IP Library › Granted Patent US 8,785,381
Granted Patent B2
US 8,785,381 · App. 12/497,373 · Granted Jul 22, 2014

Oral GLP-1 formulations

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Quick Facts
Patent No.
US 8,785,381
App. No.
12/497,373
Granted
Jul 22, 2014
Kind
B2
Abstract

The present invention provides pharmaceutical compositions comprising of at least one delivery agent and GLP-1. These pharmaceutical compositions facilitate the oral delivery of GLP-1, providing improved (e.g. increased) bioavailability of GLP-1 compared to administration of GLP-1 without a delivery agent.

Claims (7)

1. A formulation comprising (i) a glucagon-like 1 peptide (GLP-1) compound having the amino acid sequence of SEQ ID NO: 2 and (ii) a delivery agent selected from the group consisting of

and pharmaceutically acceptable salts thereof.

2. The formulation of claim 1 , further comprising an excipient selected from pharmaceutically acceptable buffers, suspending agents, co-solvents, preservatives, isotonicity agents, and combinations thereof.

3. The formulation of claim 1 , in the form of a tablet, capsule or particle.

4. The formulation of claim 1 , wherein the GLP-1 compound is a GLP-1 analog.

5. The formulation of claim 1 , wherein the GLP-1 compound is a GLP-1 derivative.

6. The formulation of claim 1 , wherein the GLP-1 compound is a GLP-1 fragment.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2021
From: EMISPHERE TECHNOLOGIES, INC.
To: NOVO NORDISK NORTH AMERICA OPERATIONS A/S
Reel/Frame 056750/0169 →
CHANGE OF ADDRESS Recorded May 5, 2014
From: EMISPHERE TECHNOLOGIES, INC.
To: EMISPHERE TECHNOLOGIES, INC.
Reel/Frame 032837/0457 →