Method for the treatment of amyloidoses
View Patent ↗The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aβ globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.
1. A method for the treatment of an amyloidosis disease comprising administering to a subject in need thereof an agent that inhibits the interaction between Aβ globulomer and P/Q type voltage-gated presynaptic calcium channel, wherein the agent is an antibody that binds to the P/Q type voltage-gated presynaptic calcium channel, wherein the amyloidosis disease is selected from the group consisting of Alzheimer's disease and Down's syndrome, wherein the antibody is raised against a peptide mapping near the C-terminus of the α1A subunit of the P/Q type voltage-gated presynaptic calcium channel, and wherein the antibody is sc-16228.
2. The method of claim 1 , wherein the treatment is for the restoration of memory function.
3. The method of claim 1 , wherein the treatment is for the restoration of performance of activities of daily living (ADL) capacity.