Oligomer-beta blocker conjugates
View Patent ↗The invention provides water-soluble oligomer-beta blocker drug conjugates. A drug conjugate of the invention can be administered by any of a number of administration routes and exhibits properties that are different from the corresponding beta blocker not attached to the water-soluble oligomer.
1. A compound according to Formula I-C:
wherein:
R 1 is lower alkyl;
R 2 is hydrogen;
R 3 is H or lower alkyl;
R 4 is H or lower alkyl;
R 5 is H or lower alkyl;
R 6 is H or lower alkyl;
R 7 is H or lower alkyl;
Ar is
optionally bears one or more halo, alkyl, alkoxy, or acyl substituents; and
R 19 is H, halo, lower alkyl, lower alkenyl, carbamoyl, cycloalkyl, alkoxy, phenyl, substituted phenyl, amino, or heterocyclyl.
2. The compound of claim 1 , according to Formula Il:
3. The compound of claim 1 , according to Formula Im:
4. A composition comprising a compound of claim 1 , and optionally, a pharmaceutically acceptable excipient.
5. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.
6. The compound of claim 1 according to any of the following structures:
7. The compound of claim 1 according to any of the following structures: