IP Library › Granted Patent US 8,628,777
Granted Patent B2
US 8,628,777 · App. 12/495,633 · Granted Jan 14, 2014

Antibodies binding IL-1 related polypeptides

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Quick Facts
Patent No.
US 8,628,777
App. No.
12/495,633
Granted
Jan 14, 2014
Kind
B2
Abstract

The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

Claims (4)

1. An isolated monoclonal antibody which specifically binds to residues 15 to 25 of the N-terminal region of the IL-1lp polypeptide of FIG. 3 (SEQ ID NO:7).

2. A composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.

3. An isolated monoclonal antibody which specifically binds to residues 2 to 25 of the N-terminal region of the IL-1lp polypeptide encoded by the human cDNA insert of ATCC Deposit No. 203587.

4. A composition comprising the antibody of claim 3 and a pharmaceutically acceptable carrier.