Dynamic detection device based on surface plasmon resonance effect
A detection device based on the surface plasmon resonance effect, including a radiation emitter and a radiation detector, a fluidic substrate, a liquid crystal layer and respective control mechanism.
1. A dynamic detection device based on the Surface Plasmon Resonance effect, comprising:
(i) a radiation emitter and a radiation detector;
(ii) a fluidic substrate, placed between the radiation emitter and the radiation detector, containing channels and at least one detection zone, in which a detection surface is built in such a way that it enables the surface plasmon resonance effect to occur;
(iii) a liquid crystal layer, placed in between the radiation emitter and the radiation detector, capable of exhibiting at least two states of orientation, in order to modify at least one of incident radiation on the detector surface and outgoing radiation from the detection surface; and
(iv) a controlling means adapted to apply an external voltage with frequencies between 1 KHz and 100 KHz and voltages between 0 Volt and 50 Volts,
wherein the control means is further adapted to: change an average orientation of a plurality of liquid crystal molecules of the liquid crystal layer; change an equivalent focal length of the liquid crystal layer; set the liquid crystal layer for one of convergence or divergence of electromagnetic radiation; and dynamically adjust radiation properties of the liquid crystal layer;
wherein the liquid crystal layer is a nematic or twisted nematic liquid crystal layer, and
wherein the dynamic detection device enables a determination of chemical and/or biological events through the surface plasmon resonance effect occurring in a close proximity of the detection surface of the detection zone.
2. The dynamic detection device of claim 1 , wherein the control means applying an external electrical voltage to the liquid crystal layer produces the following behaviors:
(i) a uniform change in a thickness of the liquid crystal layer;
(ii) a uniform change in an orientation of the liquid crystal molecules in a proximity of borders of the liquid crystal layer; and
(iii) a uniform change in an anchoring strength of the liquid crystal molecules in the proximity of the borders of the liquid crystal layer.