Treatment of lung cancer
Disclosed are methods of treating lung cancer by administering to a human in need thereof effective amounts of FTS, or various analogs thereof, or a pharmaceutically acceptable salt thereof, optionally, in combination with a chemotherapeutic agent. Chemotherapeutic agents, and combinations thereof, for use with FTS, its analogs, or its salts are also disclosed.
1. A method of treating a human afflicted with lung cancer, comprising administering to the human an effective amount of FTS or an analog thereof as represented by the formula:
wherein
R 1 represents farnesyl or geranyl-geranyl;
R 2 represents the groups COOR 7 , CONR 7 R 8 , wherein R 7 and R 8 are each independently hydrogen, alkyl or alkenyl, and COOM wherein
M is a cation;
R 3 , R 4 , R 5 and R 6 are each independently hydrogen, alkyl, alkenyl, alkoxy, halo, trifluoromethyl, trifluoromethoxy, or alkylmercapto; and
X represents S; or a pharmaceutically acceptable salt thereof,
and
a chemotherapeutic agent selected from the group consisting of gemcitabine.
2. The method of claim 1 , wherein the human afflicted with lung cancer is administered FTS.
3. The method of claim 1 , wherein FTS or its analog or a pharmaceutically acceptable salt thereof is administered orally.
4. The method of claim 1 , wherein the chemotherapeutic agent is administered intravenously.
5. The method of claim 1 , wherein the chemotherapeutic agent is gemcitabine.