Method for producing arylhydroxylamine
View Patent ↗The invention provides a method for producing an arylhydroxylamine compound efficiently and safely under mild conditions. The method involves contacting a nitroaryl compound with a hydrogen source in the presence of a platinum catalyst supported on amino group-coordinated silica and a poisoning agent.
1. A method for producing an arylhydroxylamine compound, which comprises contacting a nitroaryl compound with a hydrogen source in the presence of a platinum catalyst supported on amino group-coordinated silica and a poisoning agent.
2. The method according to claim 1 , which is carried out under 0.1 to 1 MPa.
3. The method according to claim 1 , wherein the silica has a specific surface area of 10 m 2 /g to 2000 m 2 /g.
4. The method according to claim 1 , which is carried out at −80 to 100° C.
5. The method according to claim 1 , wherein the hydrogen source is hydrogen gas.
6. The method according to claim 1 , wherein the poisoning agent is a compound comprising an atom having an unshared electron pair selected from an oxygen atom, a phosphorous atom and a sulfur atom.
7. The method according to claim 1 , wherein the amino group is selected from a primary amino group, a secondary amino group, a tertiary amino group and a quaternary ammonium group.
8. The method according to claim 7 , wherein the amino group is a primary amino group.
9. The method according to claim 1 , wherein the platinum catalyst supported on amino group-coordinated silica is obtained by supporting a platinum on silica, which the amino group is introduced.
10. The method according to claim 1 , wherein the platinum catalyst supported on amino group-coordinated silica is obtained by contacting the platinum catalyst supported on silica with an amine compound.
11. The method according to claim 1 , wherein the platinum catalyst supported on amino group-coordinated silica is obtained by supporting an amine compound and a platinum on silica, at the same time.