Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties
The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods for screening for metallo-oxidoreductase inhibitors, and methods of treating an oxidoreductase related disorder by administering a metallo-oxidoreductase inhibitor to a subject in need of treatment thereof.
1. The lanosterol demethylase inhibitor, wherein the inhibitor is:
2. A pharmaceutical composition comprising a pharmaceutical carrier and the inhibitor of claim 1 , or salt thereof.
3. A method of treating a fungal disorder comprising administering a composition of claim 2 or salt thereof to a patient in need thereof, wherein said disorder is caused by a Candida species.
4. The method of claim 3 , wherein said Candida species is Candida albicans.