Granted Patent B2

US 8,876,725 · App. 12/527,697 · Granted Nov 4, 2014

Abstract

Claims (38)

1. A method of estimating exercise capacity of a subject using output radiofrequency signals transmitted to the subject during exercise and input radiofrequency signals received from the subject during exercise, the method comprising:

using a data processor for:

determining a phase shift of the input radiofrequency signals relative to the output radiofrequency signals to provide processed signals;

filtering said processed signals using a dynamically variable filter characterized by a frequency band which is dynamically adapted in response to a change in a physiological condition of the subject;

calculating cardiac output based on said filtered and processed signal; and

using said cardiac output for estimating the exercise capacity of the subject.

2. The method of claim 1 , further comprising obtaining at least one cardiopulmonary exercise testing (CPX) measure pertaining to a cardiopulmonary exercise testing, and combining said cardiac output with said at least one CPX measure to estimate the exercise capacity of the subject.

3. A method of estimating exercise capacity of a subject, comprising:

transmitting output radiofrequency signals to the subject during exercise;

receiving input radiofrequency signals from the subject during exercise; and

executing the method of claim 1 .

4. The method of claim 1 , further comprising reducing or eliminating amplitude modulation of said input radiofrequency signals so as to provide input radiofrequency signals of substantially constant envelope.

5. The method of claim 1 , further comprising mixing said output radiofrequency signals and said input radiofrequency signals so as to provide a mixed radiofrequency signal, and filtering out a portion of said mixed radiofrequency signal so as to substantially increase a signal-to-noise ratio of a remaining portion of said mixed radiofrequency signal.

6. The method of claim 3 , further comprising performing a cardiopulmonary exercise testing to provide at least one CPX measure and combining said cardiac output with said at least one CPX measure to estimate the exercise capacity of the subject.

7. Apparatus for estimating exercise capacity of a subject using output radiofrequency signals transmitted to the subject during exercise and input radiofrequency signals received from the subject during exercise, the apparatus comprising:

a phase shift determinator configured for determining a phase shift of the input radiofrequency signals relative to the output radiofrequency signals, to provide process signals;

a filtering unit configured for filtering said process signals using a dynamically variable filter characterized by a frequency band which is dynamically adapted in response to a change in a physiological condition of the subject;

a cardiac output calculator configured for calculating cardiac output based on said filtered and processed signal; and

an exercise capacity estimator configured for using said cardiac output for estimating the exercise capacity of the subject.

8. The apparatus of claim 7 , wherein said exercise capacity estimator is configured for combining said cardiac output with at least one CPX measure to estimate the exercise capacity of the subject.

9. A system for estimating exercise capacity of a subject, comprising:

a radiofrequency generator for generating output radiofrequency signals;

a plurality of electrodes designed for transmitting said output radiofrequency signals to the subject and for sensing input radiofrequency signals from the subject; and

the apparatus of claim 7 .

10. The system of claim 9 , further comprising a cardiopulmonary exercise testing system configured to provide at least one CPX measure, wherein said exercise capacity estimator is configured for combining said cardiac output with at least one CPX measure to estimate the exercise capacity of the subject.

11. The apparatus of claim 7 , wherein the apparatus further comprises an envelope elimination unit designed and configured for reducing or eliminating amplitude modulation of said input radiofrequency signals so as to provide input radiofrequency signals of substantially constant envelope.

12. The apparatus of claim 7 , wherein the apparatus further comprises:

a mixer configured for mixing said output radiofrequency signals and said input radiofrequency signals, to provide a mixed radiofrequency signal; and

a radiofrequency filter for filtering out a portion of said mixed radiofrequency signal so as to substantially increase a signal-to-noise ratio of a remaining portion of said mixed radiofrequency signal.

13. The method of claim 1 , wherein said cardiac output is calculated using a linear relationship between said phase shift and said cardiac output.

14. The method of claim 1 , wherein said physiological condition is a heart rate of the subject.

15. The method of claim 14 , wherein a lower frequency bound characterizing said filter is about 0.9*(HR/60) Hz at all times, wherein said HR is said heart rate in units of beats per minute.

16. The method of claim 14 , wherein an upper frequency bound characterizing said filter is about 6+1.5*[(HR/60)−1] Hz at all times, wherein said HR is said heart rate in units of beats per minute.

17. The method of claim 2 , wherein said at least one CPX measure comprises ratio of ventilation efficiency to carbon dioxide production rate.

18. The method of claim 2 , wherein said at least one CPX measure comprises oxygen uptake efficiency slope.

19. The Apparatus of claim 7 , wherein said physiological condition is a heart rate of the subject.

20. The Apparatus of claim 19 , wherein a lower frequency bound characterizing said filter is about 0.9*(HR/60) Hz at all times, wherein said HR is a heart rate in units of beats per minute.

21. The Apparatus of claim 19 , wherein an upper frequency bound characterizing said filter is about 6+1.5*[(HR/60)−1] Hz at all times, wherein said HR is said heart rate in units of beats per minute.

Assignments (9)