HYDROBROMIDE SALT OF AN ANTI-HIV COMPOUND
Solid dispersions and dosage forms comprising the hydrobromide salt of a diarylpyrimidine derivative, useful as an anti-HIV agent.
1 . A solid dispersion comprising a compound of formula (I):
in a water-soluble polymer.
2 . The solid dispersion of claim 1 , wherein the water-soluble polymer is selected from hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, copolyvidone, and vitamin E TGPS.
3 . The solid dispersion of claim 4 , wherein the polymer is hydroxypropylmethyl cellulose 2910 5 cps
4 . The solid dispersion of claim 3 , wherein the ratio of the polymer to pharmaceutical agent is in the range from 9:1 to 1:1.
5 . The solid dispersion of claim 6 , wherein the ratio of polymer to pharmaceutical agent is in the range from 3:1 to 1:1.
6 . A dosage form comprising the compound of claim 1 or claim 2 or the solid dispersion of claim 3 .
7 . The dosage form of claim 9 , wherein the dosage form is selected from a tablet or a capsule.
8 . A compound of formula (I):
9 . The compound of claim 1 having a degree of crystallinity of about 10% or less, or of about 5% or less, or of about 1% or less.
10 . A pharmaceutical composition comprising a compound of formula (I) as defined in claim 8 and a carrier.