Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system

1. A medicament delivery device, comprising:

a housing configured for ingestion by a patient and comprising a first part and a second part secured to the first part, an inner surface of the first part and an inner surface of the second part defining an interior volume of the housing; a flexible wall having an outer periphery, wherein:

the flexible wall is secured between the first part and the second part proximate the outer periphery such that, proximate the outer periphery, the flexible wall is fixed relative to the first part and the second part, the flexible wall separates the interior volume of the housing into a first compartment defined by the first part of the housing and the flexible wall and a second compartment defined by the second part of the housing and the flexible wall, and the flexible wall seals the first compartment of the interior volume relative to the second compartment of the interior volume; a reservoir disposed in the first compartment of the interior volume of the housing; a piston disposed in the second compartment of the interior volume of the housing; and

a driving mechanism disposed in the second compartment of the interior volume of the housing, configured to press the piston against the flexible wall to cause the substance to be released from the reservoir through an opening into a gastrointestinal tract of the patient.

2. The medicament delivery device according to claim 1 , wherein the first part of the housing comprises one of a protrusion or a recess and the second part of the housing comprises the other of the protrusion and the recess, in which the flexible wall is clamped in between the first part of the housing and the second part of the housing by insertion of the protrusion into the recess thereby securing the first part of the housing to the second part of the housing.

3. The medicament delivery device according to claim 1 , wherein the driving mechanism comprises a threaded component mounted on an electric motor, and the piston is driven by the threaded component of the driving mechanism.

4. The medicament delivery device according to claim 1 , wherein a part of a surface of the piston that contacts the flexible wall during release of the substance from the reservoir comprises a low friction material.

5. A capsule for introduction into a bodily lumen comprising:

a medicament delivery device according to claim 1 ; and

electronic circuitry to control the piston.

6. In vivo medicament delivery or diagnostic system comprising:

a capsule according to claim 5 ; and an external device arranged to communicate with the electronic circuitry in the capsule.

7. A medicament delivery device for delivering a substance inside a body, the device comprising:

a housing configured as an elongate capsule comprising a sidewall formed about a longitudinal axis, the sidewall having a diameter smaller than a length measured along the longitudinal axis of the capsule, the capsule adapted for complete insertion into a user's body and defining a dispensing hole, the housing comprising a first part and a

second part secured to the first part, the first part comprising a first portion of the sidewall and the second part comprising a second portion of the sidewall; a flexible wall secured between the first portion of the sidewall and the second portion of the sidewall proximate an outer periphery of the flexible wall such that the outer periphery of the flexible wall is fixed relative to the first part and the second part, the

flexible wall extending across the entirety of an inner diameter of the housing to separate the housing into a first compartment and a second compartment and forming a seal between the first compartment and the second compartment, the first compartment comprising a reservoir formed by a portion of the housing including the dispensing hole and the flexible wall; and

a driving mechanism disposed in the second compartment to displace the flexible wall toward the first compartment, causing at least a portion of the substance to be released from the reservoir through the dispensing hole, wherein the driving mechanism comprises an actuatable piston adapted to press against the flexible wall.

8. The device according to claim 7 , wherein the driving mechanism comprises a stepper motor and a screw mechanism, the stepper motor being configured to drive the piston to press against the flexible wall via the screw mechanism.

9. The device according to claim 7 , wherein the driving mechanism comprises a linear motor configured to directly drive the piston to press against the flexible wall.

10. The device according to claim 7 , wherein the piston has no sealing function with respect to the reservoir.

11. The device according to claim 7 , wherein the first part comprises one of a protrusion or a recess and the second part comprises the other of the protrusion or the recess wherein the recess is configured to receive the protrusion to secure the first part to the second part, and wherein the flexible wall is damped between the protrusion and the recess.

12. A capsule for delivering a substance inside a body, the capsule comprising:

a housing comprising a first part and a second part secured to the first part, the housing comprising a sidewall extending between opposite ends defining an internal volume and configured as a generally elongate capsule for complete insertion into a bodily lumen, the elongate capsule having a length along a longitudinal axis greater than a diameter of the capsule, normal the longitudinal axis, and the internal volume having an internal circumference normal to the longitudinal axis;

a flexible wall in the housing having an outer circumference conforming to the internal circumference of the internal volume of the housing, the flexible wall being secured, proximate the outer circumference, between the first part of the housing and the second part of the housing at the sidewall such that the flexible wall is fixed relative to the first part and the second, part proximate the sidewall, the flexible wail completely partitioning the internal volume of the capsule into a first compartment comprising a reservoir on a first side of the flexible wall, along the longitudinal axis, and a second compartment on a second side of the flexible wall, along the longitudinal axis, and the flexible wall sealing the first compartment relative to the second compartment; a driving mechanism disposed in the second compartment and configured to press against the flexible wall, causing the flexible wall to displace in a direction toward the reservoir to reduce a volume of the reservoir; control circuitry disposed in the second compartment and configured to operate the driving mechanism, and

a power source disposed in the second compartment fbr providing power to at least one of the control circuitry and the driving mechanism.

13. The medicament delivery device of claim 7 , wherein the housing is configured as an ingestible capsule.

14. The capsule of claim 12 , wherein the housing is configured as an ingestible capsule.

15. The medicament delivery device of claim 1 , wherein the piston is not sealed relative to a sidewall of the capsule.

16. The capsule of claim 12 , wherein the driving mechanism comprises an actuatable piston.

17. A method comprising:

causing a patient to ingest the medicament delivery device of claim 1 .