INHIBITORS OF AKT ACTIVITY

1 . (canceled)

2 . (canceled)

3 . (canceled)

4 . A compound according to Formula C:

wherein:

a is 0 or 1; b is 0 or 1; m is 0, 1 or 2; p is 0, 1 or 2;

R 2 is selected from: (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, CO 2 H, halo, OH and NH 2 ;

Ring X is a 3-7 membered cycloalkyl or 4-7 membered heterocyclyl optionally substituted with one to three R 3 ;

Ring Y is 4-7 membered cycloalkyl or a 5-7 membered heterocyclyl optionally substituted with one to three R 4 ;

R 1 is selected from: H, oxo, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, (C═O) a O b (C 2 -C 10 )alkenyl, (C═O) a O b (C 2 -C 10 )alkynyl, CO 2 H, halo, OH, O b (C 1 -C 6 )perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b (C 3 -C 8 )cycloalkyl, S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl and (C═O) a O b -heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 3 is independently selected from: (C 1 -C 6 )alkyl, CO 2 H, halo, OH, (C 1 -C 6 )alkoxy, (C 2 -C 10 )alkenyl;

R 4 is independently selected from: (C 1 -C 6 )alkyl, CO 2 H, halo, OH, (C 1 -C 6 )alkoxy, (C 2 -C 10 )alkenyl;

R 6 is: (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b C 1 -C 6 perfluoroalkyl, O a (C═O) b NR 7 R 8 , oxo, CHO, (N═O)R 7 R 8 , S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl or (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6a ;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , SH, oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C C 6 )alkylene-aryl, (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(R b ) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O a (C═O)b(C 1 -C 6 )alkyl, oxo, and N(R b ) 2 ;

R 7 and R 8 are independently selected from: H, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b (C 3 -C 8 )cycloalkyl, (C═O) a O b -aryl, (C═O) a O b -heterocyclyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, SH, SO 2 Ra, and (C═O) a NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 6a , or R 7 and R 8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocylcic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 6a ;

R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is independently: H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O) a O b (C 1 -C 6 )alkyl, or S(O) m R a ;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

5 . A compound according to Formula D:

wherein:

a is 0 or 1; b is 0 or 1; m is 0, 1 or 2;p is 0, 1 or 2 ;

R 2 is selected from: (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, CO 2 H, halo, OH and NH 2 ;

R 1 is selected from: H, oxo, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, (C═O) a O b (C 2 -C 10 )alkenyl, (C═O) a O b (C 2 -C 10 )alkynyl, CO 2 H, halo, OH, O b (C 1 -C 6 )perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b (C 3 -C 8 )cycloalkyl, S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl and (C═O) a O b -heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 6 is: (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b C 1 -C 6 perfluoroalkyl, O a (C═O) b NR 7 R 8 , oxo, CHO, (N═O)R 7 R 8 , S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl or (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6a ;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , SH, oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C 6 )alkylene-aryl, (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(R b ) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O a (C═O) b (C 1 -C 6 )alkyl, oxo, and N(R b ) 2 ;

R 7 and R 8 are independently selected from: H, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b (C 3 -C 8 )cycloalkyl, (C═O) a O b -aryl, (C═O) a O b -heterocyclyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, SH, SO 2 R a , and (C═O) a NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 6a , or R 7 and R 8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocylcic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 6a ;

R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is independently: H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O) a O b (C 1 -C 6 )alkyl, or S(O) m R a ;

or a pharmaceutically acceptable salt or stereoisomer thereof.

6 . A compound according to Formula E:

wherein:

a is 0 or 1; b is 0 or 1; m is 0, 1 or 2;

R 1 is selected from: H, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b aryl, OH, O b (C 1 -C 6 )perfluoroalkyl, (C═O) a O b (C 3 -C 8 )cycloalkyl, and (C═O) a O b -heterocyclyl, said alkyl, aryl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 6 is: (C═O) a O b C 10 -C 10 alkyl, (C═O) a O b aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b C 1 -C 6 perfluoroalkyl, O a (C═O) b NR 7 R 8 , oxo, CHO, (N═O)R 7 R 8 , S(O) m NR 7 R 8 , SH, S(O) m -(C 1 -C 10 )alkyl or (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6a ;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , SH, oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C 6 )alkylene-aryl, (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(R b ) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O a (C═O) b (C 1 -C 6 )alkyl, oxo, and N(R b ) 2 ;

R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is independently: H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O) a O b (C 1 -C 6 )alkyl, or S(O) m R a ;

or a pharmaceutically acceptable salt or stereoisomer thereof.

7 . A compound according to claim 4 which is selected from:

2-{4-[3-(1-methyl-1H-imidazol-4-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-methyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-ethyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-isopropyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-cyclopropyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-pyrimidin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[9-phenyl-3-(1,3-thiazol-4-yl)[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-ol;

2-{4-[3-(2-furyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

3-{8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}phenol;

methyl 6-{8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}pyridine-2-carboxylate;

2-[4-(9-phenyl-3-pyridin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[3-(1H-indol-5-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-isoxazol-3-yl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-pyrazin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

1-{8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}ethanol;

2-[4-(9-phenyl-3-pyridin-3-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-cyclobutyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[3-(cyclopropylmethyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-propyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(3-cyclopent-3-en-1-yl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-piperidin-2-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[3-(4-methyl-1,3-thiazol-5-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

2-[4-(9-phenyl-3-pyridin-4-yl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[9-phenyl-3-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

2-{4-[3-(1-benzyl-1H-indol-3-yl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8yl]phenyl}-5,8-dioxaspiro[3.4]octan-2-amine;

1-{8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}-2-methylpropan-2-ol;

2-[4-(3-tert-butyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

8-[4-(2-Amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-N-ethyl-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-amine; and

N′-{8-[4-(2-amino-5,8-dioxaspiro[3.4]oct-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}-N,N-dimethylpropane-1,3-diamine;

or a pharmaceutically acceptable salt or stereoisomer thereof.

8 . (canceled)

9 . (canceled)

10 . (canceled)

11 . (canceled)

12 . A pharmaceutical composition comprising a pharmaceutical carrier, and dispersed therein, a therapeutically effective amount of a compound of claim 4 .

13 . (canceled)