Anti-reflux vial adaptors
View Patent ↗In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.
1. A vial adaptor comprising:
a housing member;
a connector configured to couple the housing member with a vial;
an extractor channel formed in the housing member, the extractor channel configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial;
an anti-reflux valve positioned within the extractor channel, the anti-reflux valve configured to impede or obstruct fluid returning to the vial after withdrawal of at least some of the fluid from the vial;
a sheath extending from the housing member; and
a bag housed at least partially within the sheath, the bag configured to expand in response to pressure changes within the vial as fluid is added to or withdrawn from the vial.
2. The vial adaptor of claim 1 , wherein the sheath is configured to be positioned within the vial when the adaptor is coupled to the vial.
3. The vial adaptor of claim 1 , further comprising a regulator channel formed in the housing member and an expandable vessel operatively connected to the vial adaptor, wherein the regulator channel is configured to provide fluid communication between ambient air and an interior portion of the expandable vessel.
4. The vial adaptor of claim 1 , further comprising a medical connector interface extending from the housing member, the medical connector interface configured to connect the adaptor to a medical connector.
5. The vial adaptor of claim 4 , wherein the medical connector interface defines a proximal portion of the extractor channel, and wherein the anti-reflux valve is positioned within the proximal portion of the extractor channel.
6. The vial adaptor of claim 1 , wherein the anti-reflux valve has a first cracking pressure for fluid flow towards the vial and a second cracking pressure for fluid flow away from the vial.
7. The vial adaptor of claim 6 , wherein the first cracking pressure is greater than the second cracking pressure.
8. The vial adaptor of claim 1 , wherein the anti-reflux valve comprises a component selected from the group consisting of membranes, gaskets, check valves, two-way valves, self-sealing valves, and duckbill valves.
9. The vial adaptor of claim 1 , wherein the anti-reflux valve comprises a dome-shaped valve.
10. The vial adaptor of claim 1 , wherein the anti-reflux valve comprises:
a cup having a base with an opening formed therein; and
a blocking structure disposed adjacent to the base of the cup, the blocking structure configured to obstruct at least a portion of the opening.
11. The vial adaptor of claim 10 , wherein the blocking structure comprises a washer.
12. The vial adaptor of claim 10 , wherein the blocking structure is disposed upstream from the cup when fluid is withdrawn from the vial via the extractor channel.
13. The vial adaptor of claim 1 , wherein a fluid-tight seal exists between the anti-reflux valve and a sidewall of the extractor channel.
14. A method of manufacturing a vial adaptor, the method comprising:
providing a housing member having an extractor channel formed therein, the extractor channel configured to facilitate withdrawal of fluid from a vial when the adaptor is coupled to the vial;
providing a connector configured to couple the housing member with the vial;
positioning an anti-reflux valve within the extractor channel, the anti-reflux valve configured to impede or obstruct fluid returning to the vial after withdrawal of at least some of the fluid from the vial; and
disposing a bag at least partially within a sheath extending from the housing member, wherein the bag is configured to expand in response to pressure changes within the vial as fluid is added to or withdrawn from the vial.
15. The method of claim 14 , wherein the sheath is configured to be positioned within the vial when the adaptor is coupled to the vial.
16. The method of claim 14 , wherein positioning the anti-reflux valve comprises:
positioning a blocking structure within the extractor channel; and
disposing a cup having a base with an opening formed therein within the extractor channel such that the base is adjacent to the blocking structure;
wherein the blocking structure is configured to obstruct at least a portion of the opening.
17. The method of claim 14 , wherein positioning the anti-reflux valve comprises creating a fluid-tight seal between the anti-reflux valve and a sidewall of the extractor channel.