Polypeptides for inducing a protective immune response against
View Patent ↗The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.
1. A purified polypeptide immunogen comprising an amino acid sequence at least 99% identical to SEQ ID NO: 1, wherein said polypeptide provides protective immunity against S. epidermidis and the polypeptide does not comprise the amino acid sequence provided by SEQ ID NOs: 3 or 4.
2. The polypeptide of claim 1 ,
wherein said polypeptide consists essentially of SEQ ID NO: 1.
3. The polypeptide of claim 2 , wherein said polypeptide consists of the an amino acid sequence of SEQ ID NO: 1 or methionine-SEQ ID NO: 1.
4. A composition able to induce a protective immune response in a patient comprising an immunologically effective amount of the immunogen of claim 1 and a pharmaceutically acceptable carrier.
5. The composition of claim 4 , wherein said composition further comprises an adjuvant.