Substituted oxindole compounds

1. A compound of the formula (I)

in which

A is 2-methoxyphenyl, 2-ethoxyphenyl, 2-ethoxy-5-methylphenyl, 2-ethoxy-5-ethylphenyl, 2-ethoxy-5-isopropylphenyl, 2-ethoxy-5-cyclopropylphenyl, 2-chlorophenyl, 2,3-dimethoxyphenyl, 2,4-dimethoxyphenyl, 2-ethoxy-4-fluorophenyl, 2,5-dimethoxyphenyl, 2-ethoxy-3-methoxyphenyl, 2-ethoxy-4-methoxyphenyl, 2-ethoxy-5-methoxyphenyl, 2-ethoxy-5-ethyl-phenyl, 2-isopropyloxy-5-methoxyphenyl, 2-methoxy-5-methylphenyl, 2-isobutyloxy-5-methoxyphenyl, 2-methoxy-5-(dimethylaminomethyl)phenyl, 2-methoxy-5-(methylaminomethyl)phenyl, 2-methoxypyridin-3-yl, 2-ethoxypyridin-3-yl, 2-ethoxy-5-methylpyridin-3-yl, 2-ethoxy-5-ethylpyridin-3-yl, 2-ethoxy-5-isopropylpyridin-3-yl, 2-ethoxy-5-cyclopropylpyridin-3-yl, 2-ethoxy-6-methoxypyridin-3-yl, 2-ethoxy-6-dimethylaminopyridin-3-yl, pyridin-2-yl, 3-methylpyridin-2-yl, 6-chloro-2-methoxypyridin-3-yl, 6-chloro-2-ethoxypyridin-3-yl or 2,6-difluoropyridin-3yl;

B is phenyl, pyridin-2-yl, quinolin-5-yl, quinolin-8-yl, or thienyl, where the aforementioned radicals are unsubstituted or have one, two, three or four substituents

R B where

R B is selected independently of one another from halogen, CN, NO 2 , hydroxy, C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, amino, C 1 -C 4 alkylamino, and di(C 1 -C 4 -alkyl)amino,

R 1 is hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 C 6 -haloalkoxy,

R 2 is hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy,

Y is selected from the groups

in which

* is the linkage to the oxindole unit,

#is the linkage to the Het group,

and

Het is selected from a 2-pyridyl, 3-pyridyl, 4-pyridyl, 4-pyrimidinyl, 2-triazinyl, 1,3-thiazol-2-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl or piperazin-2-yl radical, where the radical is unsubstituted or has one, two or three identical or different substituents R Het which are selected independently of one another from halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyloxy, C 1 -C 6 -haloalkoxy, C 3 -C 7 -cycloalkoxy, di(C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfonyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -alkenyloxy and C 2 -C 6 -alkynyloxy,

where the radical A is different from 2-methoxyphenyl, 2-ethoxyphenyl, 2-ethoxy-5-methylphenyl, 2-ethoxy-5-ethylphenyl, 2-ethoxy-5-isopropylphenyl, 2-ethoxy-5-cyclopropylphenyl, 2-chlorophenyl, 2,3-dimethoxyphenyl, 2,4-dimethoxyphenyl, 2-ethoxy-4-fluorophenyl, 2,5-dimethoxyphenyl, 2-ethoxy-3-methoxyphenyl, 2-ethoxy-4-methoxyphenyl, 2-ethoxy-5-methoxyphenyl, 2-ethoxy-5-ethyl-phenyl, 2-isopropyloxy-5-methoxyphenyl, 2-methoxy-5-methylphenyl 2-isobutyloxy-5-methoxyphenyl 2-methoxy-5-(dimethyl-aminomethyl)phenyl, and 2-methoxy-5-(methylaminomethyl)phenyl when the radical B is phenyl which is unsubstituted or has one, two, three or four substituents R B ,

or a tautomeric, enantiomeric and/or diastereomeric form thereof, or a physiologically tolerated salt or N-oxide of said compound.

2. The compound of the formula (I) according to claim 1 , in which A is 2-methoxy-phenyl, 2-ethoxyphenyl, 2,5-dimethoxyphenyl or 2-ethoxy-5-methoxyphenyl.

3. The compound of the formula (I) as claimed in claim 1 , in which B is pyridin-2-yl or quinolin-8-yl which is unsubstituted or has one, two, three or four substituents R B .

4. The compound of the formula (I) as claimed in claim 3 , in which B is pyridin-2-yl or quinolin-8-yl which is unsubstituted or has a substituent R B in position 5.

5. The compound of the formula (I) as claimed in claim 3 , in which B is pyridin-2-yl, 5-methylpyridin-2-yl, 5-methoxypyridin-2-yl, quinolin-8-yl, 3-methylquinolin-8-yl, 4-methylquinolin-8-yl, 5-methylquinolin-8-yl, 5-methoxyquinolin-8-yl, 4-ethyl-8-quinolinyl, 5-ethoxyquinolin-8-yl, 5-chloroquinolin-8-yl, or 5-fluoroquinolin-8-yl.

6. The compound of the formula (I) as claimed in claim 5 , in which B is 5-methoxy-pyridin-2-yl, quinolin-8-yl or 5-methoxyquinolin-8-yl.

7. The compound of the formula (I) as claimed in claim 1 , in which

B is phenyl and is unsubstituted or has one, two, three or four substituents R B .

8. The compound of the formula (I) as claimed in claim 7 , in which A is 6-chloro-2-ethoxypyridin-3-yl.

9. The compound of the formula (I) as claimed in claim 7 , in which B is 2,3-dimethoxyphenyl, 2,4-dimethoxyphenyl, 3,5-dimethoxyphenyl, 2-ethoxy-4-methoxyphenyl, 4-amino-2-methoxyphenyl, 4-methoxy-2-nitrophenyl, or 2-trifluoromethyl-4-cyanophenyl.

10. The compound of the formula (I) as claimed in claim 9 , in which B is 2,4-dimethoxyphenyl.

11. The compound of the formula (I) as claimed in claim 1 , in which R 1 is CN, chlorine, methyl or methoxy.

12. The compound of the formula (I) as claimed in claim 1 , in which R 2 is hydrogen.

13. The compound of the formula (I) as claimed in claim 1 , in which Y is selected from the groups

14. The compound of the formula (I) as claimed in claim 13 , in which Y is piperazine-1,4-diyl, piperidine-1,4-diyl or homopiperazine-1,4-diyl.

15. The compound of the formula (I) as claimed in claim 1 , in which

Het is selected from pyridin-4-yl, pyridin-3-yl, pyridin-2-yl, 2-methylpyridin-4-yl, 3-methylpyridin-4-yl, 3-ethylpyridin-4-yl, 3-cyclopropylpyridin-4-yl, 2-ethoxypyridin-4-yl, 2-fluoropyridin-4-yl, 2-chloropyridin-4-yl, 2-isopropylpyridin-4-yl, 3-isopropylpyridin-4-yl and 3-fluoropyridin-4-yl.

16. The compound of the formula (I) as claimed in claim 15 , in which Het is pyridin-4-yl which is unsubstituted or has a substituent R Het .

17. The compound of the formula (I) as claimed claim 1 , in which

Het is a piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, piperazin-1-yl or piperazin-2-yl radical which is unsubstituted or has one, two or three identical or different substituents R Het which are selected independently of one another from halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyloxy, C 1 -C 6 -haloalkoxy and C 3 -C 7 -cycloalkyl.

18. The compound of the formula (I) as claimed in claim 1 , in which the group Y-Het is one of the following radicals:

in which * indicates the linkage to the oxindole unit, R Het-1 is hydrogen, methyl or isopropyl, and in which R Het-2 is hydrogen or methyl.

19. A pharmaceutical composition comprising a compound according to claim 1 or pharmaceutically acceptable salt thereof, and a pharmaceutical carrier.

20. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of 5-Chloro-3-(2,4-dimethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(2,3-dimethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one (hydrochloride);

5-Cyano-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-ethoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(2-methyl-4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(3-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Chloro-3-pyridin-2-yl-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one;

5-Chloro-3-(3-methylpyridin-2-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(6-chloro-2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-1-(5-chloroquinoline-8-sulfonyl)-3-(2-ethoxyphenyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(pyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(3-methylpyridin-4-yl)-piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(4-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(3-methyl-4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-1-(4-methylquinoline-8-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(6-chloro-2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diaz abicyclo [2.2.1]hept-2-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-isopropoxy-5-methoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-fluoroquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-3-[4-(2-methylpyridin-4-yl)-piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(2,4-dimethoxybenzenesulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(2,4-dimethoxybenzenesulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(4-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-4-fluorophenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-4-fluorophenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Chloro-3-(2-methoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

3-(2-Methoxyphenyl)-6-methyl-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one;

5-Chloro-3-(2-chlorophenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one;

5-Chloro-3-(5-dimethylaminomethyl-2-methoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-methoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Chloro-3-(2-methoxy-5-methylaminomethylphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxy-4-fluorophenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-1-(5-chloroquinoline-8-sulfonyl)-3-(2-ethoxy-5-methoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-4-fluorophenyl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2,5-dimethoxyphenyl)-1-(4-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-methoxy-5-methylphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-1-(5-chloroquinoline-8-sulfonyl)-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2,6-difluoropyridin-3-yl)-1-(2,4-dimethoxybenzenesulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(2-ethylpyridin-4-yl) piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-isopropylpyridin-4-yl) piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-ethylpyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

3-(2,5-Dimethoxyphenyl)-5-methoxy-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

(+)-5-Cyano-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-2-one;

(+)-5-Cyano-3-(2-ethoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-methylpyridin-4-yl)-[1,4]diazepan-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxyphenyl)-1-(4-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)-[1,4]diazepan-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-[4-(2-cyclopropylpyridin-4-yl) piperazin-1-yl]-3-(2-ethoxy-5-methoxyphenyl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxyphenyl)-1-(5-ethoxyquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(5-pyridin-4-ylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-piperidin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol -2-one hydrochloride;

5-Cyano-3-[4-(2-cyclopropylpyridin-4-yl) piperazin-1-yl]-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-3-yl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-[1,4]diazepan-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2-ethylpyridin-4-yl) piperazin-1-yl]-1-(5-methoxyquinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-[4-(2-methylpyridin-4-yl)-[1,4]diazepan-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(5-pyridin-4-ylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2,3-dihydro-1H-indol -2-one;

(−)5Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-[4-(2-methylpyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]-1-(4-methylquinoline-8-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-yl-[1,4]diazepan-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-fluoroquinoline-8-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(1-methyl-piperidin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(4-ethylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-(4-piperazin-1-ylpiperidin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxyquinoline-8-sulfonyl)-3-(4-piperazin-1-ylpiperidin-1-yl)-2,3-dihydro-1H-indol-2-one hydrochloride;

5-Cyano-3-(2-ethoxyphenyl)-1-(5-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-3-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-[4-(2-cyclopropylpyridin-4-yl)piperazin-1-yl]-3-(2-ethoxy-5-methoxyphenyl)-1-(5-methoxypyridine-2-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-3-[4-(2isopropylpyridin-4-yl) piperazin-1-yl]-1-(5-methoxypyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Chloro-1-(4-methoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-thiazol-2-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-thiazol-2-ylpiperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(4-methoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-[4-(4-cyanopyridin-2-yl)piperazin-1-yl]-1,3-dihydroindol -2-one;

5-Chloro-1-(2-methoxy-4-methylbenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(4-cyanobenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2-methoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-[4-(4-methoxyphenyl)piperazin-1-yl]-3-(2-methoxypyridin-3-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-2-ylpiperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(2-fluorobenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(4-fluorobenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-1-(3,4-dimethoxybenzenesulfonyl)-3-(2-methoxypyridin-3-yl)-3-(4-pyridin-2-ylpiperazin-1-yl)-1,3-dihydroindol -2-one;

5-Chloro-3-(3,4-dimethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(3-dimethylaminomethylphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(2-methoxymethylphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(2-ethoxypyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(2-chloropyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(1-oxidopyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(4-[1,3,5]triazin-2-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(4-pyrimidin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diazabicyclo [2.2.1]hept-2-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Chloro-3-(2-methoxyphenyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(2-methylquinoline-8-sulfonyl)-3-(4-pyridin-4-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(3-fluoropyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(2-fluoropyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-1-(2,5-dimethylthiophene-3-sulfonyl)-3-(2-ethoxyphenyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Cyano-1-(thiophene-2-sulfonyl)-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1,3-dihydroindo1-2-one;

5-Cyano-1-(5-chlorothiophene-2-sulfonyl)-3-(2-ethoxyphenyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Cyano-1-(thiophene-3-sulfonyl)-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1,3-dihydroindol-2-one;

5-Cyano-3-(2-ethoxyphenyl)-1-(8-methoxyquinoline-5-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(6-methylquinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(7-methylquinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(6-chloro-2-methoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(2,4-dimethoxybenzenesulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(4-methylquinoline-8-sulfonyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diazabicyclo[2.2.1]hept-2-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(quinoline-8-sulfonyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diazabicyclo[2.2.1]hept-2-yl)-2,3-dihydro-1H-indol-2-one;

(3R)-5-Cyano-3-(2-ethoxy-5-methoxyphenyl)-1-(quinoline-8-sulfonyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diazabicyclo[2.2.1]hept-2-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2,6-dimethoxypyridin-3-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2,6-dimethoxypyridin-3-yl)-1-(2,4-dimethoxybenzenesulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-4-yl)-1-(5-methylpyridine-2-sulfonyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxypyridin-4-yl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol -2-one;

5-Cyano-3-(2-ethoxyphenyl)-3-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2,5-dimethoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-[4-(2-trifluoromethylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2,5-dimethoxyphenyl)-1-(5-methylpyridine-2-sulfonyl)-3-[4-(2-trifluoromethylpyridin-4-yl)piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperidin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol-2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperazin-1-yl-piperidin-1-yl)-2,3-dihydro-1H-indol-2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-fluoro-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-3-[4-(4-ethyl-piperazin-1-yl)-piperidin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-3-[4-(2-ethyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-fluoro-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-pyridin-4-yl-[1,4]diazepan-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(5-pyridin-4-yl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[5-(2-methyl-pyridin-4-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-phenyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-fluoro-p henyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-3-[4-(2-is opropyl-pyridin-4-yl)-[1,4]diazepan-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-((1S,4S)-5-pyridin-4-yl-2,5-diaza-bicyclo [2.2.1]hept-2-yl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperazin-1-yl-piperidin-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methyl-phenyl)-1-(5-methoxy-quinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-ethyl-phenyl)-1-(5-methoxy-quinoline-8-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-quinoline-8-sulfonyl)-3-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-quinoline-8-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

(+)-5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-ethyl-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-ethyl-phenyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-pyridin-4-yl-[1,4]diazepan-1-yl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-5-methyl-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-pyridin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperidin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one as hydrochloride acid addition;

5-Cyano-3-(2-ethoxy-3-methoxy-phenyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol-2-one;

5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperazin-1-yl-piperidin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-3-[4-(2-isopropyl-pyridin-4-yl)-piperazin-1-yl]-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperidin-4-yl-piperazin-1-yl)-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-[1,4]diazepan-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-4-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-3-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-(2-ethoxy-5-methyl-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-[4-(2-methyl-pyridin-4-yl)-piperazin-1-yl]-2,3-dihydro-1H-indol -2-one;

5-Cyano-3-[4,4′]bipiperidinyl-1-yl-3-(2-ethoxy-5-methoxy-phenyl)-1-(5-methoxy-pyridine-2-sulfonyl)-2,3-dihydro-1H-indol -2-one; and

5-Cyano-3-(6-chloro-2-ethoxy-pyridin-3-yl)-1-(5-methoxy-pyridine-2-sulfonyl)-3-(4-piperazin-1-yl-piperidin-1-yl)-2,3-dihydro-1H-indol -2-one.