NAPHTHOQUINONE COMPOSITIONS WITH ANTI-AGING, ANTI-INFLAMMATORY AND SKIN EVEN-TONING PROPERTIES
The present invention relates to methods and compositions comprising naphthoquinones such as 2,3-dimethylnaphthalene-1,4-dione, for the use of treating, regulating or preventing a skin condition characterized by oxidative stress or a degenerative process. Methods of preventing, lightening or reducing the appearance of visible and/or tactile discontinuities of the skin resulting from skin pigmentation or skin aging are also disclosed.
1 . A cosmetic or dermatological composition comprising one or more naphthoquinones of formula I or their reduced form of formula Ia:
wherein
n is 0 to 4;
R 1 and R 2 are independently selected from (C 1 -C 8 )alkyl or (C 1 -C 4 )alkoxy;
each R 3 is independently hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, halogen, or (C 1 -C 6 ) haloalkyl;
and mixtures thereof.
2 . The composition of claim 1 , wherein n is 0.
3 . A cosmetic or dermatological composition comprising a therapeutically effective amount of the composition of claim 1 and a pharmaceutically, dermatologically, or cosmetically acceptable carrier.
4 . The cosmetic or dermatological composition of claim 1 , comprising 2,3-dimethylnaphthalene-1,4-dione of formula Ib, its reduced form 2,3-dimethylnaphthalene-1,4-diol of formula Ic, or a mixture thereof:
5 . The cosmetic or dermatological composition of claim 4 , comprising 2,3-dimethylnaphthalene-1,4-dione (formula Ib).
6 . The cosmetic or dermatological composition of claim 4 , comprising 2,3-dimethylnaphthalene-1,4-diol (formula Ic).
7 . A cosmetic composition comprising a therapeutically effective amount of the composition of claim 4 and a pharmaceutically or cosmetically acceptable carrier.
8 . A method of regulating or preventing a skin condition wherein the skin condition is characterized by oxidative stress or a degenerative process, comprising administering to a subject exhibiting said skin condition an effective amount of the composition of claim 1 .
9 . A method of reducing, treating, or preventing the signs of skin aging or of reducing the appearance of signs of skin aging comprising administering to a subject exhibiting said skin condition an effective amount of the composition of claim 1 .
10 . A method of regulating or preventing a skin condition wherein the skin condition is associated with visible and/or tactile discontinuities of the skin, comprising administering to a subject exhibiting said skin condition, an effective amount of the composition of claim 1 .
11 . The method of claim 10 , wherein the visible and /or tactile discontinuities are associated with aging, age-related damage or damage resulting from extrinsic factors.
12 . The method of claim 10 , wherein the visible discontinuities of the skin are associated with pigmentation disorders.
13 . The method of claim 12 , wherein the pigmentation disorders are selected from uneven pigmentation, hyperpigmentation, age spots, vitiligo, and melasma.
14 . A method for preventing, lightening or reducing the appearance of visible and/or tactile discontinuities of the skin comprising administering to a subject exhibiting said skin conditions an effective amount of the composition of claim 1 .
15 . The method of claim 14 , where the visible and/or tactile discontinuities of the skin are selected from the group consisting of increased pore size, flaking, mottling, wrinkles, furrows, and skin lines.
16 . A method for preventing, lightening or reducing the appearance of visible discontinuities of the skin, comprising administering to a subject exhibiting said skin conditions an effective amount of the composition of claim 1 .
17 . The method of claim 16 , wherein the visible discontinuities of the skin are selected from the group consisting of uneven pigmentation, hyperpigmentation, age spots, vitiligo and melasma.
18 . A method of regulating or preventing a skin condition wherein the skin condition is associated with visible and/or tactile discontinuities of the skin, while concurrently reducing, treating, or preventing the signs of skin aging, comprising administering to a subject exhibiting said skin condition, an effective amount of the composition of claim 1 .
19 . The method of claim 18 , wherein the visible discontinuities of the skin are selected from uneven pigmentation, hyperpigmentation, age spots, vitiligo and melasma.
20 . The method of claim 18 , wherein the visible discontinuities of the skin are a result from harmful ultraviolet radiation, pollution and other environmental insults, stress and fatigue.
21 . Use of a composition comprising a skin care composition of claim 1 in the manufacture of a cosmetic or dermatological composition for treating a mammalian subject of a dermatologic condition to prevent, regulate or treat signs of skin aging or skin pigmentation, or to reduce the appearance of skin aging or skin pigmentation.