Allyloxy and alkyloxy benzoic acid delivery agents

1. A pharmaceutical composition comprising:

(A) a biologically active agent selected from proteins, polypeptides, peptides, hormones, polysaccharides, mucopolysaccharides, carbohydrates, and lipids; and

(B) at least one delivery agent compound selected from

(i) compounds of formula I

and pharmaceutically acceptable salts thereof, wherein

n is 1, 2, 3 or 4;

R1, R2 and R3 are independently hydrogen, methyl or halogen; and

R4 is hydrogen, methyl, methoxy, hydroxy, halogen, acetyl, or 2-hydroxy-ethoxy; and

(ii) compounds of formula III

wherein R is methyl, ethyl, isopropyl, propyl, butyl, allyl, 1-methylallyl, 2-methylallyl, or butenyl.

2. The pharmaceutical composition of claim 1 , wherein at least one of R1-R4 of Formula I is methyl, methoxy, hydroxy, or halogen.

3. The pharmaceutical composition of claim 2 , wherein at least one of R1-R4 of Formula I is chlorine or fluorine.

4. The pharmaceutical composition of claim 1 , wherein at least one of R1-R4 of Formula I is chlorine or fluorine.

5. The pharmaceutical composition of claim 1 , wherein the at least one delivery agent compound is selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

6. The pharmaceutical composition of claim 1 , wherein the biologically active agent is selected from the group consisting of: growth hormones, human growth hormones, recombinant human growth hormones, bovine growth hormones, porcine growth hormones, growth hormone releasing hormones, growth hormone releasing factor, interferons, α-interferon, β-interferon, γ-interferon, interleukin-1, interleukin2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor (IGF), IGF-I, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin, eel calcitonin, porcine calcitonin, human calcitonin, erythropoietin, atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoietin, filgrastim, prostaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine, bisphosphonates, alendronate, tiludronate, etidronate, clodronate, pamidronate, olpadronate, incadronate, parathyroid hormone (PTH), fragments of PTH, anti-migraine agents, sumatriptan, almotriptan, naratriptan, rizatriptan, frovatriptan, eletriptan, BIBN-4096BS, calcitonin gene-related proteins antagonists, glucagon-like peptide 1, Argatroban, glucagon, caspofungin acetate, antimicrobials, antibiotics, anti-bacterials, anti-fungal agents, vitamins, and analogs, mimetics or polyethylene glycol (PEG)-modified derivatives of these compounds, or any combination thereof.

7. The pharmaceutical composition of claim 1 , wherein the biologically active agent is selected from insulin, heparin, human growth hormone, leutinizing-hormone-releasing hormone, and caspofungin acetate.

8. The pharmaceutical composition of claim 7 , wherein the composition comprises about 0.1 to 2.0 mg/kg of insulin and about 50 to 800 mg/kg of the delivery agent compound, or the composition comprises about 5 to 125 mg/kg of heparin and about 5 to 500 mg/kg of the delivery agent compound, or the composition comprises about 0.25 to 10 mg/kg of recombinant human growth hormone and about 50 to 500 mg/kg of the delivery agent compound, or the composition comprises about 0.1 to 10 mg/kg of leutinizing-hormone-releasing hormone and about 50 to 500 mg/kg of the delivery agent compound, or the composition comprises about 5 to 125 mg/kg of caspofungin acetate and about 50 to 500 mg/kg of the delivery agent compound.

9. A method for administering a biologically-active agent to an animal in need of the agent, the method comprising administering orally to the animal the pharmaceutical composition of claim 1 .

10. A method of treating a disease in an animal characterized by hyperglycemia, comprising administering to the animal the pharmaceutical composition of claim 1 .

11. A method of treating a disease in an animal characterized by intravascular thrombi or deep vein thrombosis, comprising administering to the animal the pharmaceutical composition of claim 1 , wherein the biologically active agent is heparin.

12. A method of treating or preventing short stature in a subject, comprising administering to the subject the pharmaceutical composition of claim 1 , wherein the biologically active agent is recombinant human growth hormone.

13. A method of treating a disease that requires supplementation of growth hormone or leutenizing-hormone-releasing hormone, comprising administering to a subject in need thereof the pharmaceutical composition of claim 1 , wherein the biologically active agent is leutenizing-hormone-releasing hormone.

14. A method of treating or preventing infertility in men or women that requires supplementation of leutenizing-hormone-releasing hormone, comprising administering to a subject in need thereof the pharmaceutical composition of claim 1 , wherein the biologically active agent is leutenizing-hormone-releasing hormone.

15. A method of treating candidiasis, comprising administering to a subject in need thereof the pharmaceutical composition of claim 1 , wherein the biologically active agent is caspofungin acetate.

16. A method of increasing the bioavailability of a pharmaceutical composition containing an a biologically an active agent selected from proteins, polypeptides, peptides, hormones, polysaccharides, mucopolysaccharides, carbohydrates, and lipids, comprising adding at least one delivery agent compound of claim 1 to the pharmaceutical composition.

17. A method for preparing a pharmaceutical composition of claim 1 comprising mixing:

(A) at least one biologically active agent selected from proteins, polypeptides, peptides, hormones, polysaccharides, mucopolysaccharides, carbohydrates, and lipids;

(B) at least one said delivery agent; and

(C) optionally, a dosing vehicle.