Method for the treatment of acne and certain dosage forms thereof

1. An oral dosage form, comprising:

65 mg of minocycline;

a first amount of lactose monohydrate present as an extragranular fast dissolving carrier and a second amount of lactose monohydrate present as an intragranular fast dissolving carrier;

an amount of hydroxypropylmethylcellulose present as an intragranular slow dissolving carrier, wherein the hydroxypropylmethylcellulose is selected from the group consisting of hydroxypropylmethylcellulose that is 8.9%+/−0.2% hydroxypropoxylated and hydroxypropylmethylcellulose that is about 9.1% hydroxypropoxylated, wherein the hydroxypropylmethylcellulose has a viscosity of 40 cps to 60 cps;

wherein the ratio of the extragranular fast dissolving carrier to intragranular slow dissolving carrier is from 0.30 to 0.50;

wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 37% within 1 hour, about 61% within 2 hours, and 90% within 3 hours when the hydroxypropylmethylcellulose is 8.9+/−0.2% hydroxypropoxylated, and

wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 41% within 1 hour, about 68% within 2 hours, about 90% within 3 hours and about 100% within 4 hours when the hydroxypropylmethylcellulose is about 9.1% hydroxypropoxylated.

2. The oral dosage form of claim 1 , further comprising a coating in an amount of 3.5% to 4.0% of the weight of the oral dosage form.

3. An oral dosage form, comprising:

115 mg of minocycline;

a first amount of lactose monohydrate present as an extragranular fast dissolving carrier and a second amount of lactose monohydrate present as an intragranular fast dissolving carrier;

an amount of hydroxypropylmethylcellulose present as an intragranular slow dissolving carrier, wherein the hydroxypropylmethylcellulose is selected from the group consisting of hydroxypropylmethylcellulose that is 8.9%+/−0.2% hydroxypropoxylated and hydroxypropylmethylcellulose that is about 9.1% hydroxypropoxylated, wherein the hydroxypropylmethylcellulose has a viscosity of 40 cps to 60 cps;

wherein the ratio of the extragranular fast dissolving carrier to intragranular slow dissolving carrier is from 0.30 to 0.50;

wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 37% within 1 hour, about 61% within 2 hours, and 90% within 3 hours when the hydroxypropylmethylcellulose is 8.9+/−0.2% hydroxypropoxylated, and

wherein the minocycline has a release rate, as measured in 0.1 N HCl, of about 41% within 1 hour, about 68% within 2 hours, about 90% within 3 hours and about 100% within 4 hours when the hydroxypropylmethylcellulose is about 9.1% hydroxypropoxylated.

4. The oral dosage form of claim 3 , further comprising a coating in an amount of 3.0% to 3.3% of the weight of the oral dosage form.