IP Library Patent Application 12538910
Patent Application
App. No. 12/538,910

FRACTION COLLECTOR DIVERTER VALVE

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Quick Facts
Patent No.
US None
App. No.
12/538,910
Abstract

A diverter valve assembly includes a standard three-way valve and an upstream two-way valve and a further upstream eluant accumulator. When a new container is required for collection, the two-way valve stops the flow from the source. Since the source flow is continuous, the flow is directed into the accumulator pushing a spring loaded piston. When the new container is in position, the two-way valve opens and eluant flow from the source and the accumulator are directed to the new container. There is no flow to waste during the stoppage of flow.

Claims (24)

1 . A diverter apparatus in an eluant flow path to a container, the diverter apparatus comprising:

a two-way valve located in the eluant flow path, the two-way valve having one state where the flow path is blocked and another state where the flow path is open; and

an accumulator accessing the eluant flow path upstream from the two-way vale; wherein when the two-way valve blocks the eluant flow, the eluant flow is directed into the accumulator, and when the two-way valve opens, the eluant flows from the source and from the accumulator to a container.

2 . The diverter valve of claim 1 wherein the accumulator comprises:

a spring loaded piston, wherein the piston is flush with the flow path and presents no added volume to the flow path when the accumulator contains no eluant.

3 . The diverter valve of claim 1 further comprising a three-way valve placed down stream from the two-way valve, the three-way valve having two selected outputs one directed to waste and the other to one of a multi-container array of collection vessels or to a multi-port liquid switching valve to direct flow to a specific collection tubing connection.

4 . The diverter valve of claim 2 wherein the accumulator piston has a center axis that is co-axial with the center axis of the flow path.

5 . A process for diverting an inflowing eluant flow, the process comprising the steps of:

blocking the eluant flow path so that no eluant is flowing to a first container, wherein the eluant is diverted to an accumulator;

accumulating the eluant;

re-placing the first container with a second container.

opening the eluant flow path to the second container; and

delivering eluant flow to the second container partially from the accumulated eluant and partially from the inflowing eluant flow.

6 . The process of claim 5 wherein the accumulating of the eluant comprises the steps of:

driving a piston against a spring, wherein a volume is opened by the moving piston;

diverting the eluant flow into this volume, and

returning the piston to its initial location with a spring, wherein there is no unswept volume in the eluant flow path

7 . The process of claim 5 wherein the accumulator piston has a center axis that is co-axial with a center axis of the flow path.

8 . A process for diverting an eluant flow path to a container, the process comprising the steps of:

stopping the eluant flow to a first container;

replacing the container with a second container;

accumulating the eluant flow, while the flow to the first container is stopped, and, when the second container is in place;

directing flow to the second container; and

releasing volume accumulated during the time the eluant flow is stopped to the first container.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Dec 18, 2025
From: CITIZENS BANK, N.A.
To: HARVARD BIOSCIENCE, INC.; DATA SCIENCES INTERNATIONAL, INC.
Reel/Frame 074022/0661 →
SECURITY INTEREST Recorded Dec 28, 2020
From: HARVARD BIOSCIENCE, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 054855/0481 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 23, 2018
From: BANK OF AMERICA, N.A.
To: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC
Reel/Frame 045127/0745 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 23, 2018
From: BANK OF AMERICA, N.A.
To: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC; TRIANGLE BIOSYSTEMS, INC.
Reel/Frame 045129/0981 →
SECURITY INTEREST Recorded May 16, 2017
From: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC; TRIANGLE BIOSYSTEMS, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 042469/0903 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2013
From: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC
To: BANK OF AMERICA, N.A.
Reel/Frame 030129/0459 →
MERGER Recorded Jun 11, 2012
From: MODULAR SFC, LLC
To: MODULAR SFC, INC.
Reel/Frame 028351/0212 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2012
From: MODULAR SFC, INC.
To: HARVARD BIOSCIENCE, INC.
Reel/Frame 028351/0379 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2009
From: HEDBERG, HERBERT J.
To: MODULAR SFC, LLC
Reel/Frame 023076/0127 →