Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
View Patent ↗Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.
1. A method for treating cancer selected from metastatic breast cancer, lung cancer, pancreatic cancer, ovarian cancer, prostate cancer, colon cancer, and small cell lung cancer, which comprises administering to a mammal a combination therapy comprising a dosage unit of Compound (1), having the formula,
or a stereoisomer of Compound (1), and a dosage unit of bevacizumab, wherein the combination therapy will provide a greater anti-cancer effect than the effect obtainable with either the dosage unit of Compound (1) or bevacizumab alone.
2. The method of claim 1 wherein the cancer is refractory, resistant, or sensitive to taxane treatment.
3. The method of claim 1 , wherein bevacizumab is administered following the administration of Compound (1).
4. The method according to claim 1 , wherein bevacizumab is administered before the administration of Compound (1).
5. The method according to claim 1 , wherein bevacizumab is administered substantially simultaneously with the administration of Compound (1).