Composition for repelling and deterring vermin
View Patent ↗The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I), as defined herein before. Furthermore, it describes the corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of the formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defense against vermin. Thus, the invention describes how and in which form the compounds of the formula (I) or their acid addition salts are used to deter vermin from materials, places or warm-blooded animals.
1. A process for deterring vermin from warm-blooded animals other than human, said process comprising: applying topically, together with a spreading additive, to the skin, the pelt or the plumage of a warm-blooded animal other than human in need of defense against vermin, a compound of formula I
or their acid addition salts, wherein
R1 is hydrogen, halogen, NH 2 , OH, C 1 -C 3 -alkyl or C 1 -C 3 -alkoxy;
m is 1, 2 or 3;
R2 is hydrogen, halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 -alkyl, C 2 -C 20 -alkenylalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl
R3 is
R4 is hydrogen, C 1 -C 20 -alkyl, benzyl, or —C(O)—R8;
n is 0 or 1;
R5, R6 and R7 are each independently of each other hydrogen, halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 -alkyl, halo-C 1 -C 20 -alkyl, C 2 -C 20 -alkenylalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl; and
R8 is C 1 -C 20 -alkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, or benzyl.
2. The process according to claim 1 , whereby the compound of formula I is a compound of the formula Ie or one of its acid addition salts
wherein R1, R2, R4 and m have the meanings specified for formula I in claim 1 .
3. The process according to claim 2 , wherein R1 is hydrogen or halogen; m is 1 or 2; R2 is hydrogen, C 1 -C 3 -alkyl, or phenyl; R4 is hydrogen or acetyl;
R5 is hydrogen, R6 is hydrogen or phenyl; and R7 is hydrogen; C 1 -C 3 -alkyl or benzyl.
4. The process according to claim 1 , wherein the active ingredient employed is acetic acid 2-dibenzylamino-ethyl ester or an acid addition salt thereof.
5. The process according to claim 1 , wherein the compound of formula I is applied in the form of a pour-on or spot-on formulation.
6. A process for deterring vermin from places or materials where they are not wanted, said process comprising: applying an effective amount of a compound of formula I according to claim 1 to the place or to the material, at which one would like to deter insect pests, tics or mites.
7. A composition for repelling vermin, comprising a compound of formula I
or their acid addition salts, wherein
or their acid addition salts, wherein
R1 is hydrogen halogen, NH 2 , OH, C 1 -C 3 -alkyl or C 1 -C 3 -alkoxy;
m is 1, 2 or 3.
R2 is hydrogen halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 -alkyl, halo-C 1 -C 20 -alkyl, C 2 -C 20 -alkenylalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl
R3 is
R4 is hydrogen C 1 -C 20 -alkyl, benzyl, or —C(O)—R8; wherein when R4 is H, then R2 cannot be H, and when R2 is H, R4 cannot be H;
n is 0 or 1;
R5, R6 and R7 are each independently of each other hydrogen, halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 -alkyl, halo-C 1 -C 20 -alyl, C 2 -C 20 -alkenylalkyl, C 2 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl; and
R8 is C 1 -C 20 -alkoxy, unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, or benzyl;
and a spreading additive.
8. A process for the preparation of a composition for repelling vermin, whereby a compound of formula I according to claim 7 is mixed with a spreading additive.