IP Library › Granted Patent US 7,915,236
Granted Patent B2
US 7,915,236 · App. 12/496,359 · Granted Mar 29, 2011

Proteasome inhibitors and methods of using the same

Assignee: Cephalon, Inc.
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Quick Facts
Patent No.
US 7,915,236
App. No.
12/496,359
Granted
Mar 29, 2011
Kind
B2
Abstract

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Claims (2438)

1. A compound of Formula (I)

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 3 -C 7 cycloalkyl;

R 2 is —(CH 2 ) a CH 2 NHC(═NR 4 )NH—Y, —(CH 2 ) b CH 2 CONR 5 R 6 , —(CH 2 ) c CH 2 N(R 4 )CONH 2 , —(CH 2 ) d CH(R 7 )NR 9 R 10 , or —(CH 2 ) e CH(R 7 )ZR 8 ;

a, b, and c are each, independently, 0, 1, 2, 3, 4, 5, or 6;

d and e are each, independently, 0, 1, 2, 3, or 4;

R 4 is H or C 1 -C 10 alkyl;

R 5 and R 6 are each, independently, H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, or an amino protecting group;

alternatively, R 5 and R 6 together with the N atom to which they are attached form a heterocarbocyclyl group;

R 7 is H or C 1 -C 10 alkyl;

R 8 is H, C 1 -C 10 alkyl, alkyl-S(═O) 2 —, aryl-S(═O) 2 —, H 2 NS(═O) 2 —, —SO 3 H, or a protecting group;

R 9 is H, C 1 -C 10 alkyl, carbocyclyl, or heterocarbocyclyl;

R 10 is H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, C 1 -C 10 alkyl-C(═O)—,

C 2 -C 10 alkenyl-C(═O)—, C 2 -C 10 alkynyl-C(═O)—, carbocyclyl-C(═O)—, heterocarbocyclyl-C(═O)—, carbocyclylalkyl-C(═O)—,

heterocarbocyclylalkyl-C(═O)—, C 1 -C 10 alkyl-S(═O) 2 —, carbocyclyl-S(═O) 2 —,

heterocarbocyclyl-S(═O) 2 —, carbocyclylalkyl-S(═O) 2 —, heterocarbocyclylalkyl-S(═O) 2 —, C 1 -C 10 alkyl-NHC(═O)—,

carbocyclyl-NHC(═O)—, heterocarbocyclyl-NHC(═O)—,

carbocyclylalkyl-NHC(═O)—, heterocarbocyclylalkyl-NHC(═O)—,

C 1 -C 10 alkyl-OC(═O)—, carbocyclyl-OC(═O)—, heterocarbocyclyl-OC(═O)—, carbocyclylalkyl-OC(═O)—, heterocarbocyclylalkyl-OC(═O)—,

C 1 -C 10 alkyl-NH—C(═O)—NHS(═O) 2 —, carbocyclyl-NH—C(═O)—NHS(═O) 2 —, heterocarbocyclyl-NH—C(═O)—NHS(═O) 2 —, alkyl-S(═O) 2 —NH—C(═O)—, carbocyclyl-S(═O) 2 —NH—C(═O)—, heterocarbocyclyl-S(═O) 2 —NH—C(═O)—, or an amino protecting group; wherein R 10 is optionally substituted with 1, 2 or 3, R 23 ;

alternatively, R 9 and R 10 together with the N atom to which they are attached form a heterocarbocyclyl group optionally substituted with 1, 2 or 3 R 23 ;

Y is H, —CN, —NO 2 , —S(═O) 2 R 11 , or a guanidino protecting group;

R 11 is C 1 -C 6 alkyl, aryl, or NR 12 R 13 ;

R 12 and R 13 are, independently, H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, or an amino protecting group;

alternatively, R 12 and R 13 together with the N atom to which they are attached form a heterocarbocyclyl group;

Z is O, S, Se, or Te;

Q is —B(OH) 2 , —B(OR 14 ) 2 , or a cyclic boronic ester wherein said cyclic boronic ester contains from 2 to 20 carbon atoms, and, optionally, a heteroatom which can be N, S, or O;

R 14 is H, C 1 -C 4 alkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, R A C(═O)—, R A SC(═O)—, or R A ;

morpholino, thiomorpholino, piperazinyl, tetrahydrofuranyl, tetrahydrothienyl, piperidinyl, pyrrolidinyl, isoxazolidinyl, isothiazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, imidazolidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, 1,2,4-thiadiazolyl, isothiazolyl, or purinyl, each optionally substituted with 1-5 R 21 ;

R 20 is selected from the group consisting of:

—CN, halo, haloalkyl-, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,

—CO 2 H, —C(═O)CO 2 H, —C(═O)NH 2 , —C(═O)H, —S(═O)NH 2 , —S(═O) 2 NH 2 ,

—OH, —SH, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)NH 2 ,

—NHC(═O)R 20a , —NHC(═O)OR 20a , —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a ,

—S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a ,

—C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHR 20b , phthalimido,

—(O-alkyl) r -OH, —(O-alkyl) r -(O-alkyl),

—OR 20c , —SR 20c , —O-alkyl-R 20c , —S-alkyl-R 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c ,

—S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c ,

carbocyclyl optionally substituted with 1-5 R 21 ; and

heterocarbocyclyl optionally substituted with 1-5 R 21 ;

R 20a C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or

alkynyl is optionally substituted by one or more halo, OH, CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 8 alkoxyalkoxy, aryl, heteroaryl or —NHR 20b ;

R 20b is an amino protecting group;

R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21 is selected from the group consisting of:

C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, —OR 21a , —SR 21a ,

—CN, halo, haloalkyl, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)O-alkyl,

—NHC(═O)alkyl, —COOH, —C(═O)O-alkyl, —C(═O)alkyl, —C(O)H,

—S(═O)-alkyl, —S(═O) 2 -alkyl, —S(═O)-aryl, —S(═O) 2 -aryl,

carbocyclyl optionally substituted with 1-5 R 22 , and

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21a is H, C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, carbocyclyl or heterocarbocyclyl;

R 22 is selected from the group consisting of:

C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 -alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —;

R 23 is selected from the group consisting of:

C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, F, Cl, Br, I, haloalkyl, —NH 2 ,

—NHR 23a , —N(R 23a ) 2 , N 3 , —NO 2 , —CN, —CNO, —CNS, —C(═O)OR 23a , —C(═O)R 23a ,

—OC(═O)R 23a , —N(R 23a )C(═O)R 23a , —N(R 23a )C(═O)OR 23a , —C(═O)N(R 23a ) 2 ,

ureido, —OR 23a , —SR 23a , —S(═O)—(C 1 -C 6 alkyl), —S(═O) 2 —(C 1 -C 6 alkyl),

—S(═O)-aryl, —S(═O) 2 -aryl, —S(═O) 2 —N(R 23a ) 2 ;

carbocyclyl optionally substituted with 1-5 R 24 ; and

heterocarbocyclyl optionally substituted with 1-5 R 24 ;

R 23a is H or C 1 -C 6 alkyl;

alternatively, two R 23a may be combined, together with the N atom to which they are attached, to form a 5 to 7 membered heterocyclic group; and

R 24 is selected from the group consisting of:

C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —; and

r is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;

with the proviso that when Q is a 1,1,2,2-tetramethylethanediol boronic ester, then X is not aralkyloxycarbonyl; and

with the proviso that when Q is a 1,1,2,2-tetramethylethanediol boronic ester, and R 1 is cycloalkyl, then R 2 is not —CH 2 CONH 2 .

2. The compound of claim 1 wherein R 1 is C 1 -C 4 alkyl.

3. The compound of claim 1 wherein R 1 is 2-propyl.

4. The compound of claim 1 wherein R 2 is —(CH 2 ) a CH 2 NHC(═NR 4 )NH—Y, —(CH 2 ) b CH 2 CONR 5 R 6 , —(CH 2 ) c CH 2 N(R 4 )CONH 2 , —(CH 2 ) d CH(R 7 )NR 9 R 10 , or —(CH 2 ) e CH(R 7 )ZR 8 .

5. The compound of claim 1 wherein R 2 is —(CH 2 ) a CH 2 NHC(═NR 4 )NH—Y.

6. The compound of claim 5 wherein a is 1, 2, 3, or 4.

7. The compound of claim 5 wherein a is 2.

8. The compound of claim 1 wherein R 2 is —(CH 2 ) d CH(R 7 )NR 9 R 10 .

9. The compound of claim 8 wherein d is 0, 1, or 2.

10. The compound of claim 8 wherein d is 0.

11. The compound of claim 8 wherein R 9 is H.

12. The compound of claim 1 wherein R 2 is —(CH 2 ) e CH(R 7 )ZR 8 .

13. The compound of claim 12 wherein Z is O.

14. The compound of claim 13 wherein e is 0, 1, or 2.

15. The compound of claim 13 wherein e is 0.

16. The compound of claim 1 wherein Q is B(OH) 2 or a cyclic boronic ester wherein said cyclic boronic ester contains from 6 to 10 carbon atoms and contains at least one cycloalkyl moiety.

17. The compound of claim 16 wherein Q is pinanediol boronic ester.

18. The compound of claim 16 wherein Q is bicyclohexyl-1,1′-diol boronic ester.

19. The compound of claim 16 wherein Q is 1,2-dicyclohexyl-ethane-1,2-diol boronic ester.

20. The compound of claim 1 wherein X is R A C(═O)—.

21. The compound of claim 1 wherein X is R A NHC(═O)—.

22. The compound of claim 1 wherein X is R A S(═O) 2 —.

23. The compound of claim 1 wherein R 2 is —CH 2 NH—C(═O)OCH 2 (C 6 H 5 ).

24. A compound of claim 1 of Formula (I):

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 3 -C 7 cycloalkyl;

R 2 is —(CH 2 ) a CH 2 NHC(═NR 4 )NH—Y, —(CH 2 ) b CH 2 CONR 5 R 6 ,

—(CH 2 ) c CH 2 N(R 4 )CONH 2 , —(CH 2 ) d CH(R 7 )NR 9 R 10 , or —(CH 2 ) e CH(R 7 )ZR 8 ;

a, b, and c are each, independently, 0, 1, 2, 3, 4, 5, or 6;

d and e are each, independently, 0, 1, 2, 3, or 4;

R 4 is H or C 1 -C 10 alkyl;

R 5 and R 6 are each, independently, H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, or an amino protecting group;

alternatively, R 5 and R 6 together with the N atom to which they are attached form a heterocarbocyclyl group;

R 7 is H or C 1 -C 10 alkyl;

R 8 is H, C 1 -C 10 alkyl, alkyl-S(═O) 2 —, aryl-S(═O) 2 —, H 2 NS(═O) 2 —, —SO 3 H, or a protecting group;

R 9 is H, C 1 -C 10 alkyl, carbocyclyl, or heterocarbocyclyl;

R 10 is H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, C 1 -C 10 alkyl-C(═O)—, carbocyclyl-C(═O)—, heterocarbocyclyl-C(═O)—, carbocyclylalkyl-C(═O)—, heterocarbocyclylalkyl-C(═O)—, C 1 -C 10 alkyl-S(═O) 2 —, carbocyclyl-S(═O) 2 —, heterocarbocyclyl-S(═O) 2 —, carbocyclylalkyl-S(═O) 2 —, heterocarbocyclylalkyl-S(═O) 2 —, C 1 -C 10 alkyl-NHC(═O)—, carbocyclyl-NHC(═O)—, heterocarbocyclyl-NHC(═O)—, carbocyclylalkyl-NHC(═O)—, heterocarbocyclylalkyl-NHC(═O)—, C 1 -C 10 alkyl-OC(═O)—, carbocyclyl-OC(═O)—, heterocarbocyclyl-OC(═O)—, carbocyclylalkyl-OC(═O)—, heterocarbocyclylalkyl-OC(═O)—, or an amino protecting group; wherein R 10 is optionally substituted with 1, 2, or 3 R 23 ;

alternatively, R 9 and R 10 together with the N atom to which they are attached form a heterocarbocyclyl group;

Y is —H, —CN, —NO 2 , —S(═O) 2 R 11 , or a guanidino protecting group;

R 11 is C 1 -C 6 alkyl, aryl, or NR 12 R 13 ;

R 12 and R 13 are, independently, H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, or an amino protecting group;

alternatively, R 12 and R 13 together with the N atom to which they are attached form a heterocarbocyclyl group;

Z is O, S, Se, or Te;

Q is —B(OH) 2 , —B(OR 14 ) 2 , or a cyclic boronic ester wherein said cyclic boronic ester contains from 2 to 20 carbon atoms, and, optionally, a heteroatom which can be N, S, or O;

R 14 is H, C 1 -C 4 alkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, R A C(═O)—, R A SC(═O)—, or R A ;

R A is

morpholino, thiomorpholino, piperazinyl, tetrahydrofuranyl, tetrahydrothienyl, piperidinyl, pyrrolidinyl, isoxazolidinyl, isothiazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, imidazolidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, 1,2,4-thiadiazolyl, isothiazolyl, or purinyl, each optionally substituted with 1-2 R 21 ;

R 20 is selected from the group consisting of:

—CN, halo, haloalkyl-, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,

—CO 2 H, —C(═O)CO 2 H, —C(═O)NH 2 , —C(═O)H, —S(═O)NH 2 , —S(═O) 2 NH 2 ,

—OH, —SH, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)NH 2 ,

—NHC(═O)R 20a , —NHC(═O)OR 20a , —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a ,

—S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a ,

—C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHR 20b , phthalimido,

—(—O-alkyl) r , —O-alkyl-OH, —(O-alkyl) r -OH,

—OR 20c , —SR 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c ,

—S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c ,

carbocyclyl optionally substituted with 1-5 R 21 ; and

heterocarbocyclyl optionally substituted with 1-5 R 21 ;

R 20a is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or alkynyl is optionally substituted by one or more halo, C 1 -C 4 alkyl, aryl, heteroaryl or —NHR 20b ;

R 20b is an amino protecting group;

R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21 is selected from the group consisting of:

C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkoxy,

C 1 -C 20 thialkoxy, —OH, —CN, halo, haloalkyl, —NH 2 , —NH(alkyl), —N(alkyl) 2 ,

—NHC(═O)O-alkyl, —NHC(═O)alkyl, —C(═O)O-alkyl, —C(═O)alkyl,

—S(═O)-alkyl, —S(═O) 2 -alkyl, —S(═O)-aryl, —S(═O) 2 -aryl,

carbocyclyl optionally substituted with 1-5 R 22 ; and

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 22 is selected from the group consisting of:

C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —;

R 23 is selected from the group consisting of:

C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, F, Cl, Br, I, haloalkyl, —NH 2 ,

—NHR 23a , —N(R 23a ) 2 , —N 3 , —NO 2 , —CN, —CNO, —CNS, —C(═O)OR 23a , —C(═O)R 23a , —OC(═O)R 23a , —N(R 23a )C(═O)R 23a , —C(═O)N(R 23a ) 2 , ureido, —OR 23a , —SR 23a , —S(═O) 2 —(C 1 -C 6 alkyl), —S(═O) 2 -aryl, and —S(═O) 2 —N(R 23a ) 2 ;

R 23a is H or C 1 -C 6 alkyl;

alternatively, two R 23a may be combined, together with the N atom to which they are attached, to form a 5 to 7 membered heterocyclic group; and

r is 2, 3, 4, 5, 6, 7, 8, 9, or 10; and

with the proviso that when Q is a 1,1,2,2-tetramethylethanediol boronic ester, then X is not aralkyloxycarbonyl; and

with the proviso that when Q is a 1,1,2,2-tetramethylethanediol boronic ester, and R 1 is cycloalkyl, then R 2 is not —CH 2 CONH 2 .

25. The compound of claim 24 wherein R 1 is 2-propyl.

26. The compound of claim 24 wherein Q is —B(OH) 2 .

27. The compound of claim 24 wherein Q is pinanediol boronic ester.

28. The compound of claim 24 wherein X is R A C(═O)—.

29. The compound of claim 24 wherein R 2 is —CH 2 NH—C(═O)OCH 2 (C 6 H 5 ).

30. A compound of claim 1 having Formula (I):

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is C 1 -C 8 alkyl;

R 2 is —(CH 2 ) a CH 2 NHC(═NH)NH—Y, —(CH 2 ) c CH 2 NHCONH 2 , —(CH 2 ) d CH(R 7 )NR 9 R 10 ,

or —(CH 2 ) e CH(R 7 )ZR 8 ;

a is 1, 2, 3, 4, or 5;

c is 1, 2, 3, 4, or 5;

d is 0, 1, or 2;

e is 0, 1, or 2;

R 7 is H or methyl;

R 8 is H, C 1 -C 10 alkyl, —S(═O) 2 -alkyl, —S(═O) 2 -aryl, —S(═O) 2 —NH 2 , —SO 3 H, or a protecting group;

Y is —H, —CN, —NO 2 , —S(═O) 2 R 11 , or a guanidino protecting group;

R 9 is H, C 1 -C 10 alkyl, carbocyclyl, or heterocarbocyclyl;

R 10 is H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, C 1 -C 10 alkyl-C(═O)—, carbocyclyl-C(═O)—, heterocarbocyclyl-C(═O)—, carbocyclylalkyl-C(═O)—, heterocarbocyclylalkyl-C(═O)—, C 1 -C 10 alkyl-S(═O) 2 —, carbocyclyl-S(═O) 2 —, heterocarbocyclyl-S(═O) 2 —, carbocyclylalkyl-S(═O) 2 —,

heterocarbocyclylalkyl-S(═O) 2 —, C 1 -C 10 alkyl-NHC(═O)—,

carbocyclyl-NHC(═O)—, heterocarbocyclyl-NHC(═O)—,

carbocyclylalkyl-NHC(═O)—, heterocarbocyclylalkyl-NHC(═O)—,

C 1 -C 10 alkyl-OC(═O)—, carbocyclyl-OC(═O)—, heterocarbocyclyl-OC(═O)—, carbocyclylalkyl-OC(═O)—, heterocarbocyclylalkyl-OC(═O)—, or an amino protecting group; wherein R 10 is optionally substituted with 1, 2 or 3 R 23 ;

alternatively, R 9 and R 10 together with the N atom to which they are attached form a heterocarbocyclyl group;

R 11 is C 1 -C 6 alkyl, aryl, or NR 12 R 13 ;

R 12 and R 13 are, independently, H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, or an amino protecting group;

alternatively, R 12 and R 13 together with the N atom to which they are attached form a heterocarbocyclyl group;

Z is O or S;

Q is —B(OH) 2 , —B(OR 14 ) 2 , or a cyclic boronic ester wherein said cyclic boronic ester contains from 6 to 20 carbon atoms and contains at least one cycloalkyl moiety;

R 14 is H, C 1 -C 4 alkyl, or cycloalkyl;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, R A C(═O)—, R A SC(═O)—, or R A ;

R A is

morpholino, thiomorpholino, piperazinyl, tetrahydrofuranyl, tetrahydrothienyl, piperidinyl, pyrrolidinyl, isoxazolidinyl, isothiazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, imidazolidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, 1,2,4-thiadiazolyl, isothiazolyl, or purinyl, each optionally substituted with 1-2 R 21 ;

R 20 is selected from the group consisting of:

—CN, halo, haloalkyl-, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,

—CO 2 H, —C(═O)CO 2 H, —C(═O)NH 2 , —C(═O)H, —S(═O)NH 2 , —S(═O) 2 NH 2 ,

—OH, —SH, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)NH 2 ,

—NHC(═O)R 20a , —NHC(═O)OR 20a , —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a ,

—S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a ,

—C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHR 20b , phthalimido,

—(O-alkyl) r , —O-alkyl-OH, —(O-alkyl) r -OH,

—OR 20c , —SR 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c ,

—S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c ,

carbocyclyl optionally substituted with 1-5 R 21 ; and

heterocarbocyclyl optionally substituted with 1-5 R 21 ;

R 20a is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or alkynyl is optionally substituted by one or more halo, C 1 -C 4 alkyl, aryl, heteroaryl or —NHR 20b ;

R 20b is an amino protecting group;

R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21 is selected from the group consisting of:

C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkoxy,

C 1 -C 20 thialkoxy, —OH, —CN, halo, haloalkyl, —NH 2 , —NH(alkyl), —N(alkyl) 2 ,

—NHC(═O)O-alkyl, —NHC(═O)alkyl, —C(═O)O-alkyl, —C(═O)alkyl,

—S(═O)-alkyl, —S(═O) 2 -alkyl, —S(═O)-aryl, —S(═O) 2 -aryl,

carbocyclyl optionally substituted with 1-5 R 22 , and

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 22 is selected from the group consisting of:

C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —;

R 23 is selected from the group consisting of:

C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, F, Cl, Br, I, haloalkyl, —NH 2 ,

—NHR 23a , —N(R 23a ) 2 , —N 3 , —NO 2 , —CN, —CNO, —CNS, —C(═O)OR 23a , —C(═O)R 23a ,

—OC(═O)R 23a , —N(R 23a )C(═O)R 23a , —C(═O)N(R 23a ) 2 , ureido, —OR 23a , —SR 23a ,

—S(═O) 2 —(C 1 -C 6 alkyl), —S(═O) 2 -aryl, and —S(═O) 2 —N(R 23a ) 2 ;

R 23a is H or C 1 -C 6 alkyl;

alternatively, two R 23a may be combined, together with the N atom to which they are attached, to form a 5 to 7 membered heterocyclic group; and

r is 2, 3, 4, 5, 6, 7, 8, 9, or 10.

31. A compound of claim 1 having Formula (I):

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is C 1 -C 4 alkyl;

R 2 is —(CH 2 ) a CH 2 NHC(═NH)NH—Y, —(CH 2 ) c CH 2 NHCONH 2 , or —(CH 2 ) d CH(R 7 )NR 9 R 10 ;

a is 1, 2, or 3;

c is 1, 2, or 3;

d is 0 or 1;

R 7 is H or methyl;

R 9 is H or C 1 -C 10 alkyl;

R 10 is H, C 1 -C 10 alkyl, or an amino protecting group;

Y is H, CN, or NO 2 ;

Q is —B(OH) 2 , pinanediol boronic ester, bicyclohexyl-1,1′-diol boronic ester, or 1,2-dicyclohexyl-ethane-1,2-diol boronic ester;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, R A C(═O)—, R A SC(═O)—, or R A ;

R 20 is selected from the group consisting of:

—CN, halo, haloalkyl-, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,

—CO 2 H, —C(═O)CO 2 H, —C(═O)NH 2 , —C(═O)H, —S(═O)NH 2 , —S(═O) 2 NH 2 ,

—OH, —SH, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)NH 2 ,

—NHC(═O)R 20a , —NHC(═O)OR 20a , —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a ,

—S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a ,

—C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHR 20b , phthalimido,

—(O-alkyl) r , —O-alkyl-OH, —(O-alkyl) r -OH,

—OR 20c , —SR 20c , —S-alkyl-R 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c ,

—S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c ,

carbocyclyl optionally substituted with 1-5 R 21 ; and

heterocarbocyclyl optionally substituted with 1-5 R 21 ;

R 20a is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or alkynyl is optionally substituted by one or more halo, C 1 -C 4 alkyl, aryl, heteroaryl or —NHR 20b ;

R 20b is an amino protecting group;

R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21 is selected from the group consisting of:

C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkoxy,

C 1 -C 20 thialkoxy, —OH—CN, halo, haloalkyl, —NH 2 , —NH(alkyl), —N(alkyl) 2 ,

—NHC(═O)O-alkyl, —NHC(═O)alkyl, —C(═O)O-alkyl, —C(═O)alkyl,

—S(═O)-alkyl, —S(═O) 2 -alkyl, —S(═O)-aryl, —S(═O) 2 -aryl,

carbocyclyl optionally substituted with 1-5 R 22 , and

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 22 is selected from the group consisting of:

C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —; and

r is 2, 3, 4, or 5;

with the proviso that when X is R A C(═O)—, R A is a C 4 -C 15 straight-chained alkyl substituted with R 20 , and R 20 is —CN, —CO 2 H, —C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHC(═O)R 20a , —NHR 20b , carbocyclyl, or phthalimido; then R 2 is not —(CH 2 ) a CH 2 NHC(═NR 4 )NH—Y, wherein Y is H, —CN, or —NO 2 .

32. The compound of claim 31 wherein R 1 is 2-propyl.

33. The compound of claim 31 wherein Q is —B(OH) 2 .

34. The compound of claim 31 wherein Q is pinanediol boronic ester.

35. The compound of claim 31 wherein X is R A C(═O)—.

36. The compound of claim 31 wherein R 2 is —CH 2 NH—C(═O)OCH 2 (C 6 H 5 ).

37. A compound of claim 1 having Formula (I):

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 3 -C 7 cycloalkyl;

R 2 is —CH 2 NH 2 or —CH 2 NR 9 R 10 ;

R 9 is H or C 1 -C 10 alkyl;

R 10 is H, C 1 -C 10 alkyl, carbocyclyl, heterocarbocyclyl, C 1 -C 10 alkyl-C(═O)—, carbocyclyl-C(═O)—, heterocarbocyclyl-C(═O)—, carbocyclylalkyl-C(═O)—, heterocarbocyclylalkyl-C(═O)—, C 1 -C 10 alkyl-S(═O) 2 —, carbocyclyl-S(═O) 2 —, heterocarbocyclyl-S(═O) 2 —, carbocyclylalkyl-S(═O) 2 —,

heterocarbocyclylalkyl-S(═O) 2 —, C 1 -C 10 alkyl-NHC(═O)—,

carbocyclyl-NHC(═O)—, heterocarbocyclyl-NHC(═O)—,

carbocyclylalkyl-NHC(═O)—, heterocarbocyclylalkyl-NHC(═O)—,

C 1 -C 10 alkyl-OC(═O)—, carbocyclyl-OC(═O)—, heterocarbocyclyl-OC(═O)—, carbocyclylalkyl-OC(═O)—, heterocarbocyclylalkyl-OC(═O)—, or an amino protecting group; wherein R 10 is optionally substituted with 1, 2 or 3, R 23 ;

alternatively, R 9 and R 10 together with the N atom to which they are attached form a heterocarbocyclyl group;

Q is —B(OH) 2 , —B(OR 14 ) 2 , or a cyclic boronic ester wherein said cyclic boronic ester contains from 2 to 20 carbon atoms, and, optionally, a heteroatom which can be N, S, or O;

R 14 is H, C 1 -C 4 alkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, R A C(═O)—, R A SC(═O)—, or R A ;

R 20 is selected from the group consisting of:

—CN, halo, haloalkyl-, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,

—CO 2 H, —C(═O)CO 2 H, —C(═O)NH 2 , —C(═O)H, —S(═O)NH 2 , —S(═O) 2 NH 2 ,

—OH, —SH, —NH 2 , —NH(alkyl), —N(alkyl) 2 , —NHC(═O)NH 2 ,

—NHC(═O)R 20a , —NHC(═O)OR 20a , —OR 20a , —SR 20a , —S(═O)R 20a , —S(═O) 2 R 20a ,

—S(═O) 2 —NHR 20a , —SC(═O)R 20a , —C(═O)R 20a , —C(═O)NHR 20a ,

—C(═O)O—R 20a , —NHS(═O) 2 R 20a , —NHR 20b , phthalimido,

—(O-alkyl) r , —O-alkyl-OH, —(O-alkyl) r -OH,

—OR 20c , —SR 20c , —S(═O)—R 20c , —S(═O) 2 —R 20c ,

—S(═O) 2 —NHR 20c , —SC(═O)R 20c , —C(═O)R 20c , —C(═O)OR 20c , —C(═O)NHR 20c ,

carbocyclyl optionally substituted with 1-5 R 21 ; and

heterocarbocyclyl optionally substituted with 1-5 R 21 ;

R 20a is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, or C 2 -C 20 alkynyl; wherein said alkyl, alkenyl, or alkynyl is optionally substituted by one or more halo, C 1 -C 4 alkyl, aryl, heteroaryl or —NHR 20b ;

R 20b is an amino protecting group;

R 20c is carbocyclyl optionally substituted with 1-5 R 22 ; or

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 21 is selected from the group consisting of:

C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkoxy,

C 1 -C 20 thialkoxy, —OH—CN, halo, haloalkyl, —NH 2 , —NH(alkyl), —N(alkyl) 2 ,

—NHC(═O)O-alkyl, —NHC(═O)alkyl, —C(═O)O-alkyl, —C(═O)alkyl,

—S(═O)-alkyl, —S(═O) 2 -alkyl, —S(═O)-aryl, —S(═O) 2 -aryl,

carbocyclyl optionally substituted with 1-5 R 22 , and

heterocarbocyclyl optionally substituted with 1-5 R 22 ;

R 22 is selected from the group consisting of:

C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, phenyl,

halo, haloalkyl, alkoxy, thialkoxy, amino, alkylamino, dialkylamino,

carboxyl, alkyl-OC(═O)—, alkyl-C(═O)—, aryl-OC(═O)—,

alkyl-OC(═O)NH—, aryl-OC(═O)NH—, alkyl-C(═O)NH—, alkyl-C(═O)O—,

(alkyl-O) r -alkyl, HO-(alkyl-O) r -alkyl-, —OH, —SH, —CN, —N 3 , —CNO, —CNS,

alkyl-S(═O)—, alkyl-S(═O) 2 —, H 2 NS(═O)—, and H 2 NS(═O) 2 —;

R 23 is selected from the group consisting of:

C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, F, Cl, Br, I, haloalkyl, —NH 2 ,

—NHR 23a , —N(R 23a ) 2 , —N 3 , —NO 2 , —CN, —CNO, —CNS, —C(═O)OR 23a , —C(═O)R 23a ,

—OC(═O)R 23a , —N(R 23a )C(═O)R 23a , —C(═O)N(R 23a ) 2 , ureido, —OR 23a , —SR 23a ,

—S(═O) 2 —(C 1 -C 6 alkyl), —S(═O) 2 -aryl, and —S(═O) 2 —N(R 23a ) 2 ;

R 23a is H or C 1 -C 6 alkyl;

alternatively, two R 23a may be combined, together with the N atom to which they are attached, to form a 5 to 7 membered heterocyclic group; and

r is 2, 3, 4, or 5.

38. The compound of claim 37 wherein R 1 is 2-propyl.

39. The compound of claim 37 wherein Q is —B(OH) 2 .

40. The compound of claim 37 wherein Q is pinanediol boronic ester.

41. The compound of claim 37 wherein X is R A C(═O)—.

42. The compound of claim 37 wherein R 2 is —CH 2 NH—C(═O)OCH 2 (C 6 H 5 ).

43. A compound of claim 1 of Formula (I):

or pharmaceutically acceptable salt, stereoisomeric or tautomeric form thereof, wherein:

R 1 is 2-propyl;

R 2 is —CH 2 CH 2 CH 2 NHC(═NH)NH—NO 2 , —CH 2 CH 2 CH 2 NHC(═O)NH 2 , —CH(CH 3 )OH, —CH 2 CONH 2 , —CH 2 NH 2 , or —CH 2 NR 9 R 10 ;

R 9 is H;

R 10 is methyl-C(═O)—, ethyl-C(═O)—, propyl-C(═O)—, butyl-C(═O)—, pentyl-C(═O)—,

2-(ethoxycarbonyl)ethyl-C(═O)—, 4-methyl-phenyl-C(═O)—, cyclopropyl-C(═O)—,

4-fluoro-phenyl-C(═O)—, 4-H 2 NSO 2 -phenyl-C(═O)—, 4-H 3 CSO 2 -phenyl-C(═O)—,

4-phenyl-phenyl-C(═O)—, 3,4-dimethoxy-benzyl-C(═O)—, 3-pyridinyl-C(═O)—,

2-(hydroxy)-pyridin-3-yl-C(═O)—, 6-(morpholino)-pyridin-3-yl-C(═O)—,

2-(pyridin-4-yl)thiazol-4-yl-C(═O)—, 2-pyrazinyl-C(═O)—,

2,5-dimethyl-pyrazolyl-C(═O)—, N-methyl-2-pyrrolyl-C(═O)—,

2-pyrrolidinyl-C(═O)—, 2-thiophenyl-C(═O)—, 5-isoxazolyl-C(═O)—,

4-(tetrazol-5-yl)phenyl-C(═O)—, (5-tetrazolyl)CH 2 —C(═O)—,

N—H 3 CSO 2 -piperidinyl-C(═O)—, butyl-OC(═O)—, (benzyl)-OC(═O)—,

(9-fluorenylmethyl)-OC(═O)—, pentyl-NHC(═O)—, propyl-NHC(═O)—,

phenyl-NHC(═O)—, 4-methyl-phenyl-NHC(═O)—, methyl-S(═O) 2 —,

4-fluoro-phenyl-S(═O) 2 —, 4-cyano-phenyl-S(═O) 2 —,

1-methyl-imidazol-4-yl-S(═O) 2 —, 2-thiophenyl-S(═O) 2 —,

(4-methyl-phenyl)-NHC(═O)NH—S(═O) 2 —, and

(4-methyl-phenyl)-S(═O) 2 NHC(═O)—,

alternatively, R 9 and R 10 together with the N atom to which they are attached form pyrrolyl or pyrazolyl;

Q is —B(OH) 2 , pinanediol boronic ester, bicyclohexyl-1,1′-diol boronic ester, or 1,2-dicyclohexyl-ethane-1,2-diol boronic ester;

X is R A C(═O)—, R A NHC(═O)—, R A S(═O) 2 —, or R A C(═O)—;

R A is CH 3 —, C 2 H 5 —, C 3 H 7 —, C 4 H 9 —, C 5 H 11 —, C 6 H 13 —, C 7 H 15 —, C 8 H 17 —, C 9 H 19 —, C 10 H 21 —, C 11 H 23 —, C 12 H 25 —, C 13 H 27 —, adamantyl-, bicycloheptanyl-,

cyclopropyl substituted with 0-3 R 21 ;

cyclopentyl substituted with 0-2 R 21 ;

cyclohexyl substituted with 0-2 R 21 ;

pyrazinyl substituted with 0-1 R 21 ;

imidazolyl substituted with 0-1 R 21 ;

tetrahydrofuranyl substituted with 0-1 R 21 ;

oxothiazolidinyl substituted with 0-1 R 21 ;

thiazolyl substituted with 0-2 R 21 ;

furanyl substituted with 0-2 R 21 ;

pyrrolidinyl substituted with 0-1 R 21 ;

piperidinyl substituted with 0-1 R 21 ;

piperazinyl substituted with 0-1 R 21 ; or

pyridinyl substituted with 0-1 R 21 ;

R 20 is selected from the group consisting of:

hydroxy-, methoxy-, ethoxy-, propoxy-, butoxy-, pentoxy-, hexyloxy-, heptyloxy-, octyloxy-, methoxyethoxy-, methoxyethoxyethoxy-, methyl-S—, ethyl-S—, octyl-S—, methyl-C(═O)S—, (acetylamino)methyl-S—, amino-, methylamino-, dimethylamino-, methyl-C(═O)—, phenyl-C(═O)—, (H 3 CSO 2 )phenyl-C(═O)—, thiophenyl-C(═O)—, methyl-OC(═O)—, ethyl-OC(═O)—, butyl-OC(═O)NH—, methyl-C(═O)NH—, methoxyethoxy-methyl-C(═O)NH—, H 2 NC(═O)—, methyl-NHC(═O)—, ethyl-NHC(═O)—, propyl-NHC(═O)—, phenyl-NHC(═O)—, H 2 NC(═O)NH—, H 2 NS(═O) 2 —, octyl-S(═O) 2 —, phenyl-S(═O) 2 —, methylphenyl-S(═O) 2 —, thiophenyl-S(═O) 2 —, cyclopentyl-, cyclohexyl-, cycloheptyl-, adamantyl-, bicycloheptanyl-, cyclopentenyl-, phenyl-, methoxy-phenyl-, methyl-phenyl-, dimethyl-phenyl-, ethyl-phenyl-, propyl-phenyl-, butyl-phenyl-, fluoro-phenyl-, difluoro-phenyl-, chloro-phenyl-, bromo-phenyl-, iodo-phenyl-, dimethylamino-phenyl-, cyclohexyloxy-, 2-isopropyl-5-methyl-cyclohexyloxy-, naphthyl-, methoxynaphthyl-, naphthyloxy-, phenoxy-, (methyl-phenyl)oxy-, (ethyl-phenyl)oxy-, (propyl-phenyl)oxy-, (butyl-phenyl)oxy-, (fluoro-phenyl)oxy-, (chloro-phenyl)oxy-, (bromo-phenyl)oxy-, naphthyl-S—, benzyl-S—, (methyl-phenyl)methyl-S—, pyrimidinyl-S—, piperidinyl-, N-methyl-piperidinyl, N-propyl-piperidinyl-, phthalimido-, thiophenyl-, methyl-thiophenyl-, imidazolyl-, furanyl-, tetrazolyl-, oxopyrrolidinyl-, indolyl-, and methyl-indolyl-; and

R 21 is selected from the group consisting of:

methyl-, ethyl-, propyl-, butyl-, pentyl-, hexyl-, heptyl-, ethenyl-, propenyl-, butenyl-, methoxy-, ethoxy-, propoxy-, phenoxy-, fluoro-, chloro-, bromo-, methyl-C(═O)—, butyl-OC(═O)—, butyl-OC(═O)NH—, phenyl-, methoxyphenyl-, fluorophenyl-, chlorophenyl-, bromophenyl-, pyrrolyl-, and pyridinyl-.

44. A compound selected from:

Example

No

Compound Name

D.1.1

Naphthalen-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.1.2

2-Pyrazinecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]-

D.1.3

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.1.4

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.1.5

3-[(1,1-dimethylethoxy)carbonylamino]benzamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-

D.1.6

2-(2-methoxyethoxy) acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl

D.1.7

2-[2-(2-methoxyethoxy)ethoxy]acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl

D.1.8

(E)-3-(Ethoxycarbonyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.1.9

2-Piperidin-1-yl-acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.1.10

4-(1-Methyl-piperidin-4-yl)-butanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.1.11

2-Acetylamino-acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.2.1

4-(methoxycarbonyl)butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.2.2

4-(1-Butyl-piperidin-4-yl)-butanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.2.3

2-Butoxyacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.1

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.2

Naphthalen-1-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.3

2-Phenylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.4

1-Phenylcyclopentanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.5

(2R)-2-Phenylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.6

(2S)-2-Phenylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.7

Dodecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.8

Octanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.9

Acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.10

4-(1,1-Dimethylethyl)cyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.11

trans-4-Pentylcyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.12

4-Phenylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.13

2-(3-Methoxyphenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.14

4-(1,1-Dimethylethyl)benzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.15

Nonanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.16

(RS)-2-Cyclopentylhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.17

Thiophene-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.18

2,3-Difluorobenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.19

2-(2-Iodophenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl

D.3.20

Cyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.21

2-(4-Bromophenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.22

Benzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.23

2-Methylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.24

4-Bromobenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.25

(2S)-2-Phenylpropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.26

(E)-2-Methyl-3-phenyl-acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.27

2-[(Naphthalen-2-yl)oxy]acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.28

2,2-Dimethylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.29

2-(2-Chlorophenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.30

5-Methylthiophene-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.31

cis-3-(2-Methoxyphenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.32

(2-Methylphenoxy)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.33

2-(2,5-Dimethylphenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.34

trans-3-(2-Bromophenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.35

4-Isopropylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.36

4-(4-methylphenyl)butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.37

2-(2-Naphthylsulfanyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.38

5-Methylhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.39

3-Thiophen-2-yl-propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.40

2,4-Dimethylthiazole-5-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.41

Furan-3-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.42

(2R)-2-Phenylpropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.43

2-Cycloheptylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.44

1-Methylcyclopropanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.45

1-Methyl-cyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.46

2-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl]oxyacetamide, N-[(1S)-1-

[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.47

(E)-2-Butenamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.48

3-Methylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.49

3-Phenylpropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.50

4-(4-Methoxyphenyl)-butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.51

Thiophene-3-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.52

2-Thiophen-3-yl-acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl

D.3.53

(E)-Penta-2,4-dienoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.54

2-(4-Isopropylphenoxy)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.55

2-(4-Ethylphenoxy)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.56

(E)-2-Methylhex-2-enoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.57

3-(3-Methylphenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.58

2-Adamantan-1-ylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.59

(RS)-2-Cyclopent-2-enylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl

D.3.60

4-Diethylaminobenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.61

(RS)-2-Methylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.62

3-(4-Methylphenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.63

Hexa-2,4-dienoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.64

4-Pyrrol-1-yl-benzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.65

(E)-3-Thiophen-3-yl-acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.66

Hept-2-enamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.67

2-(3,4-Dimethylphenoxy)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.68

Dec-9-enamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.69

(E)-Undec-2-enoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.70

(E)-Dec-3-enoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.71

2,2-Dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxamide, N-[(1S)-1-

[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.72

2-Methylcyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.73

5-Cyclohexylpentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.74

3-Methoxycyclohexanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.75

(3R)-3,7-Dimethyl-oct-6-enoic acid amide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl

D.3.76

3-[(4-methylbenzyl)sulfanyl]propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.77

(3S)-3,7-Dimethyl-oct-6-enoic acid amide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.78

(RS)-4-Ethyloctanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.79

5-Fluoro-2-methoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.80

2-(4-Bromophenoxy)-acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.81

2-(1-Methyl-1H-indol-3-yl)acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.82

Hexahydro-2,5-methanopentalene-3a(1H)-carboxamide, N-[(1S)-1-[[[(1R)-

1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.83

Bicyclo[2.2.1]heptane-2-carboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.84

(RS)-2-(4-Chlorophenyl)propionamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.85

(2S)-2-methylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.86

(4RS)-1-[(1,1-dimethylethoxy)carbonyl]-piperidine-4-carboxamide, N-[(1S)-

1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.87

(RS)-4-Methyloctanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.88

2-Fluoro-5-methylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.89

2-(Bicyclo[2.2.1]hept-2-yl)acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.90

Cyclopropanecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.91

4-Ethoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.92

(E)-3-(4-Bromophenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.93

(2S)-2-(6-Methoxynaphthalen-2-yl)-propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.94

3-Fluoro-4-methoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.95

4-Fluoro-3-methylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.96

Non-2-enoic acid amide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.97

(E)-3-(Naphthalen-2-yl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.98

Quinoline-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.99

1-(4-Methoxyphenyl)-cyclopropanecarboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.101

3-Butenamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.102

Tetradecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.103

3-(1H-Indol-3-yl)-propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.104

4-Phenoxybutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.105

5-Oxo-5-phenyl-pentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.106

(2RS)-1-((1,1-dimethylethoxy)carbonyl)-piperidine-2-carboxamide, N-[(1S)-

1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.107

Pyridine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.108

Pyridine-3-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.109

Pyridine-4-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.110

(2S)-1-((1,1-dimethylethoxy)carbonyl)-piperidine-2-carboxamide, N-[(1S)-

1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.111

(2R)-1-((1,1-dimethylethoxy)carbonyl)-piperidine-2-carboxamide, N-[(1S)-

1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.112

3,3-Dimethyl-butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.113

4-[(Phenylamino)carbonyl]butanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.114

2,2-Dimethylpentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.115

5-Thiophen-2-yl-pentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.116

(3RS)-1-((1,1-dimethylethoxy)carbonyl)-piperidine-3-carboxamide, N-[(1S)-

1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.117

8-Phenyl-octanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl

D.3.118

3-[[(1,1-dimethylethoxy)carbonyl]amino]propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.119

Tridecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.120

Succinamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.121

Pentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.122

[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]butanamide, N-[(1S)-1-

[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.123

2-(Dimethylamino)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.124

5-(4-Fluorophenyl)-pentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.125

8-Oxo-8-phenyloctanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.126

4-(Thiophen-2-yl)butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.127

5-Oxo-5-(thiophen-2-yl)pentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.128

2-(3-Chlorophenyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.129

Undecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.130

4-Heptylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.131

6-Phenylhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.132

5-Phenylpentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.133

10-Hydroxydecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.134

5-Oxo-5-(4-phenylpiperazin-1-yl)pentanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.135

2-(1H-Tetrazol-5-yl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.136

2-(Tetrazol-1-yl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.137

2-(Pyrimidin-2-ylsulfanyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.138

3-Methylsulfanylpropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.139

3-(Naphthalen-2-ylsulfanyl)-propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.140

2-[(Phenylmethyl)sulfanyl]acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.141

6-Oxoheptanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.142

4-(4-Methanesulfonylphenyl)-4-oxobutanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.143

(2S)-1-Acetylpyrrolidine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.144

3-Hydroxy-2,2-dimethylpropanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.145

2-Ethylsulfanylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.146

3-Ureidopropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.147

3-Methoxypropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.148

2-Methylsulfanylacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.149

3H-Imidazole-4-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.150

7-Oxo-octanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.151

(E)-3-(Imidazol-4-yl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.152

(RS)-Tetrahydrofuran-3-carboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.153

(E)-3-(2-Methoxyphenyl)acrylamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.154

2-Ethoxyacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.155

-Furan-2-yl-propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.156

-(Benzenesulfonyl)propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.157

-Sulfamoylbutanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.158

(4S)-2-Oxo-1,3-thiazolidine-4-carboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.159

(2R)-1-Acetylpyrrolidine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.160

-[(Acetylamino)methylsulfanyl]-propanamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.161

-(Acetylsulfanyl)hexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.162

(Thiophene-2-sulfonyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.163

-(Acetylamino)butanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.164

(2Z)-3-(Propylaminocarbonyl)-2-propenamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.165

-(Octylsulfonyl)propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.166

-(Octylsulfanyl)propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.167

,2-Dimethylhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.168

-Hydroxyhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.169

-Oxopentanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.170

-Oxohexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.171

Benzothiazole-6-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.172

-(Octyloxy)propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.173

-(2-Oxo-pyrrolidin-1-yl)-acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.174

Benzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.175

-[2-(2-Methoxyethoxy)ethoxy]acetamide, N-[(1S,2R)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.176

-Phenylbutanamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.177

(4-Methylphenoxy)acetamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.178

Hexanamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.179

-Butylbenzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.180

Naphthalene-2-carboxamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.3.181

Hexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.182

-(4-Methylbenzenesulfonyl)acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]

D.3.183

Heptanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.184

1-(Carbamoyl)undecanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.185

-(Benzenesulfonyl)acetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.1

Naphthalene-1-sulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.2

Naphthalene-2-sulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.3

Decane-1-sulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.4

Octanesulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.5

Benzenesulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.5.1

(2S)-4-[[imino(nitroamino)methyl]amino]-2-[(2-naphthylmethyl)-amino]-

pentanamide, N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]

D.5.2

(2S)-4-[[imino(nitroamino)methyl]amino]-2-[(1-naphthylmethyl)-amino]-

pentanamide, N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]

D.5.3

(2S)-4-[[imino(nitroamino)methyl]amino]-2-[undecylamino]-pentanamide,

N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]

D.5.4

(2S)-4-[[imino(nitroamino)methyl]amino]-2-[(phenylmethyl)amino]-

pentanamide, N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]

D.6.1

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-(2-naphthyl) urea

D.6.2

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-phenyl urea

D.6.3

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-heptyl urea

D.6.4

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-(1-naphthyl) urea

D.6.5

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-undecylurea

D.6.6

N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-

hydroxypropyl]-N′-undecylurea

D.6.7

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-[5-(ethoxycarbonyl)pentyl] urea

D.7.1

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(2E)-

3-(2-methoxyphenyl)-1-oxoprop-2-enyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

D.7.2

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((E)-2-

methyl-3-phenylacryl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.3

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-(4-

methylphenyl)butanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.4

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[((2RS)-2-phenylpropanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.5

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-(4-

isopropylphenoxy)acetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.6

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-oxo-

5-phenylpentanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.7

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[[(4RS)-1-[(1,1-dimethylethoxy)carbonyl]piperidine-4-carbonyl]amino]-1-

oxopentyl]amino]-3-methylbutyl]

D.7.8

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

diethylaminobenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.9

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((E)-2-

methylhex-2-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.10

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(tiophen-3-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.11

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

isopropylbenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.12

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

methylthiophene-2-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.13

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(benzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.14

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((E)-2-

butenoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.15

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((E)-

penta-2,4-dienoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.16

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3,3-

dimethyl-butanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.17

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[5-

(2,5-dimethylphenoxy)-2,2-dimethylpentanoyl]amino]-1-oxopentyl]amino]-

3-methylbutyl]

D.7.18

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2,2-

dimethylpentanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.19

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-

(thiophen-2-yl)butanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.20

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[5-(4-

fluorophenyl)pentanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.21

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2,2-

dimethylhexanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.22

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(hex-

2,4-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.23

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-

(thiophen-2-yl)propenoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.24

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

cyclohexylpentanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.25

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((3R)-

3,7-dimethyloct-6-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.26

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-[(4-

methylbenzyl)sulfanyl]propanoyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

D.7.27

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

pyrrol-1-ylbenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.28

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

fluoro-2-methoxybenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.29

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((2S)-

2-methylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.30

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(cyclopropanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.31

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

ethoxybenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.32

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((E)-3-

(4-bromophenyl)prop-2-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.33

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(2S)-

2-(6-methoxynaphthalen-2-yl)-propanoyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

D.7.34

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[1-(4-

methoxyphenyl)-cyclopropanecarbonyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

D.7.35

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

fluoro-4-methoxybenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.36

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(E)-3-

(naphthalen-2-yl)prop-2-enoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.37

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

fluoro-3-methylbenzyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.38

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[[[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]butanoyl]amino]-1-

oxopentyl]amino]-3-methylbutyl]

D.7.39

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

bromobenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.40

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

butenoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.41

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(undecanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.42

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-

(acetylamino)butanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.43

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(6-

phenylhexanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

D.7.44

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

phenylpentanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

D.7.45

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

methoxypropanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

D.7.46

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2,2-

dimethyl-3-(2-methylpropenyl)-cyclopropanecarbonyl]amino]-1-

oxopentyl]amino]-3-methylbutyl]-

D.7.47

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

methoxycyclohexanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

D.7.48

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-

(1H-indol-3-yl)-propanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]-

D.7.49

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((RS)-

2-cyclopent-2-enyl-acetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.50

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

thiophen-2-yl-pentanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.51

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(6-oxo-

heptanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.52

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(7-oxo-

octanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.53

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(hexanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.54

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(heptanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.55

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

octyloxy-propanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.56

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(benzothiazol-6-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.57

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(undec-2-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.58

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(9-

decenoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.7.59

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(tetradecanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

D.8

Decanamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]-

D.8.1

(2S)-2-[(Benzyloxycarbonyl)amino]-4-methylpentanamide, N-[(1S,2R)-1-

[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-hydroxypropyl]-

D.8.2

10-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-decanoic-amide-N-[(1S),(2R)-2-

hydroxy, 1-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl] aminocarbonyl]-

propyl]-

D.9

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(4-methylbenzoyl)amino]ethyl]-

D.10

2-S-decanoylamino-3-(hexanoylamino)-propionamide, N-[(1S)-1-[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]

D.11

2-S-decanoylamino-3-(4-fluorosulfonylamino)propionamide, N-[(1S)-1-

[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]

D.12

2-S-decanoylamino-3-(3,4-dimethoxyphenylacetamido)propionamide, N-

[(1S)-1-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-

1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]

D.13

2-S-decanoylamino-3-(phenylureido)propionamide, N-[(1S)-1-[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]

D.14

2-Aminoacetamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl],

Hydrochloride salt

D.15

3-Aminopropanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl];

hydrochloride salt

D.15.1

(4RS)-piperidine-4-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl],

HCl salt

D.15.2

(RS)-Piperidine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl];

HCl salt

D.15.3

(2S)-Piperidine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl];

HCl salt

D.15.4

(2R)-Piperidine-2-carboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl];

HCl salt

D.16.1

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(acetamido)ethyl]-

D.16.2

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(9-fluorenylmethyloxycarbamoyl)ethyl]-

D.16.3

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(pentyl-ureido)ethyl]-

D.16.4

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(methanesolfonamido)ethyl]-

D.16.5

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(ethoxycarbonyl-succinyl]-amide)ethyl]-

E.1.1

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((2E)-

3-ethoxycarbonyl-1-oxoprop-2-enyl)amino]-1-oxopentyl]amino]-3-

methylbutyl]

E.1.2

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

pyrazinecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.3

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

butylbenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.4

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

naphthoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.5

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxopropylamino]-1-

oxopentyl]amino]-3-methylbutyl]

E.1.6

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(2-

methoxyethoxy)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl], HCl salt

E.1.7

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

butoxyacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.8

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-[2-

(2-methoxyethoxy)ethoxy]acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.9

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(acetylamino)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl], HCl salt

E.1.10

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-

(methoxycarbonyl)butanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.11

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

(naphthalen-2-yloxy)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.12

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

thiophen-2-yl-propanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.13

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[2-(2-

chlorophenyl)acetyl]amino]-3-methylbutyl]HCl salt

E.1.14

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(1-oxo-

4-(1-butylpiperidin-4-yl)butyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.1.15

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(1-

octanesulfonyl)amino]-1-oxopentyl]amino]-3-methylbutyl], HCl salt

E.1.16

Boronic acid, [(1R)-1-[[(2S)-3-[(4-methylbenzoyl)amino]-2-

[(decanoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.1.17

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(decanoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.1.18

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[[10-(1,3-dioxo-1,3-dihydro-

isoindol-2-yl)-decanoyl]amino]-1-oxobutyl]amino]-3-methylbutyl]

E.2.1

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(1-

oxodecyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.2

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(octanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.3

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(1-

phenylcyclopentanecarbnyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.4

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((2R)-

2-phenylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.5

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-

(1,1-Dimethylethyl)cyclohexanecarbonyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

E.2.6

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(trans-

4-pentylcyclohexanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.7

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

phenylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.8

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

(1,1-dimethylethyl)benzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.9

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(nonanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.10

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

thiophenecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.11

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2,3-

difluorobenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.12

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(dodecanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.13

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(2-

iodophenyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.14

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(cyclohexanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.15

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

methylbenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.16

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((2S)-

2-phenylpropanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.17

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2,2-

dimethylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.18

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(quinoline-2-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.19

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(non-2-

enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.20

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

methylcyclohexanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.21

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(hept-

2-enoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.22

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(3,4-dimethylphenoxy)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.23

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((RS)-

4-ethyloctanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.24

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(hexahydro-2,5-methanopentalene-3a(1H)-carbonyl)amino]-1-

oxopentyl]amino]-3-methylbutyl]

E.2.25

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(bicyclo[2.2.1]heptane-2-carbonyl)amino]-1-oxopentyl]amino]-3-

methylbutyl]

E.2.26

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

methylhexanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.27

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2,4-

dimethylthiazole-5-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.28

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(furan-

3-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.29

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

cycloheptylacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.30

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(1-

methylcyclopropanecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.31

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

methylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.32

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

phenylpropanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.33

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(E)-3-

(3-methylphenyl)acryl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.34

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

adamantan-1-ylacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.35

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((RS)-

2-methylbutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.36

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

phenylacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.37

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(4-

methoxyphenyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.38

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(4-

bromophenyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.39

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((RS)-

4-methyloctanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.40

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

fluoro-5-methylbenzoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.41

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(bicyclo [2.2.1]hept-2-yl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.42

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(4-

phenoxybutanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.43

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

pyridinecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.44

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

pyridinecarbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.45

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(tridecanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.46

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(8-

phenyloctanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.47

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-(4-

methanesulfonylphenyl)-4-oxobutanoyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

E.2.48

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-

(naphthalen-2-ylsulfanyl)-propanoyl]amino]-1-oxopentyl]amino]-3-

methylbutyl]

E.2.49

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

[(phenylmethyl)sulfanyl]acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.50

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(3-

Methylsulfanylpropanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.51

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[((2S)-

1-acetylpyrrolidine-2-carbonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.52

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[trans-

3-(2-bromophenyl)acryl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.53

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(tetrazol-1-yl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.54

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(pyrimidin-2-ylsulfanyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.55

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(4-

ethylphenoxy)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.56

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(2,5-dimethylphenyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.57

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(8-oxo-

8-phenyloctanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.58

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(2-

naphthylsulfanyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.59

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(RS)-

2-cyclopentylhexanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.60

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-(4-

methylphenyl)acryl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.61

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[4-(4-

methoxyphenyl)-butanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.62

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

thiophen-3-yl-acetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.63

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-

(dimethylamino)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.64

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[5-oxo-

5-(thiophen-3-yl)pentanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.65

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(acetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.66

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

ethylsulfanylacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.67

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(10-

hydroxydecanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.68

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(2-

methylsulfanylacetyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.69

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[[(thiophene-2-sulfonyl)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.70

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-

(benzenesulfonyl)propanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.71

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(RS)-

tetrahydrofuran-3-carbonyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.72

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(naphthalene-1-sulfonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

E.2.73

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(naphthalene-2-sulfonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

E.2.74

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-

[(benzenesulfonyl)amino]-1-oxopentyl]amino]-3-methylbutyl]-

F.1

Decanamide, N-[(1S)-1-[[[(1R)-1-[(4R,5R)-4,5-dicyclohexyl-

[1,3,2]dioxaborolan-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-

F.2

4-Phenylbutanamide, N-[(1S)-1-[[[(1R)-1-[13,15-dioxa-14-bora-

dispiro[5.0.5.3]-pentadec-14-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]-amino]butyl]-

or a pharmaceutically acceptable salt, free base, or boronic ester thereof.

45. A compound selected from:

Example No

Compound Name

D.2.6

2-[2-(2-methoxyethoxy)acetylamino]acetamide, N-[(1S)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl

D.2.7

Decanamide, N-[1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-

4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]methyl]

D.2.8

2-[2-(2-methoxyethoxy)ethoxy]acetamide, N-[1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]methyl]

D.2.9

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-5-ureidopentyl]-

D.2.10

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-5-ureidopentyl]-

D.3.190

3-[4-(2-Propyl)phenyl]propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.191

3-[4-(Ethyl)phenyl]propanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.3.192

6-hydroxyhexanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.6

4-Butoxyenzenesulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.7

4-Butyl-benzenesulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.4.8

4-Pentyl-benzenesulfonamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-4-[[imino(nitroamino)methyl]amino]butyl]

D.6.8

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-(4-butylphenyl) urea

D.6.9

N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-

methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-4-

[[imino(nitroamino)methyl]amino]butyl]-N′-(4-heptyloxylphenyl) urea

D.8.3

4-(Pyridin-3-yl)benzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.4

2-Pyrazinecarbossamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.5

Tridecanamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.6

4-Phenylbenzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.7

2,2-Dimethydecanamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.8

(4-phenoxy)benzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.9

5-Butyl-2-pyridinecarboxamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.10

4-propoxybenzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.11

3-(3-Pyridyl)benzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.12

6-Phenyl-2-pyridinecarboxamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.13

3-propoxybenzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.14

1-Bromonaphthalene-2-carboxamide, N-[(1S,2R)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-hydroxypropyl]

D.8.15

6-Bromonaphthalene-2-carboxamide, N-[(1S,2R)-1-[[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-hydroxypropyl].

D.8.16

3-Phenylbenzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl].

D.8.17

4-(2-Fluorophenyl)benzamide, N-[(1S,2R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-

hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-hydroxypropyl].

D.8.18

2-Pyrazinecarboxamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-carbamoylethyl]

D.8.19

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-carbamoylethyl]

D.8.20

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-carbamoylethyl]

D.16.6

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(benzyloxycarbonylamide)ethyl]-

D.16.7

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(1H-pyrazol)ethyl]-

D.16.8

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(benzyloxycarbonylamide)ethyl]-

D.16.9

4-Phenoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(benzyloxycarbonylamide)ethyl]-

D.17

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(aminoethyl)-hydrochloride salt

D.18

2-S-(4-Butylbenzoylamino)-3-(2-pyrazinocarbonylamino)-N-[(1S)-1-[[(1R)-1-

[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-

benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]

D.19

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[4-fluoro-benzenesulfonammide]ethyl]-

D.20

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(2,5-dimethyl-2H-

pyrazole)carbonylamino]ethyl]-

D.21

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(4-methylphenyluriedosulfonylamino)ethyl]-

D.22

4-Phenoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(3-phenyl-ureido)ethyl]-

D.23

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(4-methylphenylsulfonylureido)ethyl]-

D.24.1

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[4-fluoro-benzenesulfonammide]ethyl]-

D.24.2

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(4-sulfonamidophenyl)carbonylamido]ethyl]-

D.24.3

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(acetamido)ethyl]-

D.24.4

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(methanesulfonamido)ethyl]-

D.24.5

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(propylureido)ethyl]-

D.24.6

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(4-methylphenyl)carbonylamino]ethyl]

D.24.7

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(1,1-dimethylethoxycarbonyl)amino]ethyl]-

D.24.8

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(thien-2-ylcarbonyl)amino]ethyl]-

D.24.9

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(thien-2-ylcarbonyl)amino]ethyl]-

D.24.10

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(hexanonylamino)ethyl]-

D.24.11

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano,1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(cyclopropancarbonylamino)ethyl]-

D.24.12

4-Butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(3-phenyl-ureido)ethyl]-

D.24.13

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(N-methyl-2-pyrrolylcarbonylamide)ethyl]-

D.24.14

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano,1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(3,4-dimethoxyphenyl)acetylamino]ethyl]-

D.24.15

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(nicotinonylamino)ethyl]-

D.24.16

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano,1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(4-sulfonylamino)benzoylamino]ethyl]-

D.24.17

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano,1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(1H-tertazol-5-yl-acetylamino]ethyl]-

D.24.18

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(4-

methysulfonylphenyl)carbonylamino]ethyl]-

D.24.19

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(nicotinonylamino)ethyl]-

D.24.20

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(4-(2H-tetrazol-5-

yl)phenyl)carbonylamino]ethyl]-

D.24.21

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(1-isoxazol-5-yl)-carbonylamino]ethyl]-

D.24.22

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(4-cyanophenyl)sulfonylamino]ethyl]-

D.24.23

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(1-methyl-1H-imidazole-4-)sulfonylamino]ethyl]-

D.24.24

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(2-thiophene)sulfonylamino]ethyl]-

D.24.25

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(6-morpholin-4-nicotinoylamino)ethyl]-

D.24.26

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(2-pyridin-4-thiazolecarbonylamino)ethyl]-

D.24.27

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(4-methylphenyluriedosulfonylamino)ethyl]-

D.24.28

4-phenoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(benzyloxycarbonylamide)ethyl]-

D.24.29

4-phenoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[4-fluoro-benzenesulfonammide]ethyl]-

D.24.30

4-phenoxybenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-[(2,5-dimethyl-2H-pyrazole)carbonylamino]ethyl]-

D.24.31

4-phenoxybenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-

3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(4-phenylbenzoylamino)ethyl]-

D.24.32

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(4-phenylbenzoylamino)ethyl]-

D.24.33

4-butylbenzamide,N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(3-phenylpropynoylamino)ethyl]-

D.24.34

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(2-hydroxy-3-nicotinoylamino)ethyl]-

D.24.35

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(D-piroglutamoylamino)ethyl]-

D.24.36

4-butylbenzamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(1-methanesulfonyl-piperidine-4-

carbonylamino)ethyl]-

D.24.37

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-(3-phenyl-ureido)ethyl]-

D.24.38

Decanamide, N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-(acetamido)ethyl]-

D.25.1

Decanamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-amino]ethyl]-hydrochloride salt

D.25.2

Decanamide,N-[(1S)-1-[[[(1R)-1-[(3aS,aS,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl-]-3-

methylbutyl]amino]carbonyl]-2-amino]ethyl]-hydrochloride salt

D.26

4-Butylbenzamide, N-[(1R)-1-[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-

trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-

methylbutyl]amino]carbonyl]-2-[(4-methylbenzoyl)amino]ethyl]-

E.1.23

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(4-phenylbutanoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.1.24

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(undecylaminocarbonyl)amino]-

1-oxobutyl]amino]-3-methylbutyl]

E.1.25

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(1-Bromo-2-naphthoyl)amino]-

1-oxobutyl]amino]-3-methylbutyl]

E.1.26

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-Bromo-2-naphthoyl)amino]-

1-oxobutyl]amino]-3-methylbutyl]

E.1.27

Boronic acid, [(1R)-1-[[(2S)-3-carbamoyl-2-[(decanoyl)amino]-1-

oxopropyl]amino]-3-methylbutyl]

E.1.28

Boronic acid, [(1R)-1-[[(2S)-3-carbamoyl-2-[4-butyl(benzoyl)amino]-1-

oxopropyl]amino]-3-methylbutyl]

E.1.29

Boronic acid, [(1R)-1-[[(2S)-2-[(decanoyl)amino]-1-oxo-5-ureido-

pentyl]amino]-3-methylbutyl]

E.1.30

Boronic acid, [(1R)-1-[[(2S)-2-[(4-butylbenzoyl)amino]-1-oxo-5-ureido-

pentyl]amino]-3-methylbutyl]

E.2.76

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(RS)-2-

(4-chlorophenyl)propanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.77

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[2-(4-

bromophenoxy)acetyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.78

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[3-(4-

ethylphenyl)propanoyl]amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.79

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[3-[4-

(heptyloxy)phenyl]-ureido]-1-oxopentyl]amino]-3-methylbutyl]

E.2.80

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[(5-

oxohexanoyl)amino]-1-oxopentyl]amino]-3-methylbutyl]

E.2.81

Boronic acid, [(1R)-1-[[(2S)-5-[[imino(nitroamino)methyl]amino]-2-[[(2RS)-

1-[(1,1-dimethylethoxy)carbonyl]piperidine-2-carbonyl]amino]-1-

oxopentyl]amino]-3-methylbutyl]

E.3.1

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(2-naphthoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.2

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(p-tolyloxyacetamide]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.3

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(tridecanoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.4

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(naphthalene-2-

sulfonyl)amino]-1-oxobutyl]amino]-3-methylbutyl]

E.3.5

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(4-phenylbenzoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.6

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(2,2dimethyl-decanoyl)amino]-

1-oxobutyl]amino]-3-methylbutyl]

E.3.7

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(4-Phenoxybenzoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.8

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[[4-(1-

propoxy)butylbenzoyl]amino]-1-oxobutyl]amino]-3-methylbutyl]

E.3.9

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(3-pyridin-3-yl-

benzoyl)amino]-1-oxobutyl]amino]-3-methylbutyl], hydrochloride salt

E.3.10

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(3-propoxy-benzoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.11

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(3-phenylbenzoyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.3.12

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(4-(2-

fluorophenyl)benzoyl)amino]-1-oxobutyl]amino]-3-methylbutyl]

E.4

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[[4-(3-pyridyl)benzoyl]amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.4.1

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(2-pyrazinecarbonyl)amino]-1-

oxobutyl]amino]-3-methylbutyl]

E.4.2

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(5-butyl-pyridine-2-

carbonyl)amino]-1-oxobutyl]amino]-3-methylbutyl]

E.4.3

Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenyl-pyridine-2-

carbonyl)amino]-1-oxobutyl]amino]-3-methylbutyl]

E.5

Boronic acid, [(1R)-1-[[(2S)-3-(2-pyrazincarbonylamino)-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.1

Boronic acid, [(1R)-1-[[(2S)-3-(acetylamino)-2-[(decanoylamino)]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.2

Boronic acid, [(1R)-1-[[(2S)-3-(propylureido)-2-[(4-butyl)-benzoylamino]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.3

Boronic acid, [(1R)-1-[[(2S)-3-(methanesulfamido)-2-[(4-butyl)-

benzoylamino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.4

Boronic acid, [(1R)-1-[[(2S)-3-[2-(1H-pyrazol)ethyl]-2-[(4-butyl)-

benzoylamino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.5

Boronic acid, [(1R)-1-[[(2S)-3-(methanesulfamido)-2-[(4-butyl)-

benzoylamino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.6

Boronic acid, [(1R)-1-[[(2S)-3-[(carbobenzyloxyamino]-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.7

Boronic acid, [(1R)-1-[[(2S)-3-[(thien-2-ylcarbonyl)amino]-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.8

Boronic acid, [(1R)-1-[[(2S)-3-(acetylamino)-2-[4-butyl-benzoylamino)]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.9

Boronic acid, [(1R)-1-[[(2S)-3-[(thien-2-ylcarbonyl)amino)]-2-

[(decanoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.10

Boronic acid, [(1R)-1-[[(2S)-3-(hexanoylamino)-2-[(4-butylbenzoylamino)]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.11

Boronic acid, [(1R)-1-[[(2S)-3-[4-fluoro-benzenesulfonamide]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.12

Boronic acid, [(1R)-1-[[(2S)-3-[4-fluoro-benzenesulfonamide]-2-

[(decanoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.13

Boronic acid, [(1R)-1-[[(2S)-3-(hexanonylamino)-2-[(decanoylamino)]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.14

Boronic acid, [(1R)-1-[[(2S)-3-(hexanonylamino)-2-[(cyclopropancarbonylamino)]-

1-oxopropyl]amino]-3-methylbutyl]3-

methylbutyl]amino]carbonyl]-2-(cyclopropancarbonylamino)ethyl]-

E.5.15

Boronic acid, [(1R)-1-[[(2S)-3-[(3,4-dimethoxyphenyl)acetylamino]-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.16

Boronic acid, [(1R)-1-[[(2S)-3-[1-N-methyl-2-pyrrolylcarbonylamino]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.17

Boronic acid, [(1R)-1-[[(2S)-3-[4-sulfamylbenzoylamino]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.18

Boronic acid, [(1R)-1-[[(2S)-3-(nicotinoylamino)-2-[(4-butylbenzoylamino)]-

1-oxopropyl]amino]-3-methylbutyl]

E.5.19

Boronic acid, [(1R)-1-[[(2S)-3-(3-phenylureido)-2-(4-butylbenzoylamino)-1-

oxopropyl]amino]-3-methylbutyl]

E.5.20

Boronic acid, [(1R)-1-[[(2S)-3-[(4-methylsulfonyl)benzoylamino]-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.21

Boronic acid, [(1R)-1-[[(2S)-3-(3-phenylureido)-2-(decanoylamino)-1-

oxopropyl]amino]-3-methylbutyl]

E.5.22

Boronic acid, [(1R)-1-[[(2S)-3-(nicotinoylamino)-2-(decanoylamino)-1-

oxopropyl]amino]-3-methylbutyl]

E.5.23

Boronic acid, [(1R)-1-[[(2R)-3-(4-methylphenylcarbonyl)-2-(decanoylamino)-

1-oxopropyl]amino]-3-methylbutyl]

E.5.24

Boronic acid, [(1R)-1-[[(2S)-3-[4-(1H-tetrazolyl)-phenylcarbonylamino]-2-

[(4-butylbenzoylamino)]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.25

Boronic acid, [(1R)-1-[[(2S)-3-(2-isoxazolylcarbonylamino)-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.26

Boronic acid, [(1R)-1-[[(2S)-3-[1-methyl-1H-imidazole-4-sulfamoyl]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.27

Boronic acid, [(1R)-1-[[(2S)-3-[6-morpholin-4-yl-pyridine-3-sulfamoyl]-2-

[(4-butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl] hydrochloride

E.5.28

Boronic acid, [(1R)-1-[[(2S)-3-(6-morpholinonicotinamide]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.29

Boronic acid, [(1R)-1-[[(2S)-3-(4-(1,3-dimethyl-1H-pyrazole-5-

carbonylamino]-2-[(4-butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl] hydrochloride

E.5.30

Boronic acid, [(1R)-1-[[(2S)-3-[4-fluoro-benzenesulfonamide]-2-[(4-

phenoxybenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl]

E.5.31

Boronic acid, [(1R)-1-[[(2S)-3-(4-(1,3-dimethyl-1H-pyrazole-5-

carbonylamino]-2-[(4-phenoxybenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]carbonylamino]ethyl]-

E.5.32

Boronic acid, [(1R)-1-[[(2S)-3-(4-phenylureido]-2-[(4-

phenoxybenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.33

Boronic acid, [(1R)-1-[[(2S)-3-(4-phenybenzamide]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.34

Boronic acid, [(1R)-1-[[(2S)-3-(4-phenylbenzamide]-2-[(4-

phenoxybenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.35

Boronic acid, [(1R)-1-[[(2S)-3-(phenylpropionamide]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.36

Boronic acid, [(1R)-1-[[(2S)-3-(4-methylphenylsulfonyl)-ureido]-2-[(4-

butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.37

Boronic acid, [(1R)-1-[[(2S)-3-(4-(2-(4-pyridyl)-1,3-thiazole-4-

carbonylamino)]-2-[(4-butylbenzoyl)amino]-1-oxopropyl]amino]-

3-methylbutyl]

E.5.38

Boronic acid, [(1R)-1-[[(2S)-3-(1-methanesulfonylpiperidine-4-

carbonylamino)-2-[(4-butylbenzoylamino)]-1-

oxopropyl]amino]-3-methylbutyl]

E.5.39

Boronic acid, [(1R)-1-[[(2S)-3-[(2-thiophene)sulfonylamino]-2-[(4-

butylbenzoylamino)]-1-oxopropyl]amino]-3-methylbutyl]

E.5.40

Boronic acid, [(1R)-1-[[(2S)-3-(4-(1H-1,2,4-triazol-1-yl)benzoylamide)]-2-

[(4-butylbenzoyl)amino]-1-oxopropyl]amino]-3-methylbutyl] hydrochloride

E.5.41

Boronic acid, [(1R)-1-[[(2R)-3-(4-methylphenylcarbonyl)-2-(decanoylamino)-

1-oxopropyl]amino]-3-methylbutyl]

E.5.42

Boronic acid, [(1R)-1-[[(2S)-3-(4-phenylureido]-2-(decanoylamino)-1-

oxopropyl]amino]-3-methylbutyl]

E.5.43

Boronic acid, [(1R)-1-[[(2S)-3-acetylamino-2-decanoylamino-1-

oxopropyl]amino]-

3-methylbutyl]

F.2.1

4-Butylbenzamide, N-[(1S,2R)-1-[[[(1R)-1-[13,15-dioxa-14-bora-

dispiro[5.0.5.3]pentadec-14-yl]-3-methylbutyl]amino]carbonyl]-2-

hydroxypropyl]-

or a pharmaceutically acceptable salt, free base, or boronic ester thereof.

46. The compound of claim 1 , wherein the compound is boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenyl-pyridine-2-carbonyl)amino]-1-oxobutyl]amino]-3-methylbutyl], or a pharmaceutically acceptable salt or boronic ester thereof.

47. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.

48. A pharmaceutical composition comprising a compound according to claim 24 and a pharmaceutically acceptable carrier.

49. A pharmaceutical composition comprising a compound according to claim 30 and a pharmaceutically acceptable carrier.

50. A pharmaceutical composition comprising a compound according to claim 31 and a pharmaceutically acceptable carrier.

51. A pharmaceutical composition comprising a compound according to claim 37 and a pharmaceutically acceptable carrier.

52. A pharmaceutical composition comprising a compound according to claim 43 and a pharmaceutically acceptable carrier.

53. A pharmaceutical composition comprising a compound according to claim 44 and a pharmaceutically acceptable carrier.

54. A pharmaceutical composition comprising a compound according to claim 45 and a pharmaceutically acceptable carrier.

55. A pharmaceutical composition comprising a compound according to claim 46 and a pharmaceutically acceptable carrier.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2022
From: MILLENNIUM PHARMACEUTICALS, INC.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 061725/0893 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2015
From: TEVA PHARMACEUTICALS
To: MILLENNIUM PHARMACEUTICALS, INC.
Reel/Frame 037267/0401 →
Continuity (3)
Division 10918664 · Aug 12, 2004
Provisional Application 60495764 · Aug 14, 2003
Related Publication 20090291918A1 · Nov 26, 2009