IP Library Granted Patent US 8,916,558
Granted Patent B2
US 8,916,558 · App. 12/530,665 · Granted Dec 23, 2014

Powders for reconstitution

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Quick Facts
Patent No.
US 8,916,558
App. No.
12/530,665
Granted
Dec 23, 2014
Kind
B2
Abstract

This invention relates to powders for reconstitution comprising the NNRTI TMC278 dispersed in certain water-soluble polymers, which can be used in the treatment of HIV infection.

Claims (2)

1. A method of treating an infant, child or elderly patient infected with HIV, said method comprising the oral administration once daily to said infant, child or elderly patient of a supersaturated solution consisting of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]-amino]benzonitrile or a stereoisomeric form thereof, and a water-soluble copolymer of vinylpyrrolidone and vinyl acetate in an aqueous medium wherein in the supersaturated solution the weight: weight ratio of copolymer of vinylpyrrolidone and vinyl acetate to 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]-amino]benzonitrile or a stereoisomeric form thereof is about 9:1.

2. The method according to claim 1 wherein the supersaturated solution consists of (E)- 4[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]-amino]benzonitrile.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2015
From: JANSSEN R & D IRELAND
To: JANSSEN SCIENCES IRELAND UC
Reel/Frame 035496/0382 →
CHANGE OF NAME Recorded Apr 15, 2015
From: TIBOTEC PHARMACEUTICALS
To: JANSSEN R&D IRELAND
Reel/Frame 035439/0981 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2009
From: GYSEGHEM, ELKE VAN; MOOTER, GUY VAN DEN; BAERT, LIEVEN; REMOORTERE, PETER VAN
To: TIBOTEC BVBA
Reel/Frame 023212/0959 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2009
From: K.U. LEUVEN RESEARCH & DEVELOPMENT
To: TIBOTEC PHARMACEUTICALS LTD.
Reel/Frame 023213/0069 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2009
From: TIBOTEC BVBA
To: TIBOTEC PHARMACEUTICALS LTD.
Reel/Frame 023213/0154 →