V3 ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF CHRONIC PAIN

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Patent No.: US None
App. No.: 12/518,940

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Abstract

The present invention relates to a V 3 antagonist for use in the treatment of chronic pain, in particular neuropathic pain.

Claims (31)

1 - 3 . (canceled)

4 . A method of treatment of chronic pain comprising administering a pharmaceutically effective amount of a V 3 antagonist to a subject in need thereof.

5 . The method of treatment according to claim 4 , wherein the V 3 antagonist is selected from:

(2S,4R)-1-[5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide;

2-[2-(3-Chloro-4-fluorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide;

N-Isopropyl-2-[2-(3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]acetamide;

2-[2-(4-Fluoro-3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide;

2-[2-(3-Chlorophenyl)-6-[3-(4-hydroxypiperidin-1-yl)propoxy]-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide;

2-[2-(3-Chlorophenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)-4H-quinazolin-3-yl]-N-isopropylacetamide;

(S)-(+)-2-[2-(3-Chlorophenyl)-6-(2-methyl-3-pyrrolidin-1-ylpropoxy)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide;

2-[6-(5-Dimethylaminomethyl-2-fluorophenyl)-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide;

2-[6-(3-Dimethylaminomethylphenyl)-2-(4, fluoro-3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide;

N-tert-Butyl-2-[2-(3-chlorophenyl)-4-oxo-6-(3-pyrrolidin-1-ylpropoxy)-4H-quinazolin-3-yl]acetamide and

2-[6-(3-Dimethylaminomethylphenyl)-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide

or a pharmaceutically acceptable salt or solvate thereof.

6 . The method of treatment according to claim 4 , wherein the chronic pain is neuropathic pain.

7 . The method of treatment according to claim 4 , wherein the chronic pain is inflammatory pain.

8 . The method of treatment according to claim 4 , wherein the subject is a mammal.

9 . The method of treatment according to claim 8 , wherein the mammal is human.

10 . A pharmaceutical composition comprising a V 3 antagonist selected from (2S,4R)-1-[5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide;