Granted Patent
B2
US 7,816,393 · App. 12/535,642 · Granted Oct 19, 2010
Isoindoline compounds and methods of their use
Assignee:
Celgene Corporation
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Abstract
Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclosed.
Claims (7)
1. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
R 1 and R 2 , independently of the other, is hydroxyl or NH—Z;
R 3 is hydrogen;
Z is hydrogen or aryl; and
n is 0, 1 or 2.
2. A pharmaceutical composition comprising a compound of claim 1 .
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 4, 2019
From: CELGENE CORPORATION
To: AMGEN INC.
Reel/Frame 051181/0038 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 1, 2011
From: MULLER, GEORGE W.; MAN, HON-WAH
To: CELGENE CORPORATION
Reel/Frame 025878/0257 →
Continuity (2)