Natural polypeptides for oral health care
View Patent ↗The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Statherin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.
1. A composition for inhibiting bacterial growth in the oral cavity comprising a fusion protein comprising:
i. a lysine form of a Lactoferrin polypeptide and
ii. a Statherin polypeptide.
2. The composition of claim 1 , wherein the fusion protein is substantially purified.
3. The composition of claim 1 , wherein the composition further comprises an ingredient selected from a pharmaceutically acceptable excipient, a surfactant or surfactant-like molecule, an antibacterial agent, an antimicrobial agent, an antifungal agent or combinations thereof.
4. The composition of claim 3 , wherein the surfactant is sodium lauryl sulfate.
5. The composition of claim 1 , wherein the fusion protein further comprises an additional a second polypeptide.
6. The composition of claim 1 , wherein the fusion protein has SEQ ID NO: 10; SEQ ID NO: 11; or SEQ ID NO: 13.
7. A fusion protein having SEQ ID NO: 10, SEQ ID NO: 11, or SEQ ID NO: 13.
8. A method for inhibiting bacteria in the oral cavity comprising administering an effective amount of a composition comprising a fusion protein comprising:
i. a lysine form of a Lactoferrin polypeptide and
ii. a Statherin polypeptide to a patient in need thereof.
9. The method of claim 8 , wherein the fusion protein is substantially purified.
10. The method of claim 8 , wherein the composition further comprises an ingredient selected from a pharmaceutically acceptable excipient, a surfactant or surfactant-like molecule, an antibacterial agent, an antimicrobial agent, an antifungal agent or combinations thereof.
11. The method of claim 8 , further comprising administering an effective amount of the surfactant or surfactant-like molecule to allow the composition to penetrate biofilm.
12. The method of any claim 8 , wherein the fusion protein further comprises a second polypeptide.
13. A method for the treatment or prevention of an oral health condition comprising administering an effective amount of a composition comprising a fusion protein comprising:
i. a lysine form of a Lactoferrin polypeptide and
ii. a Statherin to a patient in need thereof.
14. The method of claim 13 , wherein the oral health condition is selected from dental caries, periodontal disease, dental plaque and inflammation of the oral cavity.
15. The method of claim 13 , wherein the fusion protein is substantially purified.
16. The method of claim 13 , wherein the composition further comprises an ingredient selected from a pharmaceutically acceptable excipient, a surfactant or surfactant-like molecule, an antibacterial agent, an antimicrobial agent, an antifungal agent or combinations thereof.
17. The method of claim 13 , further comprising administering an effective amount of a surfactant or surfactant-like molecule to allow the composition to penetrate biofilm.
18. The method of claim 13 , wherein the fusion protein further comprises a second polypeptide.