Electrical stimulation treatment of hypotension
View Patent ↗Methods and devices for treating hypotension, such as in cases of shock, including septic shock and anaphylactic shock, wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from hypotension to block and/or modulate nerve signals that regulate blood pressure.
1. A method of treating a patient with a disorder comprising:
positioning an electrode at a target region comprising parasympathetic nerves within or on the patient; and applying at least one electrical impulse to the electrode such that increased blood pressure is achieved in the patient, wherein the electrical impulse has a frequency of between about 10 to 50 Hz.
2. The method of claim 1 wherein the frequency is between about 15 to 30 Hz.
3. The method of claim 1 wherein the frequency is about 25 Hz.
4. The method of claim 1 wherein the electrical impulse has an amplitude of between about 0.2 volts to 20 volts.
5. The method of claim 1 wherein the electrical impulse has a pulsed-on time of between about 200-400 microseconds.
6. The method of claim 1 wherein the electrical impulse has a pulsed-on time of about 200 microseconds.
7. The method set forth in claim 1 wherein the target region comprises a region of the parasympathetic nervous system.
8. The method of claim 1 wherein the target region comprises a region of the vagus nerve proximal to the cardiac branch of the vagus nerve.
9. The method set forth in claim 1 wherein increased blood pressure is achieved by at least one of:
increasing heart function; and controlling vasoconstriction.
10. The method set forth in claim 9 wherein increasing heart function includes increasing blood pressure and maintaining a stable heart rate.
11. The method of claim 1 wherein the disorder is hypotension.
12. The method of claim 11 wherein the disorder is hypotension associated with shock.
13. A method of treating a patient with a disorder comprising:
positioning an electrode at a target region comprising parasympathetic nerves within or on the patient; and
applying at least one electrical impulse to the electrode to a target region in the patient such that increased blood pressure is achieved in the patient without a substantial change in heart rate.
14. The method of claim 13 wherein the target region comprises a region of the parasympathetic nervous system, the electrical impulse being sufficient to modulate one or more nerves within the region.
15. The method of claim 13 wherein the electrical impulse has a frequency of between about 15 Hz to 25 Hz, an amplitude of between about 0.2 to 20 volts and a pulsed-on time of between about 200 to 400 microseconds.
16. The method of claim 14 wherein the electrical impulse is sufficient to inhibit an activity of the region of the parasympathetic nervous system.
17. The method of claim 14 wherein the electrical impulse is sufficient to stimulate an activity of the region of the parasympathetic nervous system.
18. The method of claim 13 wherein the disorder is hypotension.
19. The method of claim 13 wherein the disorder is hypotension associated with shock.
20. A device for the treatment of a patient with a disorder comprising:
an electrical impulse generator;
one or more electrodes coupled to the electrical impulse generator; and
wherein the electrical impulse generator is configured for generation of an electrical impulse having a frequency of about 10 to 50 Hz and suitable for increasing blood pressure when the electrical impulse is applied to a target region comprising parasympathetic nerves in the patient.
21. The device of claim 20 wherein the frequency is between about 15 to 30 Hz.
22. The device of claim 20 wherein the frequency is about 25 Hz.
23. The device of claim 20 wherein the electrical impulse has an amplitude of between about 0.2 to 20 volts.
24. The device of claim 20 wherein the electrical impulse has an amplitude of between about 1 volt to 1.5 volts.
25. The device of claim 20 wherein the electrical impulse has a pulsed-on time of between about 200-400 microseconds.
26. The device of claim 20 wherein the electrical impulse has a pulsed-on time of about 200 microseconds.
27. The device of claim 20 wherein the target region comprises a region of the parasympathetic nervous system.
28. The device of claim 27 wherein the target region comprises a region of the vagus nerve proximal to the cardiac branch of the vagus nerve.
29. The device of claim 20 wherein the electrical impulse is sufficient to increase blood pressure and maintain a stable heart rate.
30. The device of claim 20 wherein the disorder is hypotension.
31. The device of claim 20 wherein the disorder is hypotension associated with shock.
32. The device of claim 27 wherein the electrical impulse is sufficient to inhibit an activity of the region of the parasympathetic nervous system.
33. The device of claim 27 wherein the electrical impulse is sufficient to stimulate an activity of the region of the parasympathetic nervous system.