In-body power source having high surface area electrode
View Patent ↗Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.
1. A device comprising:
a solid support comprising a circuitry element;
a first electrode present on a surface of the solid support and coupled to the circuitry element, wherein the first electrode comprises a first active electrode material present on a porous under-layer, wherein the porous under-layer is selected to provide a surface area enhancement to the first electrode; and
a second electrode present on a surface of the solid support and coupled to the circuitry element, wherein the second electrode is electrically isolated from the first electrode and comprises a second active electrode material that is different from the first active electrode material;
wherein the first and second active electrode materials provide a voltage potential difference to the circuitry element via completion of a battery when the first and second materials contact an electrically conductive fluid within a body; and
wherein upon application of the voltage potential to the circuitry element, the circuitry element is configured to generate a conductively transmitted signal that employs the body as a conduction medium such that the signal is conducted between the circuitry element and a receiver through the body tissues.
2. The device according to claim 1 , wherein the device is dimensioned to be ingestible.
3. The device according to claim 2 , wherein the porous under-layer comprises a conductive material.
4. The device according to claim 3 , wherein the porous under-layer comprises an element selected from the group consisting of: Au, Cu, Pt, Ir, Pd, Rh and Ru and alloys thereof.
5. The device according to claim 3 , wherein the porous under-layer comprises an element selected from the group consisting of: Ti and Wand alloys thereof.
6. The device according to claim 3 , wherein the porous under-layer has a thickness ranging from 0.1 to 100 μm.
7. The device according to claim 1 , wherein the first electrode is present on the same surface of the solid support as the second electrode.
8. The device according to claim 1 , wherein the first and second electrodes are present on opposite surfaces of the solid support.
9. The device according to claim 1 , wherein the device comprises a pharmaceutically acceptable carrier composition.
10. The device according to claim 9 , wherein the pharmaceutically acceptable carrier composition is a tablet.
11. The device according to claim 9 , wherein the pharmaceutically acceptable carrier composition is a capsule.
12. The device according to claim 9 , wherein the pharmaceutically acceptable carrier composition comprises an active agent.
13. A system comprising:
a receiver; and
a device configured to communicate with the receiver, the device comprising:
a solid support comprising a circuitry element;
a first electrode present on a surface of the solid support and coupled to the circuitry element, wherein the first electrode comprises a first active electrode material present on a porous under-layer, wherein the porous under-layer is selected to provide a surface area enhancement to the first electrode; and
a second electrode present on a surface of the solid support and coupled to the circuitry element, wherein the second electrode is electrically isolated from the first electrode and comprises a second active electrode material that is different from the first active electrode material;
wherein the first and second active electrode materials provide a voltage potential difference to the circuitry element via completion of a battery when the first and second materials contact an electrically conductive fluid within a body; and
wherein the device is configured to communicate a conductively transmitted signal that employs the body as a conduction medium;
wherein upon application of the voltage potential to the circuitry element, the circuitry element is configured to generate the conductively transmitted signal such that the signal is conducted between the circuitry element and the receiver through the body tissues.
14. The system according to claim 13 , wherein said receiver is an in vivo receiver.
15. The system according claim 13 , wherein said receiver is an ex vivo receiver.
16. A method comprising at least one of:
(a) emitting a conductively transmitted signal from an ingestible event marker;
(b) receiving a conductively transmitted signal from an ingestible event marker; and
(c) ingesting an ingestible event marker;
wherein the ingestible event marker comprises:
a solid support comprising a circuitry element;
a first electrode present on a surface of the solid support and coupled to the circuitry element, wherein the first electrode comprises a first active electrode material present on a porous under-layer, wherein the porous under-layer is selected to provide a surface area enhancement to the first electrode;
a second electrode present on a surface of the solid support and coupled to the circuitry element, wherein the second electrode is electrically isolated from the first electrode and comprises a second active electrode material that is different from the first active electrode material;
wherein the first and second active electrode materials provide a voltage potential difference to the circuitry element via completion of a battery when the first and second materials contact an electrically conductive fluid within a body; and
pharmaceutically acceptable carrier composition; and
(d) communicating a conductively transmitted signal that employs the body as a conduction medium;
wherein upon application of the voltage potential to the circuitry element, the circuitry element is configured to generate the conductively transmitted signal such that the signal is conducted between the circuitry element and a receiver through the body tissues.
17. A method comprising:
producing a first electrode on a surface of a solid support of a device by:
providing a porous under-layer on a surface of the solid support, wherein the porous under-layer is selected to provide a surface area enhancement to the first electrode; and
providing a first active electrode material on the porous under-layer; and
producing a second electrode on a surface of the solid support, wherein the second electrode comprises a second active electrode material that is different from the first active electrode material;
wherein the first and second active electrode materials provide a voltage potential difference to a circuitry element via completion of a battery when the first and second materials contact an electrically conductive fluid within a body;
wherein the device is configured to communicate a conductively transmitted signal that employs the body as a conduction medium; and
wherein upon application of the voltage potential to the circuitry element, the circuitry element is configured to generate the conductively transmitted signal such that the signal is conducted between the circuitry element and a receiver through the body tissues.
18. The method according to claim 17 , wherein the porous under-layer is provided by electrodeposition.
19. The method according to claim 17 , wherein the porous under-layer is provided by cathodic arc deposition.
20. The method according to claim 17 , wherein the porous under-layer is provided by electrophoretic deposition.