Bone cement with adapted mechanical properties
View Patent ↗A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.
1. A bone cement formed from a mixture of a fluid phase and a powder phase, the mixture consisting of:
(i) a powder phase having poly methyl(meth)acrylate or derivatives thereof, an initiator compound, a radiopaque agent, and optionally, hydroxyapatite; and,
(ii) a fluid phase having a reactive monomer, an activator, a stabilizer, and, a substance that is N-methyl-pyrrolidone (NMP), dimethyl-sulfoxide (DMSO), polyethylene glycolide (PEG), cellulose, cellulose derivates, or mixtures thereof;
wherein the substance comprises an amount between 30% and 60% of the fluid phase.
2. The bone cement according to claim 1 , wherein the substance is N-methyl-pyrrolidone.
3. The bone cement according to claim 1 , wherein the substance is dimethyl-sulfoxide (DMSO).
4. The bone cement according to claim 1 , wherein the substance is polyethylene glycolide (PEG).
5. The bone cement according to claim 1 , wherein the substance is cellulose or cellulose derivate.
6. The bone cement according to claim 1 , wherein the substance is a mixture of two or more of N-methyl-pyrrolidone, dimethyl-sulfoxide (DMSO), polyethylene glycolide (PEG), cellulose, or cellulose derivate.
7. The bone cement according to claim 1 , wherein the substance creates a microporous structure in the bone cement.
8. The bone cement according to claim 1 , wherein an elastic modulus of the bone cement is between 50 MPa and 2000 MPa.
9. The bone cement according to claim 1 , wherein an elastic modulus of the bone cement is between 300 MPa and 1500 MPa.
10. The bone cement according to claim 1 , wherein an elastic modulus of the bone cement is between 500 MPa and 1200 MPa.
11. The bone cement according to claim 1 , wherein an elastic modulus of the bone cement is between 100 MPa and 1000 MPa.
12. The bone cement according to claim 1 , wherein a yield strength of the bone cement is between 30 MPa and 100 MPa.
13. The bone cement according to claim 1 , wherein a yield strength of the bone cement is between 40 MPa and 80 MPa.
14. The bone cement according to claim 1 , wherein the bone cement, as hardened, has a Young's modulus that matches osteoporotic bone.
15. The bone cement according to claim 1 , wherein the substance comprises an amount between 30% and 50% of the fluid phase.