Solid fibrinogen preparation
View Patent ↗A fibrinogen preparation is provided which has an improved solubility, may be prepared within a short time and may be used rapidly in clinical set-up. A solid fibrinogen preparation comprising as a main ingredient fibrinogen and further containing the following components: albumin; a nonionic surfactant; a basic amino acid or a salt thereof; and at least two amino acids or a salt thereof selected from an acidic amino acid or a salt thereof and a neutral amino acid or a salt thereof. The solid fibrinogen composition of the present invention may be held on a medical material to form a supporting material holding fibrinogen. Besides, the supporting material holding fibrinogen may be combined with a component comprising as a main ingredient thrombin to provide a fibrin adhesive.
1. A solid fibrinogen composition comprising
fibrinogen, albumin, a non-ionic surfactant and a combination of amino acid or amino acid salts selected from the group consisting of:
isoleucine, glycine, arginine, and glutamic acid, or salts thereof (IGRE);
glycine, arginine, and glutamic acid, or salts thereof (GRE);
isoleucine, glycine, and arginine, or salts thereof (IGR);
leucine, glycine, arginine, and glutamic acid, or salts thereof (LGRE);
isoleucine, alanine, arginine, and glutamic acid, or salts thereof (IARE);
isoleucine, serine, arginine, and glutamic acid, or salts thereof (ISRE);
isoleucine, threonine, arginine, and glutamic acid, or salts thereof (ITRE);
isoleucine, glutamine, arginine, and glutamic acid, or salts thereof (IQRE); and
isoleucine, glycine, lysine and glutamic acid, or salts thereof (IGKE).
2. The solid fibrinogen composition of claim 1 , wherein the surfactant is tyloxapol or polysorbate 80 .
3. The solid fibrinogen composition of claim 1 , further comprising at least one of a monofilament, cotton, paper, cellulose, cellulose derivative, nonwoven fabric, textile, knit, sponge, film or other supporting material.
4. The solid composition of claim 1 , further comprising at least one of collagen, gelatin, polyglycolic acid, polylactic acid, glycolic acid-lactic acid copolymer, polyglutamic acid, or amylose.
5. The solid fibrinogen composition of claim 1 in a lyophilized form and suitable for medical use.
6. A liquid composition produced by contacting water with the solid fibrinogen composition of claim 1 .
7. The liquid composition of claim 6 that rehydrates faster or that has a shorter defoaming time than an otherwise identical composition produced by contacting water with a solid fibrinogen composition that does not contain at least one of albumin, a non-ionic surfactant, or one of the amino acids or amino acid salts in the combination of amino acids or amino acid salts.
8. A solid fibrinogen composition comprising fibrinogen, albumin, a non-ionic surfactant, and a combination of amino acids or amino acid salts selected from the group consisting of:
glycine or a glycine salt, arginine or a salt of arginine, glutamic acid or a salt of glutamic acid (GRE); and
isoleucine or an isoleucine salt, glycine or a glycine salt, arginine or a salt of arginine, (IGR).
9. The solid fibrinogen composition of claim 8 , wherein the surfactant is tyloxapol or polysorbate 80 .
10. The solid fibrinogen composition of claim 8 , further comprising at least one of a monofilament, cotton, paper, cellulose, cellulose derivative, nonwoven fabric, textile, knit, sponge, film or other supporting material.
11. The solid fibrinogen composition of claim 8 , further comprising at least one of collagen, gelatin, polyglycolic acid, polylactic acid, glycolic acid-lactic acid copolymer, polyglutamic acid, or amylose.
12. The solid fibrinogen composition of claim 8 in a lyophilized form and suitable for medical use.
13. A liquid composition produced by contacting water with the solid fibrinogen composition of claim 8 .
14. The liquid composition of claim 13 that rehydrates faster or that has a shorter defoaming time than an otherwise identical composition produced by contacting water with a solid fibrinogen composition that does not contain at least one of albumin, a non-ionic surfactant, or one of the amino acids or amino acid salts in the combination of amino acids or amino acid salts.
15. A solid fibrinogen composition comprising fibrinogen, albumin, a non-ionic surfactant, and isoleucine or an isoleucine salt, glycine or a glycine salt, arginine or a salt of arginine, glutamic acid or a salt of glutamic acid (IGRE).
16. The solid fibrinogen composition of claim 15 , wherein the surfactant is tyloxapol or polysorbate 80 .
17. The solid fibrinogen composition of claim 15 , further comprising at least one of a monofilament, cotton, paper, cellulose, cellulose derivative, nonwoven fabric, textile, knit, sponge, film or other supporting material.
18. The solid fibrinogen composition of claim 15 , further comprising at least one of collagen, gelatin, polyglycolic acid, polylactic acid, glycolic acid-lactic acid copolymer, polyglutamic acid, or amylose.
19. A liquid composition produced by contacting water with the solid fibrinogen composition of claim 15 .
20. The liquid composition of claim 19 that rehydrates faster or that has a shorter defoaming time than an otherwise identical composition produced by contacting water with a solid fibrinogen composition that does not contain at least one of albumin, a non-ionic surfactant, isoleucine or an isoleucine salt, glycine or a glycine salt, arginine or a salt of arginine, or glutamic acid or a salt of glutamic acid.