; and
allowing the functionalized inclusion complex and the functionalized polymer to continue crosslinking to form a crosslinked polymer composition, wherein the inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.
22. A composition comprising:
an inclusion complex functionalized with one or more reactive groups, and a polymer functionalized with one or more complimentary reactive groups capable of covalently bonding with the reactive groups present on the inclusion complex, wherein the functionalized inclusion complex further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof, wherein the inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.