QUINOLINE DERIVATIVES AS CRTH2 RECEPTOR LIGANDS
Specific quinoline derivatives are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component.
1 . A compound selected from the group consisting of:
[3-(4-cyanobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid,
[3-(4-bromobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid,
[4-ethyl-8-fluoro-3-(4-methanesulfonylbenzyl)-2-methylquinolin-5-yloxy]acetic acid,
[2-ethyl-8-fluoro-3-(4-methanesulfonylbenzyl)-4-methylquinolin-5-yloxy]acetic acid,
[4-difluoromethoxy-2-ethyl-8-fluoro-3-(4-methoxycarbonylaminobenzyl)quinolin-5-yloxy]acetic acid,
[4-difluoromethoxy-2-ethyl-8-fluoro-3-(3-methanesulfonylbenzyl)quinolin-5-yloxy]acetic acid,
(S)-2-[3-(4-chlorobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]propionic acid,
{4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-hydroxy-1-methylethyl)benzyl]quinolin-5-yloxy}acetic acid,
[8-chloro-3-(4-cyanobenzyl)-4-difluoromethoxy-2-ethylquinolin-5-yloxy]acetic acid,
[8-chloro-3-(2-chloro-4-cyanobenzyl)-4-difluoromethoxy-2-ethylquinolin-5-yloxy]acetic acid,
[8-chloro-3-(4-cyanobenzyl)-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid,
[3-(4-cyanobenzyl)-2-difluoromethoxy-8-fluoro-4-methylquinolin-5-yloxy]acetic acid, and salts, N-oxides, hydrates and solvates thereof.
2 . (canceled)
3 . A pharmaceutical composition comprising a compound as claimed in claim 1 and a pharmaceutically acceptable carrier.
4 - 5 . (canceled)
6 . A method of treating a disease selected from asthma, chronic obstructive pulmonary disease, rhinitis, allergic airway syndrome, and allergic rhinobronchitis, comprising administering to a patient suffering such disease an effective amount of a compound as claimed in claim 1 .
7 . The method, according to claim 6 , used for the treatment of psoriasis, atopic and non-atopic dermatitis Crohn's disease, ulcerative colitis, or irritable bowel disease.