Substituted triazolo-pyridazine derivatives
This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABA-A receptor antagonist and/or a α2, α3 and α5 GABA-A receptor agonist.
1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is CH 3 or CD 3 ;
R 2 is —C(CD) 3 ) 3 ; and
each of Y 1a , Y 1b , and Y 2 is independently hydrogen or deuterium.
2. The compound of claim 1 , wherein Y 1a and Y 1b are the same.
3. The compound of claim 1 , selected from any one of the following compounds:
or a pharmaceutically acceptable salt thereof.
4. The compound of any one of claims 1 , 2 or 3 , wherein any atom not designated as deuterium is present at its natural isotopic abundance.
5. The compound of claim 3 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. A composition comprising a compound of claim 1 and an acceptable carrier.
7. The composition of claim 6 , wherein the composition is formulated for oral administration.
8. The composition of claim 7 formulated for pharmaceutical administration, wherein the carrier is a pharmaceutically acceptable carrier.
9. A method of treating a patient suffering from anxiety or convulsions, comprising the step of administering to a patient in need thereof a composition of claim 8 .