Medicinal compositions comprising buprenorphine and naltrexone
View Patent ↗An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to or reaching the plasma of a patient is in the range 100:1 to 5000:1. The analgesic action of the buprenorphine is potentiated by the low dose of naltrexone. Also provided are a method of treatment of pain and the use of buprenorphine and naltrexone for the manufacture of a medicament.
1. An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa, the composition comprising buprenorphine and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to, or reaching the plasma of, a patient is in the range 100:1 to 500:1, and wherein the amount of buprenorphine in the unit dosage form is from 10 μg to 1 mg, wherein the composition is an immediate release composition.
2. A composition as claimed in claim 1 , wherein the amount of buprenorphine in the unit dosage form is from 40 μg-1 mg.
3. A composition as claimed in claim 1 , wherein the composition contains buprenorphine and naltrexone in a ratio of 120:1 to 200:1.
4. A composition as claimed in claim 1 , wherein the composition contains buprenorphine and naltrexone in a ratio of 140:1 to 500:1.
5. A composition as claimed in claim 1 , wherein the composition contains buprenorphine and naltrexone in a ratio of 150:1 to 180:1.
6. A method for the treatment of pain in a human patient, which method comprises the administration to a human patient, by a parenteral or mucosal route, of buprenorphine and naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to, or reaching the plasma of, said patient is in the range: 100:1 to 500:1.
7. A method as claimed in claim 6 , wherein the administration of buprenorphine is in the range 0.25 to 640 μg per kg of body weight per 24 hours.
8. A therapeutic method for the treatment of pain comprising the administration by a parenteral or mucosal route of the analgesic composition of claim 1 comprising buprenorphine and naltrexone, wherein the buprenorphine and naltrexone are used in an amount such that the medicament is delivered to a patient, or reaches in the plasma of a patient, at a ratio by weight in the range: 100:1 to 500:1, buprenorphine:naltrexone.
9. A therapeutic method as claimed in claim 8 , wherein the administration of buprenorphine is in the range 0.25 to 640 μg per kg of body weight per 24 hours.