IP Library Granted Patent US 10,960,168
Granted Patent B2
US 10,960,168 · App. 12/541,148 · Granted Mar 30, 2021

Delivery of high concentration nitric oxide

Inventors: David H. Fine (Cocoa Beach, FL); Lee Leichter (Fort Myers, FL)
Assignee: VERO Biotech LLC
A61M16/12A61K31/04A61M15/008A61P11/00A61M15/0071A61M2202/0208A61M2202/0275A61M2205/8225A61M2205/8231
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Quick Facts
Patent No.
US 10,960,168
App. No.
12/541,148
Granted
Mar 30, 2021
Kind
B2
Abstract

A method and device can alternately deliver high concentration of nitric oxide and oxygen-enriched air. A method of providing a therapeutic amount of nitric oxide to a mammal can include delivering one or more breaths of a therapeutic amount of nitric oxide to the mammal and delivering one or more breaths of an amount of oxygen-enriched air to the mammal immediately after the one or more breaths of the therapeutic amount of nitric oxide.

Claims (18)

1. A method, comprising:

repeatedly delivering, for periods of at least two breaths, between 1000 ppm and 2000 ppm of nitric oxide to a mammal; and

delivering, between each period, at least one breath of oxygen-enriched air to the mammal.

2. The method of claim 1 , further comprising delivering one or more breaths of the oxygen-enriched air to the mammal before delivering the at least two breaths of nitric oxide to the mammal.

3. The method of claim 1 , wherein:

one breath of the oxygen-enriched air is delivered between each period.

4. The method of claim 1 , wherein:

each period of delivery of nitric oxide has a duration of two breaths; and

two breaths of the oxygen-enriched air are delivered between each period.

5. The method of claim 1 , further comprising generating the nitric oxide by exposing nitrogen dioxide to an antioxidant.

6. The method of claim 5 , wherein the antioxidant is at least one of ascorbic acid, alpha tocopherol, or gamma tocopherol.

7. The method of claim 5 , wherein the nitric oxide is delivered to the mammal via a tube that includes the antioxidant.

8. The method of claim 7 , wherein the antioxidant is at least one of ascorbic acid, alpha tocopherol, or gamma tocopherol.

9. The method of claim 1 , wherein the balance of the between 1000 ppm and 2000 ppm of nitric oxide is air.

10. The method of claim 1 , wherein oxygen enriched air contains at least 21% oxygen.

11. The method of claim 1 , wherein:

the nitric oxide is delivered to the mammal via a first tube; and

the oxygen-enriched air is delivered to the mammal via a second tube different from the first tube.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Mar 18, 2026
From: HORIZON TECHNOLOGY FINANCE CORPORATION
To: VERO BIOTECH INC.
Reel/Frame 075308/0198 →
SECURITY INTEREST Recorded Mar 16, 2026
From: VERO BIOTECH INC.
To: SYMBIOTIC CAPITAL AGENCY LLC, AS COLLATERAL AGENT
Reel/Frame 075117/0935 →
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jan 3, 2024
From: RUNWAY GROWTH FINANCE CORP (F/K/A RUNWAY GROWTH CREDIT FUND INC.)
To: VERO BIOTECH INC. (F/K/A VERO BIOTECH LLC)
Reel/Frame 066186/0611 →
SECURITY INTEREST Recorded Jan 3, 2024
From: VERO BIOTECH INC.
To: HORIZON TECHNOLOGY FINANCE CORPORATION
Reel/Frame 066187/0865 →
CHANGE OF NAME Recorded Feb 14, 2022
From: VERO BIOTECH LLC
To: VERO BIOTECH INC.
Reel/Frame 059085/0418 →
SECURITY INTEREST Recorded Dec 29, 2020
From: VERO BIOTECH LLC
To: RUNWAY GROWTH CREDIT FUND INC.
Reel/Frame 054866/0589 →
CHANGE OF NAME Recorded Aug 7, 2018
From: GENO LLC
To: VERO BIOTECH LLC
Reel/Frame 048173/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2010
From: FINE, DAVID H.; LEICHTER, LEE
To: GENO LLC
Reel/Frame 023938/0046 →
Continuity (2)
Provisional Application 61090628 · Aug 21, 2008
Related Publication 20100089392A1 · Apr 15, 2010
Cited By (1)
US 12,544,527